SP-471
Based on 1 Customer Validation
SP-471 is a potent dengue virus (DENV) protease inhibitor with IC50 value of 18 μM. SP-471 inhibits both intermolecular and intramolecular protease processes of DENV.
For research use only. We do not sell to patients.
- Purity: 99.79%
- CAS No.: 2768010-39-3
- Formula: C33H26BrN5
- Molecular Weight:572.50
-
Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
-
Bioactive Compound Library Max
HY-L181
-
Bioactive Compound Library
HY-L001
-
Anti-Infection Compound Library
HY-L002
-
Antiviral Compound Library
HY-L027
-
Protease Inhibitor Library
HY-L147
-
Multi-Target Compound Library
HY-L176
-
MCE Bioactive Compound Library
HY-L001V
-
High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
IC50: 18 μM (DENV)[1]
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | CC50 |
100 μM
Compound: 32c; SP-471
|
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability
|
[PMID: 34298282] |
| PBMC | CC50 |
>100 μM
Compound: 32c; SP-471
|
Cytotoxicity against human PBMC assessed as reduction in cell viability
Cytotoxicity against human PBMC assessed as reduction in cell viability
|
[PMID: 34298282] |
SP-471 (10 μM; 48 hours) exhibits an EC50 value of 48.13 μM and CC50 over 100 μM for ADE infection in human PBMCs[1]. [1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:Human peripheral blood mononuclear cells (infected with ADE)[1]
-
Concentration:10 μM
-
Incubation Time:48 hours
-
Result:Resulted in an EC50 value of 48.13 μM and CC50 over 100 μM for ADE infection in human PBMCs.
Chemical Information
-
CAS No. 2768010-39-3
-
Appearance Solid
-
Molecular Weight 572.50
-
Formula C33H26BrN5
-
Color White to off-white
-
SMILES
N=C(C1=CC=CC(C2=CC=C3C(C4=C(N3CC5=CC=CC(Br)=C5)C=CC(C6=CC=CC(C(N)=N)=C6)=C4)=C2)=C1)N
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Purity & Documentation
-
Data Sheet (270 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SP-471 Related Classifications
HY-144646 Related Classifications
Powered by Bioz