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Results for "

amide analogs

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Linker (2) Bacterial (1) Biochemical Assay Reagents (3) Cannabinoid Receptor (1) Dopamine Receptor (4) Drug Derivative (4) Drug Intermediate (2) E3 Ligase Ligand-Linker Conjugates (1) Endogenous Metabolite (2) GHR (1) Influenza Virus (1) Isotope-Labeled Compounds (1) LPL Receptor (2) Neurokinin Receptor (1) Nucleoside Antimetabolite/Analog (1) Prostaglandin Receptor (14) PTHR (1) Reference Standards (2) Somatostatin Receptor (1) Thyroid Hormone Receptor (1)
By Research Areas:	Cancer (3) Cardiovascular Disease (3) Endocrinology (8) Infection (1) Inflammation/Immunology (4) Metabolic Disease (5) Neurological Disease (8)
Click Chemistry:	DBCO (4)
Oligonucleotides:	Adenosine (1) Nucleoside Analogs (1)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Isotope-Labeled Compounds

Click Chemistry

Oligonucleotides

Targets Recommended: FAAH

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103423

PAOPA	Dopamine Receptor	Neurological Disease
PAOPA, an analog of L-proline-l-leucine-glycine amide (PLG) peptide, is an allosteric modulator of Dopamine D2 Receptor. PAOPA can effectively reduce behavioral abnormalities in rodent models of schizophrenia. PAOPA increases the high affinity dopamine D2 receptor and promotes its binding to agonists .

HY-108490

VPC 23019	LPL Receptor	Inflammation/Immunology
VPC 23019, an aryl amide-containing Sphingosine 1-phosphate (S1P) analog, is a competitive antagonist at the S1P1 and S1P3 receptors (pK_i= 7.86 and 5.93, respectively) and an agonist at the S1P4 and S1P5 receptors (pEC₅₀= 6.58 and 7.07, respectively) .

HY-W008213

2-Chloro-5-methylbenzoic acid	Biochemical Assay Reagents	Others
2-Chloro-5-methylbenzoic acid can be used to synthesize amide when coupled with 1-Adamantylmethanamine. 2-Chloro-5-methylbenzoic acid can also give analog when coupled with an amine using EDC hydrochlorie and Et₃N in anhydrous CH₂Cl₂ .

HY-P3594

[His1,Nle27] GHRF (1-32), amide, human	GHR	Endocrinology
[His1,Nle27] GHRF (1-32), amide, human is a Growth hormone releasing hormone (GHRH) analog. [His1,Nle27] GHRF (1-32), amide, human has great receptor affinity for GHRHR .

HY-161943

NEU3-IN-1	Influenza Virus	Neurological Disease
NEU3-IN-1 (compound 963) is a NEU3 inhibitor (Ki: 0.12 μM; IC₅₀: 0.31 μM) based on the 2-deoxy-2,3-didehydro-N-acetylneuraminic acid (DANA) scaffold and is a C9 biphenylcarbamate derivative. NEU is a human neuraminidase with 4 isozymes; NEU3-IN-1 is an important tool for studying the function of NEU3 isozymes; its amide and triazole linker analogs are selective for NEU1 and NEU4 isozymes, respectively .

HY-151821

Sulfo DBCO-PEG3-acid	ADC Linker	Others
Sulfo DBCO-PEG3-acid is a click chemistry reagent containing an azide group. Sulfo DBCO-PEG3-acid is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO groups is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain and sulfo group increase water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research use only .

HY-137462

Leucyl-phenylalanine amide L-Leucyl-L-phenylalaninamide	Neurokinin Receptor	Neurological Disease Inflammation/Immunology
Leucyl-phenylalanine amide (L-Leucyl-L-phenylalaninamide) is a dipeptide analog. Leucyl-phenylalanine amide is a ligand of SP_1-7 with a K_i value of 10.2 nM. Leucyl-phenylalanine amide shows no binding activity to human NK-1 or NK-3 receptors .

HY-44630

VH 032 amide-alkylC6-acid (S,R,S)-AHPC-CO-C6-COOH	E3 Ligase Ligand-Linker Conjugates	Cancer
VH 032 amide-alkylC6-acid ((S,R,S)-AHPC-CO-C6-COOH) is a VH032 analog that acts as a ligand for VHL, recruiting von Hippel-Lindau (VHL) protein. VH 032 amide-alkylC6-acid can be used in the synthesis of PROTACs .

HY-114867

(15R)-Bimatoprost 15(R)-17-phenyl trinor PGF2α ethyl amide	Prostaglandin Receptor	Endocrinology
(15R)-Bimatoprost (15(R)-17-phenyl trinor PGF2α ethyl amide) is a prostaglandin analog used to study glaucoma and ocular hypertension. (15R)-Bimatoprost is an isomer of Bimatoprost with an inverted (β) hydroxyl group on C-15 .

