SP-471
Based on 1 Customer Validation
SP-471 is a potent dengue virus (DENV) protease inhibitor with IC50 value of 18 μM. SP-471 inhibits both intermolecular and intramolecular protease processes of DENV.
For research use only. We do not sell to patients.
- Purity : 99.79%
- CAS No.: 2768010-39-3
- Formula: C33H26BrN5
- Molecular Weight:572.50
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
IC50: 18 μM (DENV)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | CC50 |
100 μM
Compound: 32c; SP-471
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Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability
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[PMID: 34298282] |
| PBMC | CC50 |
>100 μM
Compound: 32c; SP-471
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Cytotoxicity against human PBMC assessed as reduction in cell viability
Cytotoxicity against human PBMC assessed as reduction in cell viability
|
[PMID: 34298282] |
In Vitro
SP-471 (10 μM; 48 hours) exhibits an EC50 value of 48.13 μM and CC50 over 100 μM for ADE infection in human PBMCs[1]. [1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:Human peripheral blood mononuclear cells (infected with ADE)[1]
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Concentration:10 μM
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Incubation Time:48 hours
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Result:Resulted in an EC50 value of 48.13 μM and CC50 over 100 μM for ADE infection in human PBMCs.
Chemical Information
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CAS No. 2768010-39-3
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Appearance Solid
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Molecular Weight 572.50
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Formula C33H26BrN5
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Color White to off-white
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SMILES
N=C(C1=CC=CC(C2=CC=C3C(C4=C(N3CC5=CC=CC(Br)=C5)C=CC(C6=CC=CC(C(N)=N)=C6)=C4)=C2)=C1)N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SP-471 Related Classifications
HY-144646 Related Classifications
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