Sulfadoxine-d₃  (Synonyms: Sulphadoxine d₃)

Sulfadoxine-d₃ is a deuterium labeled Sulfadoxine (HY-B0439). Sulfadoxine is a sulfonamide that is used, usually in combination with Pyrimethamine (HY-18062), for multidrug-resistant Plasmodium falciparum and P. vivax inhibition. Unlike PYR, Sulfadoxine has no impact on HIV replication or MT-2 cell cycle progression. But also Sulfadoxine exhibits suppression on respiratory, and urinary tract infections[1][2][3][4].

Sulfadoxine (0-100 μM; 7 d) has no impact on HIV-1 replication in MT-2 cells^[4].
Sulfadoxine (100 μM; 48 h) has no impact on induction of S-phase accumulation in MT-2 cells^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sulfadoxine (0.1, 0.3, 10 mg/kg/d; p.o.; once daily for 3 d) in combination with azithromycin (30 mg/kg/d; p.o.; once daily for 3 d) shows efficacy against blood stage parasites or Plasmodium yoelii sporozoite in a mouse malaria model^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

313.35

C₁₂H₁₁D₃N₄O₄S

1262770-70-6

Solid

White to off-white

O=S(C1=CC=C(N)C=C1)(NC2=NC=NC(OC([2H])([2H])[2H])=C2OC)=O

Room temperature in continental US; may vary elsewhere.

• [1]. Ratcliff A, et al. Therapeutic response of multidrug-resistant Plasmodium falciparum and P. vivax to chloroquine and sulfadoxine-pyrimethamine in southern Papua, Indonesia. Trans R Soc Trop Med Hyg. 2007 Apr;101(4):351-9.  [Content Brief]

  [2]. Fey K, et al. Empfindlichkeit bakterieller Krankheitserreger aus dem Respirationstrakt von Pferden gegenüber Trimethoprim, Sulfadoxin, Sulfadimethoxin und Kombinationen dieser Wirkstoffe [Susceptibility of bacterial isolates from the equine respiratory tract to trimethoprim, sulfadoxine, sulfadimethoxine and combinations of these compounds]. Tierarztl Prax. 1995 Apr;23(2):148-54. German.  [Content Brief]

  [3]. Baraff LJ. Emergency medicine-important advances in clinical medicine: single-dose treatment of urinary tract infections. West J Med. 1983 Jan;138(1):89-90.  [Content Brief]

  [4]. Oguariri RM, et al. Evaluation of the effect of pyrimethamine, an anti-malarial drug, on HIV-1 replication. Virus Res. 2010 Nov;153(2):269-76.  [Content Brief]

  [5]. Neerja J, et al. Plasmodium yoelii: activity of azithromycin in combination with pyrimethamine or sulfadoxine against blood and sporozoite induced infections in Swiss mice. Exp Parasitol. 2004 Jul-Aug;107(3-4):120-4.  [Content Brief]