HY-P4555

(D-Phe5,Cys6,11,N-Me-D-Trp8)-Somatostatin-14 (5-12) amide	Somatostatin Receptor	Neurological Disease
(D-Phe5,Cys6,11,N-Me-D-Trp8)-Somatostatin-14 (5-12) amide (Compound 4) is a somatostatin analog with K_ds of 0.61, 11.05, 23.5, 1200 and >1000 nM for SSTR5, SSTR3, SSTR2, SSTR1 and SSTR4, respectively .

HY-151820

DBCO-PEG24-acid	ADC Linker	Others
DBCO-PEG24-acid is a click chemistry reagent. DBCO-PEG24-acid is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO groups is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain allows for increased water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research use only .

HY-148840

Sulfo DBCO-PEG3-NHS ester	Biochemical Assay Reagents	Others
Sulfo DBCO-PEG3-NHS ester is a click chemistry reagent containing an azide group. Sulfo DBCO-PEG3-NHS ester is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO group is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain and sulfo group increase water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research use only .

HY-P4818

Human PTH-(1-31) amide	Thyroid Hormone Receptor	Metabolic Disease
Human PTH-(1-31) amide is a PTH analog. Human PTH-(1-31) amide stimulate phosphatidylcholine hydrolysis and stimulates adenylyl cyclase release .

HY-120467

Bima SA Bimatoprost serinol amide	Prostaglandin Receptor	Endocrinology
Bima SA (Bimatoprost serinol amide) is a Prostaglandin analog and has the potential for the research of glaucoma .

HY-W746888

17-Phenyl trinor prostaglandin F2α diethyl amide 17-p-PGF2α-NEt2; 17-Phenyl trinor PGF2α diethyl amide	Prostaglandin Receptor	Cardiovascular Disease
17-Phenyl trinor prostaglandin F2α diethyl amide (17-phenyl trinor PGF2α diethyl amide) is a PGF_2α analog with hypotensive efficacy .

HY-118599

Prostaglandin F2α ethyl amide	Prostaglandin Receptor	Others
Prostaglandin F2α ethyl amide is an analog of Prostaglandin F2α (HY-12956). Prostaglandin F2α ethyl amide is supposed to be potent lowering intraocular pressure (IOP) for its N-ethyl amide group, like Bimatoprost (HY-B0191) .

HY-176021

U-44069 serinol amide	Prostaglandin Receptor	Cardiovascular Disease
U-44069 serinol amide is a derivative of U-44069 (HY-121825). U-44069 serinol amide is a stable analog of the endoperoxide prostaglandin H2 (HY-136500). U-44069 serinol amide is a vasoconstrictor that can induce preglomerular Ca ²⁺ influx .

HY-176022

U-46619 serinol amide	Prostaglandin Receptor	Cardiovascular Disease
U-46619 serinol amide is a derivative of U-46619 (HY-108566). U-46619 serinol amide is a stable analog of Thromboxane A2 (HY-113350) (TXA2). U-46619 serinol amide is a potent TXA2 agonist that can induce platelet shape change and aggregation .

HY-P10309

[Nle8,18,Tyr34]-pTH (3-34) amide (human) [Nle8'18,Tyr34]hPTH (3-34) amide	PTHR	Endocrinology
[Nle8,18,Tyr34]-pTH (3-34) amide human ([Nle8,18,Tyr34]hPTH (3-34) amide) is a parathyroid hormone (PTH) analog .

HY-124219

17-Phenoxy trinor prostaglandin F2α ethyl amide 17-Phenoxy trinor PGF2α ethyl amide	Prostaglandin Receptor	Others
17-Phenoxy trinor prostaglandin F2α ethyl amide (17-Phenoxy trinor PGF2α ethyl amide) is an analog of Bimatoprost (HY-12956). 17-Phenoxy trinor prostaglandin F2α ethyl amide is an agonist for Prostaglandin F2α Receptor (FP receptor). 17-Phenoxy trinor prostaglandin F2α ethyl amide is potent to reduce the intraocular pressure and attenuate the glaucoma .

HY-134110

N-Methylarachidonamide	Endogenous Metabolite	Metabolic Disease
Anandamide (AEA) is an endogenous cannabinoid that binds to both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. The biological actions of AEA are terminated by cellular uptake and hydrolysis of the amide bond by the enzyme fatty acid amide hydrolase. Arachidonoyl-N-methyl amide is an analog of anandamide that binds to the human central cannabinoid (CB1) receptor with a Ki of 60 nM. It inhibits rat glial gap junction cell-cell communication 100% at a concentration of 50 μM.

