XL388-C2-amide-PEG9-NH2 hydrochloride

Name: XL388-C2-amide-PEG9-NH2 hydrochloride
Brand: MedChemExpress
SKU: HY-139085A
Rating: 4.5 (1 reviews)

Cat. No.: HY-139085A Purity: 95.0%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

XL388-C2-amide-PEG9-NH2 hydrochloride is an intermediate used in the synthesis of C26-linked Rapamycin analog.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

XL388-C2-amide-PEG9-NH2 hydrochloride 화학구조

사이즈	재고	수량
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 publication(s) in Google Scholar

Other Forms of XL388-C2-amide-PEG9-NH2 hydrochloride:

XL388-C2-amide-PEG9-NH2 TFA 견적 받기

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

XL388-C2-amide-PEG9-NH2 hydrochloride is an intermediate used in the synthesis of C26-linked Rapamycin analog^[1].

분자량

944.50

화학식

C₄₃H₆₃ClFN₅O₁₃S

Appearance

Oil

Color

Light yellow to yellow

SMILES

O=C(NCCS(=O)(C1=CC=C(C(N2CCOC3=CC=C(C4=CC=C(N)N=C4)C=C3C2)=O)C(C)=C1F)=O)CCOCCOCCOCCOCCOCCOCCOCCOCCN.[H]Cl

선적

Room temperature in continental US; may vary elsewhere.

보관

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

DMSO : 250 mg/mL (264.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 100 mg/mL (105.88 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0588 mL	5.2938 mL	10.5876 mL
5 mM	0.2118 mL	1.0588 mL	2.1175 mL
10 mM	0.1059 mL	0.5294 mL	1.0588 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 4.17 mg/mL (4.42 mM); Clear solution

This protocol yields a clear solution of ≥ 4.17 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (41.7 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 4.17 mg/mL (4.42 mM); Clear solution

This protocol yields a clear solution of ≥ 4.17 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (41.7 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 4.17 mg/mL (4.42 mM); Clear solution

This protocol yields a clear solution of ≥ 4.17 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (41.7 mg/mL) to 900 μL Corn oil, and mix evenly.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (105.88 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 95.0%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (251 KB) HNMR (319 KB) LCMS (271 KB)

Handling Instructions (2659 KB)

References

[1]. Christopher Michael Semko, et al. C26-linked rapamycin analogs as mtor inhibitors. WO2019212991A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	1.0588 mL	5.2938 mL	10.5876 mL	26.4690 mL
	5 mM	0.2118 mL	1.0588 mL	2.1175 mL	5.2938 mL
	10 mM	0.1059 mL	0.5294 mL	1.0588 mL	2.6469 mL
	15 mM	0.0706 mL	0.3529 mL	0.7058 mL	1.7646 mL
	20 mM	0.0529 mL	0.2647 mL	0.5294 mL	1.3235 mL
	25 mM	0.0424 mL	0.2118 mL	0.4235 mL	1.0588 mL
	30 mM	0.0353 mL	0.1765 mL	0.3529 mL	0.8823 mL
	40 mM	0.0265 mL	0.1323 mL	0.2647 mL	0.6617 mL
	50 mM	0.0212 mL	0.1059 mL	0.2118 mL	0.5294 mL
	60 mM	0.0176 mL	0.0882 mL	0.1765 mL	0.4412 mL
	80 mM	0.0132 mL	0.0662 mL	0.1323 mL	0.3309 mL
	100 mM	0.0106 mL	0.0529 mL	0.1059 mL	0.2647 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.