2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Pomalidomide-CO-C7-NH-CO-C3-COOH

Pomalidomide-CO-C7-NH-CO-C3-COOH is a conjugate of a ligand for E3 ligase and a linker. Pomalidomide-CO-C7-NH-CO-C3-COOH can be used for synthesis of PROTAC degrader ARM165 (HY-163677).

For research use only. We do not sell to patients.

Pomalidomide-CO-C7-NH-CO-C3-COOH

Pomalidomide-CO-C7-NH-CO-C3-COOH Chemical Structure

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Based on 1 publication(s) in Google Scholar

Pomalidomide-CO-C7-NH-CO-C3-COOH Related Antibodies

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Description

Pomalidomide-CO-C7-NH-CO-C3-COOH is a conjugate of a ligand for E3 ligase and a linker. Pomalidomide-CO-C7-NH-CO-C3-COOH can be used for synthesis of PROTAC degrader ARM165 (HY-163677)[1].

Molecular Weight

528.55

Formula

C26H32N4O8
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CCCC(NCCCCCCCC(NC1=CC=CC2=C1C(N(C2=O)C3CCC(NC3=O)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 4.17 mg/mL (7.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8920 mL 9.4598 mL 18.9197 mL
5 mM 0.3784 mL 1.8920 mL 3.7839 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8920 mL 9.4598 mL 18.9197 mL 47.2992 mL
5 mM 0.3784 mL 1.8920 mL 3.7839 mL 9.4598 mL
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Pomalidomide-CO-C7-NH-CO-C3-COOH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pomalidomide-CO-C7-NH-CO-C3-COOHE3 Ligase Ligand-Linker ConjugatesAMLacute myeloid leukemiavenetoclaxantileukemiaU937KG1αHL60OCI-AML3OCI-AML2MOLM-14MV4-11MCF7HCT116HT29NOMO-1Inhibitorinhibitorinhibit

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Pomalidomide-CO-C7-NH-CO-C3-COOH
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