Peptidylarginine+Deiminase

By Targets:	Protein Arginine Deiminase (11) Adenosine Receptor (4) Phosphodiesterase (PDE) (4) Reference Standards (2)
By Research Areas:	Cancer (4) Cardiovascular Disease (6) Inflammation/Immunology (7) Metabolic Disease (1) Neurological Disease (4)

Targets Recommended: Protein Arginine Deiminase

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-100514

GSK484 hydrochloride Maximum Cited Publications 49 Publications Verification	Protein Arginine Deiminase	Cardiovascular Disease Inflammation/Immunology Cancer
GSK484 hydrochloride is a selective and reversible peptidylarginine deiminase 4 (PAD4) inhibitor. GSK484 hydrochloride demonstrates high affinity binding to PAD4 with IC₅₀s of 50 nM in the absence of Calcium. In the presence of 2 mM Calcium, notably lower potency (250 nM) is observed.

HY-B1505

Acefylline 1 Publications Verification Theophyllineacetic acid; Theophylline-7-acetic acid	Adenosine Receptor Protein Arginine Deiminase Phosphodiesterase (PDE)	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Acefylline (Theophyllineacetic acid), a xanthine derivative, is an Adenosine Receptor antagonist. Acefylline is a peptidylarginine deiminase (PAD) activator. Acefylline is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline can be used in asthma research .

HY-137655

BMS-P5	Protein Arginine Deiminase	Cancer
BMS-P5 is a selective and orally active peptidylarginine deiminase 4 (PAD4) inhibitor with an IC₅₀ of 98 nM. BMS-P5 shows selective for PAD4 over PAD1, PAD2, and PAD3. BMS-P5 blocks multiple myeloma (MM)-induced neutrophil extracellular trap (NET) formation and delays progression of MM in a syngeneic mouse model .

HY-137655A

BMS-P5 free base	Protein Arginine Deiminase	Cancer
BMS-P5 free base is a selective and orally active peptidylarginine deiminase 4 (PAD4) inhibitor with an IC₅₀ of 98 nM. BMS-P5 free base shows selective for PAD4 over PAD1, PAD2, and PAD3. BMS-P5 free base blocks multiple myeloma (MM)-induced neutrophil extracellular trap (NET) formation and delays progression of MM in a syngeneic mouse model .

HY-B1505A

Acefylline piperazine Theophyllineacetic acid piperazine; Theophylline-7-acetic acid piperazine	Adenosine Receptor Protein Arginine Deiminase Phosphodiesterase (PDE)	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Acefylline (Theophyllineacetic acid) piperazine, a xanthine derivative, is an Adenosine Receptor antagonist. Acefylline piperazine is a peptidylarginine deiminase (PAD) activator. Acefylline piperazine is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline piperazine can be used in asthma research .

HY-B1505R

Acefylline (Standard) Theophyllineacetic acid (Standard); Theophylline-7-acetic acid (Standard)	Reference Standards Adenosine Receptor Protein Arginine Deiminase Phosphodiesterase (PDE)	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Acefylline (Theophyllineacetic acid) (Standard) is the analytical standard of Acefylline (HY-B1505). This product is intended for research and analytical applications. Acefylline (Theophyllineacetic acid), a xanthine derivative, is an Adenosine Receptor antagonist. Acefylline is a peptidylarginine deiminase (PAD) activator. Acefylline is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline can be used in asthma research .

HY-175518

PADI4-IN-1	Protein Arginine Deiminase	Inflammation/Immunology
PADI4-IN-1 is a *potent peptidylarginine deiminase* isoform 4 (PADI4) inhibitor with an IC₅₀** of 1.5 μM and SI (PADI1/PADI4) of 52.1. PADI4-IN-1 can inhibit cellular citrullination events. PADI4-IN-1 can be used for the research of inflammation, such as rheumatoid arthritis .

HY-E70954

Peptidyl Arginine Deiminase, Rabbit	Protein Arginine Deiminase	Metabolic Disease
Peptidyl Arginine Deiminase, Rabbit (EC 3.5.3.15) is the enzyme that converts arginine into citrulline. Calcium is required for peptidylarginine deiminase activity in vitro.

HY-B1505G

Acefylline Theophyllineacetic acid; Theophylline-7-acetic acid	Adenosine Receptor Protein Arginine Deiminase Phosphodiesterase (PDE)	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Acefylline (Theophyllineacetic acid) (GMP), a xanthine derivative, is an Adenosine Receptor antagonist. Acefylline (GMP) is a peptidylarginine deiminase (PAD) activator. Acefylline (GMP) is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline (GMP) can be used in asthma research .

HY-100514R

GSK484 hydrochloride (Standard)	Protein Arginine Deiminase Reference Standards	Cardiovascular Disease Inflammation/Immunology Cancer
GSK484 (hydrochloride) (Standard) is the analytical standard of GSK484 (hydrochloride) (HY-100514). This product is intended for research and analytical applications. GSK484 hydrochloride is a selective and reversible peptidylarginine deiminase 4 (PAD4) inhibitor. GSK484 hydrochloride demonstrates high affinity binding to PAD4 with IC50s of 50 nM in the absence of Calcium. In the presence of 2 mM Calcium, notably lower potency (250 nM) is observed.

