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SIM

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (1) Beta-lactamase (1) c-Kit (2) Calcium Channel (1) Epigenetic Reader Domain (2) Fluorescent Dye (2) IFNAR (1) NF-κB (1) PROTACs (1) RET (2) SARS-CoV (1) Small Interfering RNA (siRNA) (4) STING (1) TNF Receptor (1) VEGFR (2)
By Research Areas:	Cancer (4) Infection (2) Inflammation/Immunology (2) Metabolic Disease (1)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (2) siRNAs (4)

Inhibitors & Agonists

Fluorescent Dyes

Inhibitory Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-141438

SIM1 1 Publications Verification	PROTACs Epigenetic Reader Domain	Cancer
SIM1 is a potent von Hippel-Lindau (VHL)-based trivalent PROTAC capable of degradation for all BET family members, with preference for BRD2 degradation (IC₅₀=1.1 nM; Kd=186 nM). SIM1 shows sustained anti-cancer activity .

HY-154965

Simnotrelvir SIM0417; SARS-CoV-2-IN-41	SARS-CoV	Infection
SARS-CoV-2-IN-41 (compound 2) is a potent SARS-CoV-2 3CL ^pro inhibitor with an IC₅₀ value of 0.022 µM. SARS-CoV-2-IN-41 shows antiviral effect .

HY-116116

Tafetinib SIM010603	c-Kit RET VEGFR	Cancer
Tafetinib (SIM010603) is an oral multi-targets receptor tyrosine kinases inhibitor. Tafetinib inhibitsstem cell factor receptor (Kit),vascular endothelial growth factor receptor-2 (VEGFR-2),platelet-derived growth factor receptor-β (PDGFR-β),glial cell line-derived neurotrophic factor receptor (Rearranged during Transfection; RET), andFms-like tyrosine kinase-3 (FLT3)withIC₅₀values between 5.0 and 68.1 nmol/l. Tafetinib inhibits the phosphorylation ofPDGFR-βandVEGFR-2. Tafetinib inhibits endothelial cell proliferation, endothelial cells chemotaxis, and corneal angiogenesis .

HY-19498

WAY-204688 SIM-688	NF-κB	Inflammation/Immunology
WAY-204688 is an estrogen receptor (ER-α) selective, orally active inhibitor of NF-κB transcriptional activity with an IC₅₀ of 122 ± 30 nM for NF-κB-luciferase (NF-κB-luc) in HAECT-1 cells.

HY-D2994

SPY555-BG SNAP-MaP555	Fluorescent Dye	Others
SPY555-BG (SNAP-MaP555) is the benzylguanine derivative of SPY555 fluorophore. SPY555-BG emits light in the orange part of the UV-ViS spectrum. SPY555-BG is fluorogenic, highly cell permeable and well suited for STED and SIM superresolution imaging. SPY555-BG can be imaged with a standard Cy3 filterset. SPY555-BG can be used for widefield, confocal, SIM or STED imaging in living or fixed cells and tissue .

HY-P991195

SIM-0235 SIM1811-03	TNF Receptor	Cancer
SIM-0235 is humanized immunoglobulin G1 (IgG1) monoclonal antibody that targets and inhibits TNFR2, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) ^[1].

HY-131025

Janelia Fluor® 585, SE JF585, SE; JF585, NHS	Fluorescent Dye	Others
Janelia Fluor 585, SE (JF585, SE) is an orange fluorescent dye containing an NHS ester that can be conjugated with primary amine groups. Janelia Fluor 585, SE can be used immediately for structured illumination (SIM) and stimulated emission depletion (STED) imaging and could be converted to photoactivatable derivative for single-molecule localization microscopy (SMLM) experiments . Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.

HY-RS12923

SIM2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SIM2 Human Pre-designed siRNA Set A contains three designed siRNAs for SIM2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SIM2 Human Pre-designed siRNA Set A SIM2 Human Pre-designed siRNA Set A

HY-141438A

*cis-SIM1*	Epigenetic Reader Domain	Others
cis-SIM1 is a negative control of SIM1 .

HY-19083

SIM-6080	Calcium Channel	Metabolic Disease
SIM-6080 is a calcium antagonist and inhibits the proliferation of rat aortic myocytes and reduces aortic atherosclerosis in rabbits .

HY-114588

Tafetinib analogue 1 SIM010603 analogue 1	c-Kit RET VEGFR	Cancer
Tafetinib (SIM010603) analogue 1 is an analog of the tyrosine kinase receptor inhibitor Tafetinib (SIM010603). .

