intramolecular

By Targets:	Biochemical Assay Reagents (1) Dengue virus (1) Epigenetic Reader Domain (1) Flavivirus (1) Fluorescent Dye (10) Gap Junction Protein (2) Molecular Glues (1) Virus Protease (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (3) Infection (1) Inflammation/Immunology (1) Metabolic Disease (1) Neurological Disease (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-147170

(1,1'-Dipyrenyl)dimethyl ether	Fluorescent Dye	Others
(1,1'-Dipyrenyl)dimethyl ether exhibits intramolecular excimer fluorescence in competition with fluorescence from the locally excited pyrene chromophore. (1,1'-Dipyrenyl)dimethyl ether is soluble in synthetic phospholipid membranes .

HY-132940

(+)-Pileamartine A	Others	Others
(+)-Pileamartine A is a complex alkaloid. (+)-Pileamartine A can be accessed via intramolecular Pd(0)-catalyzed alkene 1,2-aminoarylation reactions .

HY-160528

IBG3	Epigenetic Reader Domain Molecular Glues	Cancer
IBG3 is a dual-JQ1-containing BET degrader that targets protein degradation via intramolecular bivalent glues. IBG3 is a BRD2 and BRD4 bifunctional degrader with DC₅₀ values of 8.6 pM and 6.7 pM, respectively .

HY-D1259

NEP VDP-green (NEP)	Fluorescent Dye	Neurological Disease
NEP (VDP-green (NEP)) is a turn-on fluorescent probe based on the intramolecular charge transfer (ICT) mechanism for sensing vicinal dithiol-containing proteins (VDPs). NEP exhibits high selectivity toward VDPs in live cells and in vivo and displays a strong green fluorescence signal (λ_ex/λ_em=430/535 nm). NEP has the potential for parkinsonism .

HY-163346

TPEG-P

Others Metabolic Disease

TPEG-P is an enzyme-activated intramolecular hydrogen bond (IMHB) enhanced probe, developed for ALP detection in cells and mice models of DILI .

TPEG-P	Others	Metabolic Disease
TPEG-P is an enzyme-activated intramolecular hydrogen bond (IMHB) enhanced probe, developed for ALP detection in cells and mice models of DILI .

HY-112798

PH-002	Others	Neurological Disease
PH-002 is an inhibitor of apolipoprotein (apo) E4 intramolecular domain interaction in neuronal cells that could rescue impairments of mitochondrial motility and neurite outgrowth.

HY-147509

SBP-3	Fluorescent Dye	Others
SBP-3 is a sulfite bioluminescent probe (SBP). The recognition of SBP-3 towards sulfite is based on the mechanism of a sulfite-mediated intramolecular cleavage reaction .

HY-147508

SBP-2	Fluorescent Dye	Others
SBP-2 is a sulfite bioluminescent probe (SBP). The recognition of SBP-2 towards sulfite is based on the mechanism of a sulfite-mediated intramolecular cleavage reaction .

HY-144646

SP-471	Flavivirus Dengue virus Virus Protease	Infection
SP-471 is a potent dengue virus (DENV) protease inhibitor with IC₅₀ value of 18 μM. SP-471 inhibits both intermolecular and intramolecular protease processes of DENV .

HY-101404A

L-Homocysteine thiolactone hydrochloride	Others	Cardiovascular Disease Inflammation/Immunology
L-Homocysteine thiolactone hydrochloride is an intramolecular thioester of Homocysteine. Homocysteine thiolactone hydrochloride prevents translational incorporation of homocysteine into proteins. L-Homocysteine thiolactone hydrochloride can induce elevated HHcy (hyperhomocysteinemia) in mice .

HY-W020768

Fullerene-C60	Biochemical Assay Reagents	Cancer
Fullerene-C60, a representative of carbon nanocompounds, is suggested to be promising agent for application in photodynamic research due to its unique physicochemical properties. Fullerene-C60 probes the intramolecular dynamics of its electron and energy transfer .

HY-W140203

2-(2′-Hydroxyphenyl)benzimidazole	Fluorescent Dye	Others
2-(2′-Hydroxyphenyl)benzimidazole is some of the most extensively studied excited state intramolecular proton transfer (ESIPT) molecules exhibiting normal and tautomer emissions. 2-(2′-Hydroxyphenyl)benzimidazole has been applied as a fluorescent probe in various systems .

