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bile salt hydrolases

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bacterial (5) Biochemical Assay Reagents (1) Endogenous Metabolite (1)
By Research Areas:	Cancer (1) Infection (4) Metabolic Disease (2)

Targets Recommended: Salt-inducible Kinase (SIK) Apical Sodium-Dependent Bile Acid Transporter G protein-coupled Bile Acid Receptor 1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-135747

Gut restricted-7 Maximum Cited Publications 6 Publications Verification GR-7	Bacterial	Infection
Gut restricted-7 (GR-7) is a potent, covalent and orally active pan-bile *salt hydrolase* (BSH) inhibitor. Gut restricted-7 has a tissue-selective and is restricted to the gut. Gut restricted-7 decreases gut bacterial BSHs** and decreases deconjugated bile acid levels in feces of mice .

HY-135659

BSH-IN-1 2 Publications Verification	Bacterial	Infection
BSH-IN-1 is a potent and covalent inhibitor of gut bacterial recombinant bile salt hydrolases (BSHs) with IC₅₀s of 108 nM and 427 nM for B. longum BSH (Gram positive) and B. theta BSH (Gram negative), respectively .

HY-145147

AAA-10 1 Publications Verification	Bacterial	Infection
AAA-10 is an orally active gut bacterial bile salt hydrolases (BSH) inhibitor, with IC₅₀s of 10 nM, 80 nM against B. theta rBSH and B. longum rBSH respectively .

HY-N7761

Trijuganone B Tetrahydro tanshinone I	Bacterial	Cancer
Trijuganone B (Tetrahydro tanshinone I) is a naturally occurring covalent pan-inhibitor of gut microbial bile salt hydrolases that can be isolated from Salvia trijuga. Trijuganone B inhibits total gut microbial bile salt hydrolase activity in live microorganisms and murine gut luminal content. Trijuganone B can be used for the research of bile-acid-related metabolic disorders .

HY-P2958

Choloylglycine hydrolase	Biochemical Assay Reagents	Metabolic Disease
Choloylglycine hydrolase is a conjugated bile salt hydrolase that catalyses the hydrolysis of amide bond in conjugated bile acids. Choloylglycine hydrolase is expressed by intestinal microbiota. Choloylglycine hydrolase can be studied in research on type 2 diabetes .

HY-145147A

AAA-10 formic	Bacterial	Infection
AAA-10 formic is an orally active gut bacterial bile salt hydrolases (BSH) inhibitor, with IC₅₀s of 10 nM, 80 nM against B. theta rBSH and B. longum rBSH, respectively .

HY-E70124D

Esterase, Schizophyllum commune Cholesterol	Endogenous Metabolite	Metabolic Disease
Esterase, Schizophyllum commune Cholesterol (EC 3.1.1.13) belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. Esterase participates in bile acid biosynthesis.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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bile salt hydrolases

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