1. Anti-infection
  2. Bacterial
  3. AAA-10

AAA-10 

Cat. No.: HY-145147
Handling Instructions

AAA-10 is an orally active gut bacterial bile salt hydrolases (BSH) inhibitor, with IC50s of 10 nM, 80 nM against B. theta rBSH and B. longum rBSH respectively.

For research use only. We do not sell to patients.

AAA-10 Chemical Structure

AAA-10 Chemical Structure

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Description

AAA-10 is an orally active gut bacterial bile salt hydrolases (BSH) inhibitor, with IC50s of 10 nM, 80 nM against B. theta rBSH and B. longum rBSH respectively[1].

IC50 & Target

IC50: 10 nM (B. theta rBSH), 80 nM (B. longum rBSH)[1]

In Vitro

AAA-10 (100 μM; 24 h) inhibits BSH activity in bacterial cultures, with IC50s of 74 nM, 901 nM for Gram-negative and Gram-positive bacteria, respectively[1].
AAA-10 (20 μM; 2 h) significantly inhibits deconjugation of glycochenodeoxycholic acid-d4 or taurocholic acid-d4 substrates of human feces[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AAA-10 (30 mg/kg; orally gavage daily for 5 days) decreases the abundances of deoxycholic acid (DCA) and lithocholic acid (LCA) in mice feces starting in day 2-5[1].
AAA-10 (30 mg/kg) displays high colonic exposure and low gut permeability[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 10-11 weeks old male C57Bl/6J mice[1]
Dosage: 30 mg/kg
Administration: Orally gavaged once daily for 5 days
Result: Decreased the abundances of DCA and LCA in mice feces starting in day 2-5.
Displayed high colonic exposure and low gut permeability.
Molecular Weight

472.65

Formula

C₂₅H₄₁FO₅S

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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AAA-10
Cat. No.:
HY-145147
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