HY-D2286

HBT-Fl-BnB	Fluorescent Dye	Others
HBT-Fl-BnB is a fluorescent probe for the ratiometric detection of ONOO ^- in vitro and in vivo. HBT-Fl-BnB consists of an HBT core with Fl groups at the ortho and para positions responding to the zwitterionic excited-state intramolecular proton-transfer (zwitterionic ESIPT) process and a boronic acid pinacol ester with dual roles that block the zwitterionic ESIPT and recognize ONOO ^- .

HY-147181

1,3-Di-(2-pyrenyl)propane	Fluorescent Dye	Others
1,3-Di-(2-pyrenyl)propane is a fluorescent indicator. 1,3-Di-(2-pyrenyl)propane can be used in fluidity of bacterial membrane lipids monitored by intramolecular excimerization. 1,3-Di-(2-pyrenyl)propane shows temperature dependence of fluorescence lifetime distributions .

HY-152073

BETA-1	Fluorescent Dye	Others
BETA-1 is the first twisted intramolecular charge transfer (TICT)-aggregation-induced emission (AIE) integration molecule. BETA-1 emits cyan fluorescence in lipid droplets (LDs) and red fluorescence in mitochondria. BETA-1 can be used for the simultaneous and dual-color imaging of LDs and mitochondria in vivo and in vitro .

HY-100432

LOC14 2 Publications Verification
LOC14 is a potent Protein disulfide isomerase (PDI) inhibitor with EC₅₀ and K_d values of 500 nM and 62 nM, respectively. LOC14 exhibits high stability in mouse liver microsomes and blood plasma, low intrinsic microsome clearance, and low plasma-protein binding . LOC14 inhibits PDIA3 activity, decreases intramolecular disulfide bonds and subsequent oligomerization (maturation) of HA in lung epithelial cells .

HY-P1136

Gap19	Gap Junction Protein	Cardiovascular Disease
Gap19, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 has protective effects against myocardial .

HY-P1136A

Gap19 TFA 3 Publications Verification	Gap Junction Protein	Cardiovascular Disease
Gap19 TFA, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 TFA inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 TFA is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 TFA has protective effects against myocardial .

HY-147507

SBP-1	Fluorescent Dye	Others
SBP-1 is a sulfite bioluminescent probe (SBP). SBP-1 exhibits the excellent responsivity, selectivity and sensitivity towards sulfite. The recognition of SBP-1 towards sulfite is based on the mechanism of a sulfite-mediated intramolecular cleavage reaction. SBP-1 can be used for detection of exogenous and endogenous sulfite in living animal. SBP-1 also possesses a capability for quantitatively detecting sulfite within a certain concentration range in solution .

HY-149203A

MQA-P TFA	Fluorescent Dye	Others
MQA-P is a multifunctional near-infrared (NIR) fluorescent probe that simultaneously detects ONOO ^-, viscosity, and polarity within mitochondria. MQA-P exhibits significant response to ONOO ^-, λ_em=645 nm; and NIR channel at λ_em>704 nm Medium is highly sensitive to viscosity/polarity. MQA-P possesses excited-state intramolecular charge transfer (ESICT) properties that are highly sensitive to polarity by designing the N,N-dimethylamino group as the electron donor and the quinoline cation unit as the electron acceptor. MQA-P is used for ferroptosis or cancer diagnosis in vitro and in vivo via dual-channel images .

Cat. No.	Product Name

HY-L0115V

Asinex Macrocycles Library	10,091 compounds
ASINEX has elaborated a library of diverse macrocycles using an effective tool box of synthetic methods. The resulting scaffolds are novel, tremendously diverse, medchem-relevant, macrocyclic frameworks. Macrocyles tend to be larger than traditional screening molecules which make them perfect discovery tools for targets with shallow or extended binding sites. At the same time, their unique character based on restricted flexibility and ability to form intra-molecular hydrogen bonds allows for design approaches effectively optimizing properties such asaqueous solubility and membrane permeability. Many of these macrocycles have been tested for aqueous and DMSO solubility with cut-offs applied at 10 mM in DMSO and 50 µM in PBS (pH 7.4) followed by PAMPA permeability assay.

