2. Epigenetics PROTAC
  3. Epigenetic Reader Domain Molecular Glues
  4. IBG3

IBG3 is a Molecular glue degrader targeting BRD2 and BRD4, with DC50 values of 8.6 pM and 6.7 pM, respectively. IBG3 binds simultaneously to the tandem bromodomains of BRD2/BRD4, induces intramolecular conformational changes, enhances the affinity of BRD2/BRD4 for DCAF16, and promotes ubiquitination and degradation. IBG3 is applicable to the research of chronic myeloid leukemia.

For research use only. We do not sell to patients.

IBG3

IBG3 Chemical Structure

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
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10 mg In-stock
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Based on 1 publication(s) in Google Scholar

IBG3 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE IBG3

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

IBG3 is a Molecular glue degrader targeting BRD2 and BRD4, with DC50 values of 8.6 pM and 6.7 pM, respectively. IBG3 binds simultaneously to the tandem bromodomains of BRD2/BRD4, induces intramolecular conformational changes, enhances the affinity of BRD2/BRD4 for DCAF16, and promotes ubiquitination and degradation. IBG3 is applicable to the research of chronic myeloid leukemia[1].

IC50 & Target[1]

BRD2

8.6 pM (DC50)

BRD4

6.7 pM (DC50)

In Vitro

IBG3 (6 h) potently degrades BRD4Tandem in KBM7 cells, with a DC50 value of 6.7 pM, which is more potent than IBG1 and dBET6[1].
IBG3 (1 nM-10 μM; 30 min) promotes the formation of the BRD4-DCAF16 ternary complex in vitro, with an EC50 of 32 nM, and exhibits stronger complex-stabilizing activity compared with IBG1[1].
IBG3 (1 pM-100 μM; 5 h) potently degrades BRD2 (DC50 = 8.6 pM) and BRD4 in HEK293 HiBiT knock-in cells, but shows no effect on BRD3, with higher efficiency than IBG1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IBG3 Related Antibodies
Molecular Weight

976.22

Formula

C54H57N9O5S2
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NCC1=CC=C(C2=N[C@@H](CC(OC(C)(C)C)=O)C3=NN=C(C)N3C4=C2C(C)=C(C)S4)C=C1)C5=CC=C(C6=CC=C(C7=N[C@@H](CC(OC(C)(C)C)=O)C8=NN=C(C)N8C9=C7C(C)=C(C)S9)C=C6)C=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (102.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0244 mL 5.1218 mL 10.2436 mL
5 mM 0.2049 mL 1.0244 mL 2.0487 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.53%

SDS (252 KB)

COA (256 KB) HNMR (148 KB) RP-HPLC (171 KB) LCMS (235 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0244 mL 5.1218 mL 10.2436 mL 25.6090 mL
5 mM 0.2049 mL 1.0244 mL 2.0487 mL 5.1218 mL
10 mM 0.1024 mL 0.5122 mL 1.0244 mL 2.5609 mL
15 mM 0.0683 mL 0.3415 mL 0.6829 mL 1.7073 mL
20 mM 0.0512 mL 0.2561 mL 0.5122 mL 1.2804 mL
25 mM 0.0410 mL 0.2049 mL 0.4097 mL 1.0244 mL
30 mM 0.0341 mL 0.1707 mL 0.3415 mL 0.8536 mL
40 mM 0.0256 mL 0.1280 mL 0.2561 mL 0.6402 mL
50 mM 0.0205 mL 0.1024 mL 0.2049 mL 0.5122 mL
60 mM 0.0171 mL 0.0854 mL 0.1707 mL 0.4268 mL
80 mM 0.0128 mL 0.0640 mL 0.1280 mL 0.3201 mL
100 mM 0.0102 mL 0.0512 mL 0.1024 mL 0.2561 mL
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IBG3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IBG3IBG 3IBG-3Epigenetic Reader DomainMolecular GluesBRD2Tandemproteasomal degradationBRD4TandemKBM7 cellsCRL4-DCAF16 complexDCAF16ubiquitinationBRD2HEK293 HiBiT knock-in cellsBRD4Inhibitorinhibitorinhibit

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