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Pathways Recommended:	TGF-beta/Smad

Results for "

TGF-β2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	TGF-beta/Smad (5) TGF-β Receptor (1) CCR (2)
By Research Areas:	Cancer (5) Inflammation/Immunology (3) Neurological Disease (1)

6

Inhibitors & Agonists

2

Inhibitory Antibodies

8

Recombinant Proteins

1

Isotope-Labeled Compounds

Targets Recommended: TGF-β Receptor TGF-beta/Smad

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Trabedersen sodium AP 12009 sodium	TGF-beta/Smad	Cancer
Trabedersen sodium is an antisense oligodeoxynucleotide that specifically inhibits *TGF-β2* (TGF-beta/Smad). Trabedersen sodium can be used for the study of malignant brain tumors and other solid tumors overexpressing TGF-β2, such as those of the skin, pancreas and colon .

Fresolimumab 1 Publications Verification GC1008	TGF-β Receptor	Inflammation/Immunology Cancer
Fresolimumab (GC1008) is a high-affinity fully human monoclonal antibody that neutralizes the active form of human TGFβ1, TGFβ2, and TGFβ3. Fresolimumab can be used for the research of cancer and fibrotic diseases .

Pirfenidone 35+ Cited Publications AMR69	TGF-beta/Smad CCR	Inflammation/Immunology Cancer
Pirfenidone (AMR69) is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces *TGF-β2* protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities .

Trabedersen AP 12009	TGF-beta/Smad	Cancer
Trabedersen (AP 12009) is an antisense oligodeoxynucleotide that specifically inhibits *TGF-β2* (TGF-beta/Smad). Trabedersen can be used for the study of malignant brain tumors and other solid tumors overexpressing TGF-β2, such as those of the skin, pancreas and colon .

Lerdelimumab CAT-152	TGF-beta/Smad	Neurological Disease
Lerdelimumab (CAT-152) is an IgG4 human *anti-TGF-β2* recombinant monoclonal antibody. Lerdelimumab can be used as an anti-scarring agent for glaucoma research .

Pirfenidone-d5 AMR69-d₅	TGF-beta/Smad CCR	Inflammation/Immunology Cancer
Pirfenidone-d₅ is a deuterium labeled Pirfenidone. Pirfenidone is an antifibrotic agent that attenuates CCL2 and CCL12 production in fibrocyte cells. Pirfenidone has growth-inhibitory effect and reduces TGF-β2 protein levels in human glioma cell lines. Pirfenidone also has anti-inflammatory activities[1][2][3].

Recombinant Proteins Recommended:

TGF-β2

Species:	Human (4) Rhesus Macaque (1) Mouse (2) Rat (1) Canine (1)
Tag:	His (4) Tag Free (3) Avi (2)
Source:	HEK293 (7) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

	TGF beta 2/TGFB2 Protein, Human (HEK293, Avi) 1 Publications Verification TGFB2; TGFBR2; TGFR2; TbetaR-II; TGFβR2; BB105277; TGF-beta 2; TβR-II; TGF-β 2	Human	HEK293
	In the TGF-beta-2 pathway, TGF beta 2/TGFB2 protein acts as a precursor for Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2), regulating their formation. Crucially, TGF beta 2/TGFB2 maintains TGF-beta-2 in a latent state within the extracellular matrix, forming non-covalent associations with TGF-beta-2. Interactions with 'milieu molecules' like LTBP1 and LRRC32/GARP finely tune TGF-beta-2 activation, playing a pivotal role in controlling this critical signaling pathway. TGF beta 2/TGFB2 Protein, Human (HEK293, Avi) is the recombinant human-derived TGF beta 2/TGFB2 protein, expressed by HEK293, with C-Avi labeled tag. The total length of TGF beta 2/TGFB2 Protein, Human (HEK293, Avi) is 112 a.a., with molecular weight of 14.53 kDa.

	TGF beta 2/TGFB2 Protein, Human 5 Publications Verification TGF-beta-2; Cetermin; G-TSF; TGFB2; Polyergin; rHuTGF-β2	Human	HEK293
	Transforming growth factor-beta 2 (TGF-β2), an extracellular glycosylated protein, is a member of the TGF-β superfamily. TGFβ2 controls key physiological processes including cell migration, proliferation and differentiation via signalling through type I and type II receptors (TGFβR1 and TGFβR2). TGF-β2 is an immune suppressor involved in the development of immune tolerance, and also regulates embryonic development. TGF beta 2/TGFB2 Protein, Human is produced in HEK293 cells, and consists of 112 amino acids (A303-S414).