Asinex Macrocycles Library

10,091 compounds

ASINEX has elaborated a library of diverse macrocycles using an effective tool box of synthetic methods. The resulting scaffolds are novel, tremendously diverse, medchem-relevant, macrocyclic frameworks.

Macrocyles tend to be larger than traditional screening molecules which make them perfect discovery tools for targets with shallow or extended binding sites. At the same time, their unique character based on restricted flexibility and ability to form intra-molecular hydrogen bonds allows for design approaches effectively optimizing properties such asaqueous solubility and membrane permeability. Many of these macrocycles have been tested for aqueous and DMSO solubility with cut-offs applied at 10 mM in DMSO and 50 µM in PBS (pH 7.4) followed by PAMPA permeability assay.

Cat. No.	Product Name	Type

HY-147170

(1,1'-Dipyrenyl)dimethyl ether	Fluorescent Dyes/Probes
(1,1'-Dipyrenyl)dimethyl ether exhibits intramolecular excimer fluorescence in competition with fluorescence from the locally excited pyrene chromophore. (1,1'-Dipyrenyl)dimethyl ether is soluble in synthetic phospholipid membranes .

HY-D1259

NEP VDP-green (NEP)	Fluorescent Dyes/Probes
NEP (VDP-green (NEP)) is a turn-on fluorescent probe based on the intramolecular charge transfer (ICT) mechanism for sensing vicinal dithiol-containing proteins (VDPs). NEP exhibits high selectivity toward VDPs in live cells and in vivo and displays a strong green fluorescence signal (λ_ex/λ_em=430/535 nm). NEP has the potential for parkinsonism .

HY-149203

MQA-P	Fluorescent Dyes/Probes
MQA-P is a multifunctional near-infrared (NIR) fluorescent probe for simultaneously detecting ONOO ^-, viscosity, and polarity within mitochondria. MQA-P exhibits a remarkable turn-on response to ONOO ^- (λ_em=645 nm) and is highly sensitive to viscosity/polarity in the NIR channel with λ_em>704 nm. MQA-P exhibits excited-state intramolecular charge transfer (ESICT) feature that is highly polarity-sensitive by engineering N,N-dimethylamino as the electron donor and a quinoline cationic unit as the electron acceptor. MQA-P is used for ferroptosis or cancer diagnosis in vitro and in vivo via dual-channel images .

MQA-P

Fluorescent Dyes/Probes

MQA-P is a multifunctional near-infrared (NIR) fluorescent probe for simultaneously detecting ONOO ^-, viscosity, and polarity within mitochondria. MQA-P exhibits a remarkable turn-on response to ONOO ^- (λ_em=645 nm) and is highly sensitive to viscosity/polarity in the NIR channel with λ_em>704 nm. MQA-P exhibits excited-state intramolecular charge transfer (ESICT) feature that is highly polarity-sensitive by engineering N,N-dimethylamino as the electron donor and a quinoline cationic unit as the electron acceptor. MQA-P is used for ferroptosis or cancer diagnosis in vitro and in vivo via dual-channel images .

HY-D2286

HBT-Fl-BnB	Fluorescent Dyes/Probes
HBT-Fl-BnB is a fluorescent probe for the ratiometric detection of ONOO ^- in vitro and in vivo. HBT-Fl-BnB consists of an HBT core with Fl groups at the ortho and para positions responding to the zwitterionic excited-state intramolecular proton-transfer (zwitterionic ESIPT) process and a boronic acid pinacol ester with dual roles that block the zwitterionic ESIPT and recognize ONOO ^- .

Cat. No.	Product Name	Target	Research Area

HY-P1136A

Gap19 TFA 3 Publications Verification	Gap Junction Protein	Cardiovascular Disease
Gap19 TFA, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 TFA inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 TFA is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 TFA has protective effects against myocardial .

HY-P1136

Gap19	Gap Junction Protein	Cardiovascular Disease
Gap19, a peptide derived from nine amino acids of the Cx43 cytoplasmic loop (CL), is a potent and selective connexin 43 (Cx43) hemichannel blocker. Gap19 inhibits hemichannels caused by preventing intramolecular interactions of the C-terminus (CT) with the CL. Gap19 is not blocking GJ channels or Cx40/pannexin-1 hemichannels. Gap19 has protective effects against myocardial .

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