HY-134055

Arachidonoyl-N,N-dimethyl amide Arachidonic acid-N,N-dimethyl amide	Cannabinoid Receptor	Metabolic Disease
Anandamide (AEA) is an endogenous cannabinoid that binds to both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. The biological actions of AEA are terminated by cellular uptake and hydrolysis of the amide bond by the enzyme fatty acid amide hydrolase. Arachidonoyl-N,N-dimethyl amide is an analog of anandamide that exhibits weak or no binding to the human central cannabinoid (CB1) receptor (Ki >1 μM). It inhibits rat glial gap junction cell-cell communication 100% at a concentration of 50 μM.

HY-120197

17-Phenyl trinor prostaglandin F2α methyl amide	Prostaglandin Receptor	Endocrinology
17-Phenyl trinor prostaglandin F2α methyl amide is a prostaglandin F 2α (PGF 2α) analog that competes with native PGF 2α for receptor binding .

HY-139085A

XL388-C2-amide-PEG9-NH2 hydrochloride	Drug Intermediate	Cancer
XL388-C2-amide-PEG9-NH2 hydrochloride is an intermediate used in the synthesis of C26-linked Rapamycin analog .

HY-139085B

XL388-C2-amide-PEG9-NH2 TFA	Drug Intermediate	Cancer
XL388-C2-amide-PEG9-NH2 TFA is an intermediate used in the synthesis of C26-linked Rapamycin analog .

HY-116833

4-Chloro-3,5-dimethylphenoxyacetic acid	Drug Derivative	Metabolic Disease
4-Chloro-3,5-dimethylphenoxyacetic acid (compound 602 UC) is a product of masked amide bond hydrolysis of auxin analog 602 (compound 602). Auxin can effectively stimulate hypocotyl growth in wild-type seedlings .

HY-152320

Adenosine-2-carboxy methyl amide	Nucleoside Antimetabolite/Analog	Others
Adenosine-2-carboxy methyl amide is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

HY-163376

17-Trifluoromethylphenyl trinor prostaglandin F2α ethyl amide 17-CF3PTPG2α EA	Prostaglandin Receptor	Metabolic Disease
17-Trifluoromethylphenyl trinor prostaglandin F2α ethyl amide (compound 17-CF3PTPG2α EA) is a lipophilic analog of 17-trifluoromethylphenyl trinor PGF2α .

HY-129934S

Latanoprost ethyl amide-d4 Lat-NEt-d₄	Isotope-Labeled Compounds Prostaglandin Receptor	Endocrinology
Latanoprost ethyl amide-d₄ (Lat-NEt-d₄) is deuterium labeled Latanoprost ethyl amide. Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity.1 Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 μg/g corneal tissue/hr. Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides .

HY-117742

DA-7867	Bacterial	Infection
DA-7867 is an antibacterial compound with activity against a wide range of bacteria, including drug-resistant bacteria. DA-7867 shows promising antibacterial activity against some clinically important pathogens, including drug-resistant bacteria. It is an amide analog of Tedizolid (HY-14855), reflecting the potential use of tetrazoles in the development of new antibacterial agents .

HY-124243

N-Cyclopropyl methyl bimatoprost 17-Phenyl trinor prostaglandin F2α cyclopropyl methyl amide	Prostaglandin Receptor	Others
N-Cyclopropyl methyl bimatoprost (17-Phenyl trinor prostaglandin F2α cyclopropyl methyl amide) is an analog of Bimatoprost (HY-12956). N-Cyclopropyl methyl bimatoprost is an agonist for Prostaglandin F2α Receptor (FP receptor). N-Cyclopropyl methyl bimatoprost is potent to reduce the intraocular pressure and attenuate the glaucoma .

HY-176008

Lauric acid leelamide	Drug Derivative	Inflammation/Immunology
Lauric acid leelamide is the lauric acid (C-12) amide analog of Leelamine (HY-W005629). Leelamine exhibits inhibitory activity against pyruvate dehydrogenase kinase (PDHK) with an IC₅₀ value of 9.5 µM. Leelamine derivatives possess anti-inflammatory effects and can inhibit phospholipase A2 activity from various sources .

HY-129934

Latanoprost ethyl amide Lat-NEt	Prostaglandin Receptor	Endocrinology
Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity.1 Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 μg/g corneal tissue/hr. Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides.

HY-148840A

Sulfo DBCO-PEG3-NHS ester TEA	Biochemical Assay Reagents	Others
Sulfo DBCO-PEG3-NHS ester TEA is a click chemistry reagent containing an azide group. Sulfo DBCO-PEG3-NHS ester (TEA) is an analog of DBCO-Acid with PEG linker and a DBCO group. The DBCO group is commonly used for copper-free Click Chemistry reactions due to its strain promoted high energy. The hydrophilic PEG chain and sulfo group increase water solubility. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. Reagent grade, for research use only .

