Trijuganone B
Based on 1 Customer Validation
Trijuganone B (Tetrahydro tanshinone I) is a naturally occurring covalent pan-inhibitor of gut microbial bile salt hydrolases that can be isolated from Salvia trijuga. Trijuganone B inhibits total gut microbial bile salt hydrolase activity in live microorganisms and murine gut luminal content. Trijuganone B can be used for the research of bile-acid-related metabolic disorders.
For research use only. We do not sell to patients.
- Purity: 96.18%
- CAS No.: 126979-84-8
- Formula: C18H16O3
- Molecular Weight:280.32
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Trijuganone B (Tetrahydro tanshinone I) is a potent pan-inhibitor of purified recombinant EfBSH, LsBSH, BtBSH, CpBSH, and BlBSH enzymes, with IC50 values ranging from 0.28 μM to 1.62 μM[1].
Trijuganone B (50 μM; 2 h) covalently modifies the conserved catalytic Cys2 residue of purified recombinant EfBSH, LsBSH, BtBSH, CpBSH, and BlBSH enzymes, and can modify additional cysteine residues in some of these enzymes[1].
Trijuganone B (63 min) potently inhibits recombinant EfBSH activity in live E. coli BL21 (DE3) cells, with an IC50 of 2.49 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 126979-84-8
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Appearance Solid
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Molecular Weight 280.32
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Formula C18H16O3
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Color Brown to reddish brown
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SMILES
C[C@H]1COC(C2=C(C3=O)C4=C(C(C)=CCC4)C=C2)=C1C3=O
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Synonyms
Tetrahydro tanshinone I
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Xue-Zhang, et al. Discovery of Tetrahydro Tanshinone I as a Naturally Occurring Covalent Pan-Inhibitor Against Gut Microbial Bile Salt Hydrolases. J Agric Food Chem. 2024;72(42):23233-23245. [Content Brief]
[2]. Xuezhao L, et al. Trijuganone A and B: Two New Phenanthrenequinones from Roots of Salvia trijuga. Planta Med. 1990;56(1):87-88. [Content Brief]
[3]. Zhu Z, et al. Rapid separation and identification of phenolic and diterpenoid constituents from Radix Salvia miltiorrhizae by high-performance liquid chromatography diode-array detection, electrospray ionization time-of-flight mass spectrometry and electrospray ionization quadrupole ion trap mass spectrometry. Rapid Commun Mass Spectrom. 2007;21(12):1855-1865. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Trijuganone B Related Classifications
Cat. No.: HY-N7761
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- Trijuganone B
- 126979-84-8
- Tetrahydro tanshinone I
- Bacterial
- Bifidobacterium longum
- E. coli BL21 (DE3)
- Bacteroides thetaiotaomicron
- catalytic cysteine (Cys2)
- bile salt hydrolases
- Lactobacillus salivarius
- bile-acid-related metabolic disorders
- Clostridium perfringens
- Enterococcus faecalis
- murine gut luminal content
- Inhibitor
- inhibitor
- inhibit