HY-RS12922

SIM1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SIM1 Human Pre-designed siRNA Set A contains three designed siRNAs for SIM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SIM1 Human Pre-designed siRNA Set A SIM1 Human Pre-designed siRNA Set A

HY-RS16865

Stim1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Stim1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Stim1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Stim1 Mouse Pre-designed siRNA Set A Stim1 Mouse Pre-designed siRNA Set A

HY-181526

Sim-9	IFNAR STING	Inflammation/Immunology
Sim-9 is a covalent allosteric inhibitor of interferon regulatory factor 3 (IRF3). Sim-9 binds covalently to the Cys222 residue of IRF3, induces its conformational change, blocks its interactions with TRIF, MAVS and STING, and inhibits IRF3 homodimerization and type I interferon response. Sim-9 exhibits significant anti-inflammatory, organ-protective and survival benefits in mouse models of sepsis and acute pancreatitis. Sim-9 can be used for research related to inflammatory diseases .

HY-175724

MBL-IN-6	Beta-lactamase Bacterial	Infection
MBL-IN-6 (Compound 6d) is a Metallo-β-lactamase (MBL) inhibitor with K_is of 2.6 and 0.08 μM for NDM-1 and VIM-2, respectively. MBL-IN-6 has a synergistic activities with Imipenem (HY-B1369A) on MBL-producing clinical isolates (such as E. coli SI-M001, K. pneumonia T2301 and S. marcescens SI-1591) with MICs of 2-64 μg/mL. MBL-IN-6 does not have off-target effects without ACE-1 inhibition activity. MBL-IN-6 can be used for antimicrobial resistance research .

HY-RS18152

Sim1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sim1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sim1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sim1 Mouse Pre-designed siRNA Set A Sim1 Mouse Pre-designed siRNA Set A

Cat. No.	Product Name	Type

HY-D2994

SPY555-BG SNAP-MaP555	Fluorescent Dyes
SPY555-BG (SNAP-MaP555) is the benzylguanine derivative of SPY555 fluorophore. SPY555-BG emits light in the orange part of the UV-ViS spectrum. SPY555-BG is fluorogenic, highly cell permeable and well suited for STED and SIM superresolution imaging. SPY555-BG can be imaged with a standard Cy3 filterset. SPY555-BG can be used for widefield, confocal, SIM or STED imaging in living or fixed cells and tissue .

SPY555-BG

SNAP-MaP555

Fluorescent Dyes

SPY555-BG (SNAP-MaP555) is the benzylguanine derivative of SPY555 fluorophore. SPY555-BG emits light in the orange part of the UV-ViS spectrum. SPY555-BG is fluorogenic, highly cell permeable and well suited for STED and SIM superresolution imaging. SPY555-BG can be imaged with a standard Cy3 filterset. SPY555-BG can be used for widefield, confocal, SIM or STED imaging in living or fixed cells and tissue .

HY-131025

Janelia Fluor® 585, SE JF585, SE; JF585, NHS	Fluorescent Dyes
Janelia Fluor 585, SE (JF585, SE) is an orange fluorescent dye containing an NHS ester that can be conjugated with primary amine groups. Janelia Fluor 585, SE can be used immediately for structured illumination (SIM) and stimulated emission depletion (STED) imaging and could be converted to photoactivatable derivative for single-molecule localization microscopy (SMLM) experiments . Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.

Janelia Fluor® 585, SE

JF585, SE; JF585, NHS

Fluorescent Dyes

Janelia Fluor 585, SE (JF585, SE) is an orange fluorescent dye containing an NHS ester that can be conjugated with primary amine groups. Janelia Fluor 585, SE can be used immediately for structured illumination (SIM) and stimulated emission depletion (STED) imaging and could be converted to photoactivatable derivative for single-molecule localization microscopy (SMLM) experiments . Janelia Fluor products are licensed under U.S. Pat. Nos. 9,933,417, 10,018,624 and 10,161,932 and other patents from Howard Hughes Medical Institute.

Cat. No.	Product Name	Target	Research Area	Image

HY-P991195

SIM-0235 SIM1811-03	TNF Receptor	Cancer
SIM-0235 is humanized immunoglobulin G1 (IgG1) monoclonal antibody that targets and inhibits TNFR2, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001) ^[1].

SIM2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SIM2 Human Pre-designed siRNA Set A contains three designed siRNAs for SIM2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SIM1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SIM1 Human Pre-designed siRNA Set A contains three designed siRNAs for SIM1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Stim1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Stim1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Stim1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sim1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Sim1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sim1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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