2. Cell Cycle/DNA Damage Apoptosis
  3. Deubiquitinase c-Myc
  4. AV-9606-129

AV-9606-129 is a USP28 inhibitor with an IC50 of < 1 μM. AV-9606-129 inhibits the enzymatic activity of USP28 and downregulates the protein levels of c-Myc and c-Myb. AV-9606-129 can be used in cancer research.

For research use only. We do not sell to patients.

AV-9606-129

AV-9606-129 Chemical Structure

CAS No. : 783309-48-8

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AV-9606-129 Related Antibodies

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USP1 USP2 USP4 USP7 USP8 USP10 USP21 USP30 UCHL1 USP11 USP15

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Description

AV-9606-129 is a USP28 inhibitor with an IC50 of < 1 μM. AV-9606-129 inhibits the enzymatic activity of USP28 and downregulates the protein levels of c-Myc and c-Myb. AV-9606-129 can be used in cancer research[1].

In Vitro

AV-9606-129 (30 min; 30 min) potently inhibits purified recombinant USP28 protein with an IC50 of < 1 μM[1].
AV-9606-129 (100 μM) modulates the activity of a subset of 41 tested purified deubiquitinase enzymes[1].
AV-9606-129 (1 h) dose-dependently engages endogenous USP28 in K562 cell lysates, as demonstrated by reduced Ub-VME labeling of USP28[1].
AV-9606-129 (25-100 μM) downregulates C-Myc and C-Myb protein levels in NOMO-1, K562, MOLM14, and MM1S human cancer cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AV-9606-129 Related Antibodies
Molecular Weight

401.31

Formula

C17H18Cl2N2O3S
CAS No.
SMILES

O=C(CC1=CC=C(C(Cl)=C1)Cl)NC2=CC(S(=O)(N(C)C)=O)=CC=C2C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AV-9606-129 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AV-9606-129783309-48-8Deubiquitinasec-MycDUBsMycUb-VMEUSP28NOMO-1C-MycUbiquitin-specific protease 28cancerK562 cell lysatesdeubiquitinase enzymesMM1SC-MybInhibitorinhibitorinhibit

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