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Results for "

NOMO-1

" in MedChemExpress (MCE) Product Catalog:

13

Inhibitors & Agonists

1

Inhibitory Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-158974
    YTHDC1-IN-1

    		DNA/RNA Synthesis Apoptosis PARP Cancer
    YTHDC1-IN-1 is a selective YTHDC1 inhibitor with a Kd of 49 nM and an IC50 of 0.35 μM. YTHDC1-IN-1 can inhibit the proliferation and induce apoptosis of acute myeloid leukemia cell lines. YTHDC1-IN-1 has anti-tumor activity [1].
    YTHDC1-IN-1
  • HY-16271
    Kevetrin hydrochloride
    4 Publications Verification

    4-Isothioureidobutyronitrile hydrochloride; thioureidobutyronitrile hydrochloride; thioureido butyronitrile hydrochloride

    		 MDM-2/p53 Apoptosis Cancer
    Kevetrin hydrochloride is a potent activator of p53, induces apoptosis in TP53 wild-type and mutant acute myeloid leukemia cells. Kevetrin a preferential cytotoxic activity against blast cells [1] .
    Kevetrin hydrochloride
  • HY-P99272
    Ulocuplumab
    1 Publications Verification

    BMS 936564; MDX 1338; Anti-Human CXCR4 Recombinant Antibody

    		 CXCR Cancer
    Ulocuplumab (Anti-Human CXCR4 Recombinant Antibody/BMS-936564/MDX1338) is a fully human IgG4 anti-CXCR4 antibody. Ulocuplumab induces apoptosis and inhibits CXCL12 mediated CXCR4 activation-migration of chronic lymphocytic leukemia (CLL). Ulocuplumab exhibits antitumor activity in established tumors including acute myeloid leukemia (AML), non-Hodgkin lymphoma (NHL), and multiple myeloma xenograft models [1] .
    Ulocuplumab
  • HY-13495
    ML281
    2 Publications Verification

    		 STK33 PKA Aurora Kinase Bcl-2 Family Apoptosis Metabolic Disease Cancer
    ML281 is a highly selective inhibitor of serine/threonine kinase 33 (STK33) with an IC50 value of 14 nM. ML281 shows 700-fold selectivity over PKA and 550-fold over AurB. ML281 exerts core mechanism by inhibiting STK33: in small cell lung cancer, ML281 downregulates RPS6/BAD signaling phosphorylation, induces apoptosis, and suppresses proliferation, invasion [1]. ML281 reduces STK33-mediated 4-hydroxyphenylpyruvate dioxygenase (HPD) phosphorylation in tyrosinemia . ML281 is suitable for research on STK33 function, KRAS mutation-related cancers (pancreatic cancer, colon cancer, lung adenocarcinoma, etc.), small cell lung cancer, and tyrosinemia-related damage [1]
    ML281
  • HY-172158
    ALKBH5-IN-5
    1 Publications Verification

    		 Anaplastic lymphoma kinase (ALK) Caspase Cancer
    ALKBH5-IN-5 is a highly selective ALKBH5 (IC50 = 0.62 μM, Kd = 804 nM). ALKBH5-IN-5 disrupts ALKBH5 binding to m 6A-RNA and 6mA-DNA substrates. ALKBH5-IN-5 promotes differentiation, induces apoptosis, cause G2-M phase arrest and exerts strong antiproliferative effects in cancer cells. ALKBH5-IN-5 reduces TACC3 and MYC protein levels and increases cleaved caspase-3 levels. ALKBH5-IN-5 exerts antitumor activity in tumor xenograft mice models. ALKBH5-IN-5 can be used for the research of acute myeloid leukemia [1].
    ALKBH5-IN-5
  • HY-13498
    BRD-8899

    		STK33 Cancer
    BRD-8899 is a STK33 inhibitor, with an IC50 of 11 nM [1].
    BRD-8899
  • HY-RS21665
    Nomo1 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Nomo1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nomo1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Nomo1 Mouse Pre-designed siRNA Set A
    Nomo1 Mouse Pre-designed siRNA Set A
  • HY-RS09422
    NOMO1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    NOMO1 Human Pre-designed siRNA Set A contains three designed siRNAs for NOMO1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    NOMO1 Human Pre-designed siRNA Set A
    NOMO1 Human Pre-designed siRNA Set A
  • HY-179267
    FTO-IN-16

    		Fat Mass and Obesity-associated Protein (FTO) c-Myc RAR/RXR Apoptosis Cancer
    FTO-IN-16 (Compound 8a-1), a FTO-IN-15 (HY-179266) prodrug, is a potent FTO inhibitor. FTO-IN-16 suppresses acute myeloid leukemia (AML) cell viability, increases m 6A levels, downregulates c-Myc and CEBPA, and upregulates ASB2 and RARA. FTO-IN-16 induces apoptosis. FTO-IN-16 demonstrates strong in vivo efficacy in AML mouse xenografts. FTO-IN-16 can be used for the research of AML [1].
    FTO-IN-16
  • HY-163678
    Pomalidomide-CO-C7-NH-CO-C3-COOH

    		E3 Ligase Ligand-Linker Conjugates Cancer
    Pomalidomide-CO-C7-NH-CO-C3-COOH is a conjugate of a ligand for E3 ligase and a linker. Pomalidomide-CO-C7-NH-CO-C3-COOH can be used for synthesis of PROTAC degrader ARM165 (HY-163677) [1].
    Pomalidomide-CO-C7-NH-CO-C3-COOH
  • HY-RS28183
    Nomo1 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others
    Nomo1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nomo1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Nomo1 Rat Pre-designed siRNA Set A
    Nomo1 Rat Pre-designed siRNA Set A
  • HY-186013
    CML-07-119

    		Apoptosis Cancer
    CML-07-119 is a selective inhibitor of GGPP synthase (GGPPS) with an IC50 of ~27 nM. CML-07-119 induces apoptosis and exhibits anticancer activity against acute myeloid leukemia (AML) cells, including those harbouring TP53 mutations. CML-07-119 inhibits tumor growth in an AML mouse xenograft model. CML-07-119 can be used for AML research [1].
    CML-07-119
  • HY-182681
    AV-9606-129

    		Deubiquitinase c-Myc Cancer
    AV-9606-129 is a USP28 inhibitor with an IC50 of < 1 μM. AV-9606-129 inhibits the enzymatic activity of USP28 and downregulates the protein levels of c-Myc and c-Myb. AV-9606-129 can be used in cancer research [1].
    AV-9606-129

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