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Results for "

PYR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Amino Acid Derivatives (1) Amyloid-β (2) Antibiotic (1) Apelin Receptor (APJ) (2) Apoptosis (1) Autophagy (1) Biochemical Assay Reagents (2) c-Myc (1) Cholecystokinin Receptor (1) Dihydrofolate reductase (DHFR) (1) E1/E2/E3 Enzyme (1) Fluorescent Dye (1) GnRH Receptor (3) HIV (1) nAChR (1) Neurokinin Receptor (1) Parasite (1) TRP Channel (3)
By Research Areas:	Cancer (3) Cardiovascular Disease (2) Endocrinology (1) Infection (2) Neurological Disease (6)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13296

PYR-41 Maximum Cited Publications 11 Publications Verification	E1/E2/E3 Enzyme Apoptosis	Cancer
PYR-41 is a selective and cell permeable inhibitor of ubiquitin-activating enzyme E1 with an IC₅₀ of < 10 μM, with little activity at E2 and E3.

HY-153225

PYR01	HIV	Infection
PYR01 is a potent HIV-1 nonnucleoside reverse transcriptase inhibitor. PYR01 is an also targeted activator of cell kill molecules eliminate cells expressing HIV-1 .

HY-W010929

PYR14-TFSI	Biochemical Assay Reagents	Others
PYR14-TFSI is a room temperature ionic liquid (RTIL) with a wide electrochemical window (5.5V) and a high viscosity, making it a useful candidate for electrochemical energy applications .

HY-19408

Pyr10 3 Publications Verification	TRP Channel	Others
Pyr10 is a pyrazole derivative and a selective TRP cation 3 (TRPC3) inhibitor. Pyr10 inhibits Ca ²⁺ influx in carbachol-stimulated TRPC3-transfected HEK293 cells with an IC₅₀ of 0.72 μM (IC₅₀ of 13.08 μM for store operated Ca ²⁺ entry in BRL-2H3 cells). Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels .

HY-W009472

L-Pyroglutamic acid β-naphthylamide

PYR
Fluorescent Dye Amino Acid Derivatives Others

L-Pyroglutamic acid β-naphthylamide (PYR) is aglutamic acid derivatives.
HY-P2000

Septide

(PYR6,Pro9)-Substance P
Neurokinin Receptor Neurological Disease

Septide ((Pyr6,Pro9)-Substance P) is a potent NK1 receptor agonist with a K_d value of 0.55 nM .

L-Pyroglutamic acid β-naphthylamide PYR	Fluorescent Dye Amino Acid Derivatives	Others
L-Pyroglutamic acid β-naphthylamide (PYR) is aglutamic acid derivatives.

Septide (PYR6,Pro9)-Substance P	Neurokinin Receptor	Neurological Disease
Septide ((Pyr6,Pro9)-Substance P) is a potent NK1 receptor agonist with a K_d value of 0.55 nM .

HY-P4882

*(Pyr3)-Amyloid β-Protein (3-42)*	Amyloid-β	Neurological Disease
(Pyr3)-Amyloid β-Protein (3-42) is the predominant amyloid β-peptide structure deposited in human brain of Alzheimer's disease and Down's syndrome patients. (Pyr3)-Amyloid β-Protein (3-42) is suggested to accumulate in the brain and to trigger the formation of insoluble amyloid β-peptide deposits .

HY-108465

Pyr3 5+ Cited Publications	TRP Channel	Others
Pyr3 is a selective inhibitor of transient receptor potential canonical channel 3 (TRPC3), with an IC₅₀ of 700 nM for TRPC3-mediated Ca ²⁺ influx.

HY-P4882A

*(Pyr3)-Amyloid β-Protein (3-42) (TFA)*	Amyloid-β	Neurological Disease
(Pyr3)-Amyloid β-Protein (3-42) TFA is the predominant amyloid β-peptide structure deposited in human brain of Alzheimer's disease and Down's syndrome patients. (Pyr3)-Amyloid β-Protein (3-42) TFA is suggested to accumulate in the brain and to trigger the formation of insoluble amyloid β-peptide deposits .

HY-12504

Pyr6 1 Publications Verification N-[4-[3,5-Bis(trifluoromethyl)-1H-PYRazol-1-yl]phenyl]-3-fluoro-4-PYRidinecarboxamide	TRP Channel	Others
Pyr6 is a selective inhibitor of TRPC3 with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells).

HY-118115

Pyrabactin	Others	Others
Pyrabactin is a seed-selective abscisic acid (ABA) agonist that acts through Pyrabactin Resistance 1 (PYR1). Pyrabactin is used as a synthetic plant growth inhibitor .

HY-107680

*3-Pyr-Cytisine* 3-PYR-Cyt	nAChR	Neurological Disease
3-Pyr-Cytisine (3-Pyr-Cyt) is a cytisine derivative. 3-Pyr-Cytisine is a very weak α4β2 nAChR partial agonist that has been studied as an antidepressant .