HY-P11870

PADI4_7	Protein Arginine Deiminase	Others
PADI4_7 is an inert binder of peptidylarginine deiminase IV (PADI4) with a K_d value of 8 nM. PADI4_7 binds to PADI4 but does not modulate its catalytic activity. PADI4_7 can be functionalized into a biotinylated probe (bio-PADI4_7), which enriches intracellular PADI4 from cell extracts for biochemical analyses, including the identification of PADI4-interacting proteins under resting or activated conditions .

Cat. No.	상품명	Type

HY-B1505G

Acefylline Theophyllineacetic acid; Theophylline-7-acetic acid	Fluorescent Dyes
Acefylline (Theophyllineacetic acid) (GMP), a xanthine derivative, is an Adenosine Receptor antagonist. Acefylline (GMP) is a peptidylarginine deiminase (PAD) activator. Acefylline (GMP) is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline (GMP) can be used in asthma research .

Cat. No.	상품명	Type

HY-B1505G

Acefylline Theophyllineacetic acid; Theophylline-7-acetic acid	Biochemical Assay Reagents
Acefylline (Theophyllineacetic acid) (GMP), a xanthine derivative, is an Adenosine Receptor antagonist. Acefylline (GMP) is a peptidylarginine deiminase (PAD) activator. Acefylline (GMP) is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline (GMP) can be used in asthma research .

Cat. No.	상품명	Target	Research Area

HY-P11870

PADI4_7	Protein Arginine Deiminase	Others
PADI4_7 is an inert binder of peptidylarginine deiminase IV (PADI4) with a K_d value of 8 nM. PADI4_7 binds to PADI4 but does not modulate its catalytic activity. PADI4_7 can be functionalized into a biotinylated probe (bio-PADI4_7), which enriches intracellular PADI4 from cell extracts for biochemical analyses, including the identification of PADI4-interacting proteins under resting or activated conditions .

Cat. No.	상품명	Category	Target	Chemical Structure

HY-B1505

Acefylline 1 Publications Verification Theophyllineacetic acid; Theophylline-7-acetic acid	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification Cancer	Adenosine Receptor Protein Arginine Deiminase Phosphodiesterase (PDE)
Acefylline (Theophyllineacetic acid), a xanthine derivative, is an Adenosine Receptor antagonist. Acefylline is a peptidylarginine deiminase (PAD) activator. Acefylline is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline can be used in asthma research .

HY-B1505R

Acefylline (Standard) Theophyllineacetic acid (Standard); Theophylline-7-acetic acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Adenosine Receptor Protein Arginine Deiminase Phosphodiesterase (PDE)
Acefylline (Theophyllineacetic acid) (Standard) is the analytical standard of Acefylline (HY-B1505). This product is intended for research and analytical applications. Acefylline (Theophyllineacetic acid), a xanthine derivative, is an Adenosine Receptor antagonist. Acefylline is a peptidylarginine deiminase (PAD) activator. Acefylline is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline can be used in asthma research .

Species:	Human (2) Cynomolgus (1)
Tag:	His (3)
Source:	sf9 insect cells (1) E. coli (2)

Cat. No.	Compare	상품명	Species	Source	Image

HY-P704835

	PAD6 Protein, Human (sf9, His) PADI6; PREMBL2; Peptidylarginine Deiminase VI; Peptidylarginine Deiminase Type 6	Human	sf9 insect cells
	PAD6 Protein, Human (sf9, His) is the recombinant human-derived PAD6 protein, expressed by sf9 insect cells, with N-His tag.

HY-P70990

	PADI4 Protein, Human (His) 1 Publications Verification Protein-Arginine Deiminase Type-4; HL-60 PAD; Peptidylarginine Deiminase IV; Protein-arginine Deiminase type IV; PADI4; PADI5; PDI5	Human	E. coli
	PADI4 is a hydrolase that converts arginine residues in histones to citrulline. PADI4 promotes tumor progression by up-regulating the cytokine receptor CXCR2. PADI4 can also cause inflammation and immune responses. PADI4 Protein, Human (His) is the recombinant human-derived PADI4 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P703812

	PADI4 Protein, Cynomolgus (His) Protein-Arginine Deiminase Type-4; HL-60 PAD; Peptidylarginine Deiminase IV; Protein-arginine Deiminase type IV; PADI4; PADI5; PDI5	Cynomolgus	E. coli
	PADI4 Protein, Cynomolgus (His) is the recombinant cynomolgus-derived PADI4 protein, expressed by E. coli, with N-His tag.

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Targets Recommended: Protein Arginine Deiminase

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-B1505G

Acefylline Theophyllineacetic acid; Theophylline-7-acetic acid	Adenosine Receptor Protein Arginine Deiminase Phosphodiesterase (PDE)	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Acefylline (Theophyllineacetic acid) (GMP), a xanthine derivative, is an Adenosine Receptor antagonist. Acefylline (GMP) is a peptidylarginine deiminase (PAD) activator. Acefylline (GMP) is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline (GMP) can be used in asthma research .

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Peptidylarginine+Deiminase

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

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Recombinant Proteins

GMP Molecules

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