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Results for "

SIN1

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

3

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-101200
    Linsidomine hydrochloride

    SIN-1 chloride
    SIN-1 (chloride) is the active metabolite of molsidomine. SIN-1 (chloride) exhibits potent vasorelaxant effect and inhibition of platelet aggregation [1]. SIN-1 (chloride) decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion .
    Linsidomine hydrochloride
  • HY-139569
    Ebaresdax

    ACP-044

    		 Endogenous Metabolite Neurological Disease
    Ebaresdax (ACP-044) can inhibit peroxynitrite oxidation derived by SIN-1 and peroxynitrite mediated Cytotoxicity with IC50s of 3.7±0.80 and 0.13±0.02 uM, respectively [1].
    Ebaresdax
  • HY-N0649
    Narcissin
    1 Publications Verification

    Narcissoside

    		 EBV Neurological Disease Cancer
    Narcissin (Narcissoside), a flavonol glycoside, exhibits evident scavenging activity against both authentic ONOO - and SIN-1-derived ONOO - with IC50s of 3.5 and 9.6 μM, respectively [1].
    Narcissin
  • HY-126849
    3-Morpholinosydnonimine

    SIN-1; Linsidomine

    		 MDM-2/p53 Cancer
    3-Morpholinosydnonimine (SIN-1; Linsidomine) is a spontaneous ROS/RNS generator and a peroxynitrite donor. 3-Morpholinosydnonimine inhibits hypertrophic chondrocytes activity and induces necrosis. 3-Morpholinosydnonimine induces p53-dependent apoptosis, induces p53 accumulation and activates MAPK phosphorylation [1] .
    3-Morpholinosydnonimine
  • HY-139569A
    Ebaresdax hydrochloride

    ACP-044 hydrochloride

    		 Endogenous Metabolite Neurological Disease
    Ebaresdax (ACP-044) hydrochloride can inhibit peroxynitrite oxidation derived by SIN-1 and peroxynitrite mediated Cytotoxicity with IC50s of 3.7±0.80 and 0.13±0.02 uM, respectively [1].
    Ebaresdax hydrochloride
  • HY-152019
    EGFR/C797S-IN-1

    		EGFR Cancer
    EGFR/C797S-IN-1 is a potent EGFR-C797S inhibitor with an IC50 value of 0.128 µM. EGFR/C797S-IN-1 shows anti-proliferative activity and anti-tumor activity. EGFR/C797S-IN-1 inhibits the expression of p-EGFR in a dose-dependent manner [1].
    EGFR/C797S-IN-<em>1</em>
  • HY-W371164
    C1s-IN-1

    		Complement System Inflammation/Immunology
    C1s-IN-1 (compound A1) is a selective and competitive inhibitor of C1s. C1s-IN-1 binds directly to C1s with a Kd of 9.8 μM [1].
    C<em>1</em>s-IN-<em>1</em>
  • HY-149278
    Complement C1s-IN-1

    		Complement System Inflammation/Immunology
    Complement C1s-IN-1 is a potent, selective, orally active and cross the blood-brain barrier C1s inhibitor with an IC50 value of 36 nM [1].
    Complement C<em>1</em>s-IN-<em>1</em>
  • HY-12379
    NS-2028

    		Guanylate Cyclase Inflammation/Immunology
    NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor with IC50 values of 30 nM and 200 nM for basal and NO-stimulated enzyme activity [1]. NS-2028 inhibits soluble Guanylyl Cyclase activity in homogenates of mouse cerebellum and neuronal NO synthase with IC50 values of 17 nM and 20 nM [1]. NS-2028 inhibits 3-morpholino-sydnonimine (SIN-1)-elicited formation of cyclic GMP in human cultured umbilical vein endothelial cells with an IC50 of 30 nM [1]. NS-2028 is commonly used in the research of nitric oxide signaling pathways, it inhibits NO-dependent relaxant responses in non-vascular smooth muscle completely (1 μM) [1]. NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability .
    NS-2028

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