HY-19735

KJ Pyr 9

5 Publications Verification

c-Myc Autophagy Cancer

KJ Pyr 9 is an inhibitor of MYC with a K_d of 6.5 nM in in vitro assay.

*KJ Pyr* 9** 5 Publications Verification	c-Myc Autophagy	Cancer
KJ Pyr 9 is an inhibitor of MYC with a K_d of 6.5 nM in in vitro assay.

HY-P1033

*[Pyr1]-Apelin-13* 1 Publications Verification [pGlu1]-Apelin-13	Apelin Receptor (APJ)	Cardiovascular Disease
[Pyr1]-Apelin-13 is a highly potent, selective endogenous apelin receptor (APJ) agonist.

HY-W009673

*Boc-Pyr-OH* N-Boc-L-PYRoglutamic acid	Biochemical Assay Reagents	Others
Boc-Pyr-OH is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P4463

*(Des-Pyr1)-LHRH*	GnRH Receptor	Others
(Des-Pyr1)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P4467

*(Des-Pyr1,Des-Gly10,D-Leu6,Pro-NHEt9)-LHRH* (Des-PYR1)-Leuprolide	GnRH Receptor	Others
(Des-Pyr1,Des-Gly10,D-Leu6,Pro-NHEt9)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P4447

*(Des-Gly10,D-Pyr1,D-Leu6,Pro-NHEt9)-LHRH*	GnRH Receptor	Others
(Des-Gly10,D-Pyr1,D-Leu6,Pro-NHEt9)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P2416

Gastrin I, rat

Rat Gastrin-17
Cholecystokinin Receptor Endocrinology

Gastrin I, rat (Rat Gastrin-17) is a peptide hormone, can stimulate gastric acid secretion potently .

Gastrin I, rat Rat Gastrin-17	Cholecystokinin Receptor	Endocrinology
Gastrin I, rat (Rat Gastrin-17) is a peptide hormone, can stimulate gastric acid secretion potently .

HY-161063

DHFR-IN-14	Dihydrofolate reductase (DHFR)	Cancer
DHFR-IN-14 (compound 32) is a pyrimethamine (Pyr)-type, dihydrofolate reductase (DHFR) inhibitor with potential anticancer activity .

HY-139485

BMS-986224	Apelin Receptor (APJ)	Cardiovascular Disease
BMS-986224 is a potent, selective and orally active APJ receptor agonist (K_d = 0.3 nM). BMS-986224 exhibits similar receptor binding and signaling profile to (Pyr ¹) apelin-13. BMS-986224 has the potential for the research of heart failure .

HY-B0439S1

Sulfadoxine D3 Sulphadoxine d₃	Parasite Antibiotic	Infection
Sulfadoxine-d₃ is a deuterium labeled Sulfadoxine (HY-B0439). Sulfadoxine is a sulfonamide that is used, usually in combination with Pyrimethamine (HY-18062), for multidrug-resistant Plasmodium falciparum and P. vivax inhibition. Unlike PYR, Sulfadoxine has no impact on HIV replication or MT-2 cell cycle progression. But also Sulfadoxine exhibits suppression on respiratory, and urinary tract infections[1][2][3][4].

PYR14-TFSI	Biochemical Assay Reagents
PYR14-TFSI is a room temperature ionic liquid (RTIL) with a wide electrochemical window (5.5V) and a high viscosity, making it a useful candidate for electrochemical energy applications .

*Boc-Pyr-OH* N-Boc-L-PYRoglutamic acid	Biochemical Assay Reagents
Boc-Pyr-OH is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Cat. No.	Product Name	Target	Research Area

HY-P2000

Septide

(PYR6,Pro9)-Substance P
Neurokinin Receptor Neurological Disease

Septide ((Pyr6,Pro9)-Substance P) is a potent NK1 receptor agonist with a K_d value of 0.55 nM .
HY-W009472

L-Pyroglutamic acid β-naphthylamide

PYR
Fluorescent Dye Amino Acid Derivatives Others

L-Pyroglutamic acid β-naphthylamide (PYR) is aglutamic acid derivatives.
HY-P4859

Pyr-Gly

Peptides Others

Pyr-Gly is an inhibitory peptide. Pyr-Gly inhibits proliferation of retinal pigment epithelium (RPE) cells and fibroblasts .

Septide (PYR6,Pro9)-Substance P	Neurokinin Receptor	Neurological Disease
Septide ((Pyr6,Pro9)-Substance P) is a potent NK1 receptor agonist with a K_d value of 0.55 nM .

L-Pyroglutamic acid β-naphthylamide PYR	Fluorescent Dye Amino Acid Derivatives	Others
L-Pyroglutamic acid β-naphthylamide (PYR) is aglutamic acid derivatives.

Pyr-Gly	Peptides	Others
Pyr-Gly is an inhibitory peptide. Pyr-Gly inhibits proliferation of retinal pigment epithelium (RPE) cells and fibroblasts .

