Sulfadoxine-d3
Based on 1 Customer Validation
Sulfadoxine-d3 is a deuterium labeled Sulfadoxine (HY-B0439). Sulfadoxine is a sulfonamide that is used, usually in combination with Pyrimethamine(HY-18062), for multidrug-resistant Plasmodium falciparum and P. vivax inhibition. Unlike PYR, Sulfadoxine has no impact on HIV replication or MT-2 cell cycle progression. But also Sulfadoxine exhibits suppression on respiratory, and urinary tract infections.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 1262770-70-6
- Formula: C12H11D3N4O4S
- Molecular Weight:313.35
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Plasmodium |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1262770-70-6
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Unlabeled Cas 2447-57-6
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Appearance Solid
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Molecular Weight 313.35
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Formula C12H11D3N4O4S
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Color White to off-white
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SMILES
O=S(C1=CC=C(N)C=C1)(NC2=NC=NC(OC([2H])([2H])[2H])=C2OC)=O
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Synonyms
Sulphadoxine d3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 100 mg/mL (319.13 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 0.1 mg/mL (0.32 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Ratcliff A, et al. Therapeutic response of multidrug-resistant Plasmodium falciparum and P. vivax to chloroquine and sulfadoxine-pyrimethamine in southern Papua, Indonesia. Trans R Soc Trop Med Hyg. 2007 Apr;101(4):351-9. [Content Brief]
[2]. Fey K, et al. Empfindlichkeit bakterieller Krankheitserreger aus dem Respirationstrakt von Pferden gegenüber Trimethoprim, Sulfadoxin, Sulfadimethoxin und Kombinationen dieser Wirkstoffe [Susceptibility of bacterial isolates from the equine respiratory tract to trimethoprim, sulfadoxine, sulfadimethoxine and combinations of these compounds]. Tierarztl Prax. 1995 Apr;23(2):148-54. German. [Content Brief]
[3]. Baraff LJ. Emergency medicine-important advances in clinical medicine: single-dose treatment of urinary tract infections. West J Med. 1983 Jan;138(1):89-90. [Content Brief]
[4]. Oguariri RM, et al. Evaluation of the effect of pyrimethamine, an anti-malarial drug, on HIV-1 replication. Virus Res. 2010 Nov;153(2):269-76. [Content Brief]
[5]. Neerja J, et al. Plasmodium yoelii: activity of azithromycin in combination with pyrimethamine or sulfadoxine against blood and sporozoite induced infections in Swiss mice. Exp Parasitol. 2004 Jul-Aug;107(3-4):120-4. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1913 mL | 15.9566 mL | 31.9132 mL | 79.7830 mL |
| 5 mM | 0.6383 mL | 3.1913 mL | 6.3826 mL | 15.9566 mL | |
| 10 mM | 0.3191 mL | 1.5957 mL | 3.1913 mL | 7.9783 mL | |
| 15 mM | 0.2128 mL | 1.0638 mL | 2.1275 mL | 5.3189 mL | |
| 20 mM | 0.1596 mL | 0.7978 mL | 1.5957 mL | 3.9891 mL | |
| 25 mM | 0.1277 mL | 0.6383 mL | 1.2765 mL | 3.1913 mL | |
| 30 mM | 0.1064 mL | 0.5319 mL | 1.0638 mL | 2.6594 mL | |
| 40 mM | 0.0798 mL | 0.3989 mL | 0.7978 mL | 1.9946 mL | |
| 50 mM | 0.0638 mL | 0.3191 mL | 0.6383 mL | 1.5957 mL | |
| 60 mM | 0.0532 mL | 0.2659 mL | 0.5319 mL | 1.3297 mL | |
| 80 mM | 0.0399 mL | 0.1995 mL | 0.3989 mL | 0.9973 mL | |
| 100 mM | 0.0319 mL | 0.1596 mL | 0.3191 mL | 0.7978 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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