HY-176833

Prostaglandin F2α diethyl amide Dinoprost diethyl amide; PGF2α diethyl amide; PGF2α-NEt2	Drug Derivative	Others
Prostaglandin F2α diethyl amide (Dinoprost diethyl amide) is an analog of Dinoprost (PGF2α) (HY-12956) .

HY-181441

(+)-Cloprostenol methyl amide	Drug Derivative	Others
(+)-Cloprostenol methyl amide is a derivative analog of the carboxylic acid terminus of (+)-Cloprostenol (HY-107381).

HY-W746807

Bimatoprost cyclohexyl amide N-Cyclohexyl-desamethyl bimatoprost; 17-Phenyl trinor prostaglandin F2α cyclohexyl amide	Prostaglandin Receptor	Endocrinology
Bimatoprost cyclohexyl amide (N-Cyclohexyl-desamethyl bimatoprost; 17-Phenyl trinor prostaglandin F2α cyclohexyl amide) is an analog of bimatoprost (HY-B0191). Bimatoprost cyclohexyl amide is an agonist of the prostaglandin F2α receptor. Bimatoprost cyclohexyl amide is used in research on reducing intraocular pressure and glaucoma .

HY-P3048

[Gln4]-Neurotensin	Endogenous Metabolite	Neurological Disease
[Gln4]-Neurotensin is an amide analog that releases luteinizing hormone and follicle-stimulating hormone .

HY-181444

16-Phenoxy tetranor Prostaglandin F2α methyl amide	Prostaglandin Receptor	Others
16-Phenoxy tetranor Prostaglandin F2α methyl amide (16-phenoxy-17,18,19,20-tetranor-PGF2α) is a structural analog of PGF2α (HY-12956), and its binding affinity for the PGF2α (FP) receptor in sheep luteal cells reaches approximately 440% of that of PGF2α .

HY-103423R

PAOPA (Standard)	Reference Standards Dopamine Receptor	Neurological Disease
PAOPA (Standard) is the analytical standard of PAOPA (HY-103423). This product is intended for research and analytical applications. PAOPA, an analog of L-proline-l-leucine-glycine amide (PLG) peptide, is an allosteric modulator of Dopamine D2 Receptor. PAOPA can effectively reduce behavioral abnormalities in rodent models of schizophrenia. PAOPA increases the high affinity dopamine D2 receptor and promotes its binding to agonists .

HY-108490R

VPC 23019 (Standard)	Reference Standards LPL Receptor	Inflammation/Immunology
VPC 23019 (Standard) is the analytical standard of VPC 23019 (HY-108490). This product is intended for research and analytical applications. VPC 23019, an aryl amide-containing Sphingosine 1-phosphate (S1P) analog, is a competitive antagonist at the S1P1 and S1P3 receptors (pK_i= 7.86 and 5.93, respectively) and an agonist at the S1P4 and S1P5 receptors (pEC₅₀= 6.58 and 7.07, respectively) .

HY-181047

FMJ-01-042	Dopamine Receptor	Neurological Disease
FMJ-01-042 is a blood-brain barrier-permeable, low-efficacy partial agonist with high affinity (Kᵢ = 4.33 nM) and exceptional subtype selectivity for the dopamine D4 receptor. FMJ-01-042 exhibits good metabolic stability and is suitable for research on neurological and psychiatric disorders .

HY-181049

FMJ-01-054	Dopamine Receptor	Neurological Disease
FMJ-01-054 is a selective dopamine D4 Receptor (D4R) antagonist with a K_i od 77.7 nM. FMJ-01-054 shows subtype selectivity over D2R and D3R. FMJ-01-054 inhibits D4R-mediated β-arrestin recruitment and cAMP production with IC₅₀ values of 3800 nM and 134 nM, respectively. FMJ-01-054 has desirable plasma half-life and brain exposure in rats. FMJ-01-054 can be used for the research of neurological disorders .

2-Chloro-5-methylbenzoic acid	Biochemical Assay Reagents
2-Chloro-5-methylbenzoic acid can be used to synthesize amide when coupled with 1-Adamantylmethanamine. 2-Chloro-5-methylbenzoic acid can also give analog when coupled with an amine using EDC hydrochlorie and Et₃N in anhydrous CH₂Cl₂ .

Cat. No.	Product Name	Chemical Structure

HY-129934S

Latanoprost ethyl amide-d4

Latanoprost ethyl amide-d₄ (Lat-NEt-d₄) is deuterium labeled Latanoprost ethyl amide. Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity.1 Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 μg/g corneal tissue/hr. Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides .

Cat. No.	Product Name		Classification