HY-P4888

*(Pyr11)-Amyloid β-Protein (11-40)*	Peptides	Neurological Disease
(Pyr11)-Amyloid β-Protein (11-40) (A beta 11pE-40) is a peptide. (Pyr11)-Amyloid β-Protein (11-40) can be used for the research of Alzheimer's disease .

HY-P4579

Pyr-Phe-OH	Peptides	Others
Pyr-Phe-OH is an effective pyrene-based hydrogel. Pyr Phe OH can self-assemble into hydrogels in the range of pH=7.5-14.0, and also shows a very low gel concentration (0.037% (w/v)) in phosphate buffer .

HY-P4882

*(Pyr3)-Amyloid β-Protein (3-42)*	Amyloid-β	Neurological Disease
(Pyr3)-Amyloid β-Protein (3-42) is the predominant amyloid β-peptide structure deposited in human brain of Alzheimer's disease and Down's syndrome patients. (Pyr3)-Amyloid β-Protein (3-42) is suggested to accumulate in the brain and to trigger the formation of insoluble amyloid β-peptide deposits .

HY-P4882A

*(Pyr3)-Amyloid β-Protein (3-42) (TFA)*	Amyloid-β	Neurological Disease
(Pyr3)-Amyloid β-Protein (3-42) TFA is the predominant amyloid β-peptide structure deposited in human brain of Alzheimer's disease and Down's syndrome patients. (Pyr3)-Amyloid β-Protein (3-42) TFA is suggested to accumulate in the brain and to trigger the formation of insoluble amyloid β-peptide deposits .

HY-P4349

Pyr-Arg-Thr-Lys-Arg-AMC	Peptides	Others
Pyr-Arg-Thr-Lys-Arg-AMC is a AMC peptide. AMC is a decapeptide that is specifically hydrolyzed by proteases such as trypsin and thrombin. The AMC peptide can be used to determine the activity of protease and the potency of enzyme inhibitors .

HY-P4349A

Pyr-Arg-Thr-Lys-Arg-AMC TFA	Peptides	Others
Pyr-Arg-Thr-Lys-Arg-AMC TFA is a AMC peptide. AMC is a decapeptide that is specifically hydrolyzed by proteases such as trypsin and thrombin. The AMC peptide can be used to determine the activity of protease and the potency of enzyme inhibitors .

HY-P1033

*[Pyr1]-Apelin-13* 1 Publications Verification [pGlu1]-Apelin-13	Apelin Receptor (APJ)	Cardiovascular Disease
[Pyr1]-Apelin-13 is a highly potent, selective endogenous apelin receptor (APJ) agonist.

HY-P4463

*(Des-Pyr1)-LHRH*	GnRH Receptor	Others
(Des-Pyr1)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P4467

*(Des-Pyr1,Des-Gly10,D-Leu6,Pro-NHEt9)-LHRH* (Des-PYR1)-Leuprolide	GnRH Receptor	Others
(Des-Pyr1,Des-Gly10,D-Leu6,Pro-NHEt9)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P4886

Amyloid β-Protein (3-42)	Peptides	Neurological Disease
Amyloid β-Protein (3-42) is the precursor of Pyr peptide. Pyroglutamate-modified Aβ (pEAβ) (3-42) is the core of the amyloid template block in Alzheimer's disease. pEAβ(3-42) accelerated the aggregation of Aβ(1-42), while Aβ(1-42) significantly slowed the primary and secondary nucleation of pEAβ(3-42) .

HY-P4447

*(Des-Gly10,D-Pyr1,D-Leu6,Pro-NHEt9)-LHRH*	GnRH Receptor	Others
(Des-Gly10,D-Pyr1,D-Leu6,Pro-NHEt9)-LHRH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P2416

Gastrin I, rat

Rat Gastrin-17
Cholecystokinin Receptor Endocrinology

Gastrin I, rat (Rat Gastrin-17) is a peptide hormone, can stimulate gastric acid secretion potently .

Gastrin I, rat Rat Gastrin-17	Cholecystokinin Receptor	Endocrinology
Gastrin I, rat (Rat Gastrin-17) is a peptide hormone, can stimulate gastric acid secretion potently .

HY-P4791

Orexin A (1-15) (free acid)	Peptides	Others
Orexin A (1-15) (free acid) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P4398

(Cys(Acm)6,12)-Orexin A (human, mouse, rat)	Peptides	Others
(Cys(Acm)6,12)-Orexin A (human, mouse, rat) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

Sulfadoxine D3
Sulfadoxine-d₃ is a deuterium labeled Sulfadoxine (HY-B0439). Sulfadoxine is a sulfonamide that is used, usually in combination with Pyrimethamine (HY-18062), for multidrug-resistant Plasmodium falciparum and P. vivax inhibition. Unlike PYR, Sulfadoxine has no impact on HIV replication or MT-2 cell cycle progression. But also Sulfadoxine exhibits suppression on respiratory, and urinary tract infections[1][2][3][4].

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