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Cat. No.: HY-182681

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AV-9606-129

AV-9606-129 is a USP28 inhibitor with an IC₅₀ of < 1 μM. AV-9606-129 inhibits the enzymatic activity of USP28 and downregulates the protein levels of c-Myc and c-Myb. AV-9606-129 can be used in cancer research.

For research use only. We do not sell to patients.

CAS No.: 783309-48-8
Formula: C₁₇H₁₈Cl₂N₂O₃S
Molecular Weight:401.31

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

AV-9606-129 Chemical Structure

CAS No.: 783309-48-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Bioz

Biological Activity

Description

All Deubiquitinase Isoforms :

In Vitro

AV-9606-129 (30 min; 30 min) potently inhibits purified recombinant USP28 protein with an IC₅₀ of < 1 μM^[1].
AV-9606-129 (100 μM) modulates the activity of a subset of 41 tested purified deubiquitinase enzymes^[1].
AV-9606-129 (1 h) dose-dependently engages endogenous USP28 in K562 cell lysates, as demonstrated by reduced Ub-VME labeling of USP28^[1].
AV-9606-129 (25-100 μM) downregulates C-Myc and C-Myb protein levels in NOMO-1, K562, MOLM14, and MM1S human cancer cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 783309-48-8
Molecular Weight 401.31
Formula C₁₇H₁₈Cl₂N₂O₃S
SMILES

O=C(CC1=CC=C(C(Cl)=C1)Cl)NC2=CC(S(=O)(N(C)C)=O)=CC=C2C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Buhrlage S. Substituted 3-amino-4-methylbenzenesulfonamides as small molecule inhibitors of ubiquitin-specific protease 28, WO, WO2022035804A1, 2022-02-17.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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