	TGF beta 2/TGFB2 Protein, Rhesus Macaque (HEK293, His) TGF-beta-2; Cetermin; G-TSF; TGFB2; Polyergin; rHuTGF-β2	Rhesus Macaque	HEK293
	Transforming growth factor-beta 2 (TGF-β2), an extracellular glycosylated protein, is a member of the TGF-β superfamily. TGFβ2 controls key physiological processes including cell migration, proliferation and differentiation via signalling through type I and type II receptors (TGFβR1 and TGFβR2). TGF-β2 is an immune suppressor involved in the development of immune tolerance, and also regulates embryonic development. TGF beta 2/TGFB2 Protein, Rhesus Macaque (HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag. It and consists of 414 amino acids (M1-S414).

	*GARP&Latent TGF* Beta 2 Complex Protein, Human (HEK293, His-Avi)** Garpin; GARP; LRRC32; D11S833E; GARP&Latent TGF B; GARP&TGF B; Cetermin; G-TSF; LAP; TGF-beta-2; TGF Beta 2; GARP&Latent TGF Beta 2	Human	HEK293
	LRRC32, a key regulator of TGF-beta activation, maintains TGFB1, TGFB2, and TGFB3 in a latent state during extracellular storage by binding to Latency-associated peptide (LAP). Competing with LTBP1 for LAP binding, LRRC32 effectively modulates integrin-dependent TGF-beta activation. Its significance spans the regulation of TGF-beta-1 (TGFB1) on activated Tregs' surface and the control of TGF-beta-3 (TGFB3) during palate development, emphasizing LRRC32's intricate role in fine-tuning TGF-beta signaling. Interactions with TGFB1, TGFB2, TGFB3, and LAPTM4B contribute to its regulatory functions. GARP&Latent TGF Beta 2 Complex Protein, Human (HEK293, His-Avi) is a recombinant protein dimer complex containing human-derived GARP&Latent TGF Beta 2 Complex protein, expressed by HEK293, with C-Avi, C-His labeled tag. GARP&Latent TGF Beta 2 Complex Protein, Human (HEK293, His-Avi), has molecular weight of 72-77 kDa(GARP) & 13 kDa & 46-48 kDa(Latent TGF Beta 2), respectively.

	TGF beta 2/TGFB2 Protein, Canine (HEK293, His) TGF-beta-2; Cetermin; G-TSF; TGFB2; Polyergin; rHuTGF-β2	Canine	HEK293
	Transforming growth factor-beta 2 (TGF-β2), an extracellular glycosylated protein, is a member of the TGF-β superfamily. TGFβ2 controls key physiological processes including cell migration, proliferation and differentiation via signalling through type I and type II receptors (TGFβR1 and TGFβR2). TGF-β2 is an immune suppressor involved in the development of immune tolerance, and also regulates embryonic development. TGF beta 2/TGFB2 Protein, Canine (HEK293, His) is produced in HEK293 cells with a C-Terminal His-tag. It and consists of 414 amino acids (M1-S414).

	TGF beta 2/TGFB2 Protein, Mouse/Rat (HEK293) 1 Publications Verification TGFB2; BSC-1 cell growth inhibitor; Cetermin; Glioblastoma-derived T-cell suppressor factor; G-TSF; MGC116892; Polyergin; TGF-beta2; TGF-beta-2; transforming growth factor beta-2	Mouse;Rat	HEK293
	Transforming growth factor-beta 2 (TGF-β2), an extracellular glycosylated protein, is a member of the TGF-β superfamily. TGFβ2 controls key physiological processes including cell migration, proliferation and differentiation via signalling through type I and type II receptors (TGFβR1 and TGFβR2). TGF-β2 is an immune suppressor involved in the development of immune tolerance, and also regulates embryonic development. TGF beta 2/TGFB2 Protein, Mouse/Rat (HEK293) is produced in HEK293 cells, and consists of 112 amino acids (A303-S414).

	TGF beta 2/TGFB2 Protein, Mouse/Rat (HEK293)-1 rMuTGF-β2; TGFB2; LAP	Mouse	HEK293
	TGFB2 Protein, Mouse/Rat (HEK293) performs many cellular functions and has a vital role during embryonic development.

HY-P700151AF

	*Animal-Free TGF* beta 2/TGFB2 Protein, Human (His)** G-TSF; LDS4; TGFB2	Human	E. coli
	In the TGF-beta-2 pathway, TGF beta 2/TGFB2 protein acts as a precursor for Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2), regulating their formation. Crucially, TGF beta 2/TGFB2 maintains TGF-beta-2 in a latent state within the extracellular matrix, forming non-covalent associations with TGF-beta-2. Interactions with 'milieu molecules' like LTBP1 and LRRC32/GARP finely tune TGF-beta-2 activation, playing a pivotal role in controlling this critical signaling pathway. Animal-Free TGF beta 2/TGFB2 Protein, Human (His) is the recombinant human-derived animal-FreeTGF beta 2/TGFB2 protein, expressed by E. coli, with C-His labeled tag. The total length of Animal-Free TGF beta 2/TGFB2 Protein, Human (His) is 112 a.a., with molecular weight of ~13.66 kDa.

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