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Results for "

miR-21 inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	MicroRNA (15) Akt (1) DNA/RNA Synthesis (2) PPAR (2) Programmed Cell Death 4 (PDCD4) (2) PTEN (1) RIBOTAC (2) TGF-beta/Smad (1)
By Research Areas:	Cancer (18)
Oligonucleotides:	miRNA antagomirs (5) MicroRNAs (10) miRNA inhibitors (5)

Inhibitors & Agonists

Oligonucleotides

Targets Recommended: MicroRNA

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-151516

microRNA-21-IN-2 1 Publications Verification	MicroRNA	Cancer
microRNA-21-IN-2 is a potential *miR-21* inhibitor with an AC₅₀ value of 3.29 μM. microRNA-21-IN-2 can be used for the research of cancer .

HY-130487

miR-21-IN-2	MicroRNA	Cancer
miR-21-IN-2 is a high-affinity *miR-21* inhibitor. miR-21-IN-2 binds to the apical loop region of the *pre-miR-21* hairpin, inhibits Dicer-mediated processing, and thereby blocks the biosynthesis of mature *miR-21. miR-21-IN-2* can be used for the research of microRNA-related diseases .

HY-139682

Dovitinib-RIBOTAC	RIBOTAC DNA/RNA Synthesis PPAR Programmed Cell Death 4 (PDCD4)	Cancer
Dovitinib RIBOTAC is an RNA-targeting RIBOTAC degrader that can specifically bind to and degrade *pre-miR-21. Dovitinib RIBOTAC can inhibit* the metastasis of breast cancer and has anti-tumor activity .

HY-RI00449A

hsa-miR-21-5p antagomir 2 Publications Verification	MicroRNA	Cancer
hsa-miR-21-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-21-5p antagomir hsa-miR-21-5p antagomir

HY-170791

CIB-L43	PTEN TGF-beta/Smad Akt	Cancer
CIB-L43 is an orally active TRBP inhibitor (K_D = 4.78 nM) and enhances disruption of TRBP-Dicer interactions (IC₅₀ = 2.34 μM). CIB-L43 suppresses oncogenic miR-21 biosynthesis, increasing PTEN and Smad7 expression and inhibiting AKT and TGF-β signaling, thereby reducing HCC cell proliferation and migration .

HY-RI00449

hsa-miR-21-5p inhibitor 2 Publications Verification	MicroRNA	Cancer
hsa-miR-21-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-21-5p inhibitor hsa-miR-21-5p inhibitor

HY-139682A

Dovitinib-RIBOTAC TFA	RIBOTAC Programmed Cell Death 4 (PDCD4) DNA/RNA Synthesis PPAR	Cancer
Dovitinib RIBOTAC TFA is an RNA-targeting RIBOTAC degrader that can specifically bind to and degrade *pre-miR-21. Dovitinib RIBOTAC TFA can inhibit* the metastasis of breast cancer and has anti-tumor activity .

HY-164054

MicroRNA modulator-2	MicroRNA	Cancer
MicroRNA modulator-2 (TABLE9 compound 8) is an oxadiazole *miR-21* inhibitor with AC₅₀ of 16.48 μM .

HY-RI00444

hsa-miR-21-3p inhibitor	MicroRNA	Cancer
hsa-miR-21-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-21-3p inhibitor hsa-miR-21-3p inhibitor

HY-164053

miR-21-IN-3	MicroRNA	Cancer
miR-21-IN-3 is a *miR-21* inhibitor with an AC₅₀ of 10.4 μM .

HY-RI02843

mmu-miR-21b inhibitor	MicroRNA	Cancer
mmu-miR-21b inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-miR-21b inhibitor mmu-miR-21b inhibitor

HY-RI00444A

hsa-miR-21-3p antagomir	MicroRNA	Cancer
hsa-miR-21-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-21-3p antagomir hsa-miR-21-3p antagomir

HY-RI02842A

mmu-miR-21a-3p antagomir	MicroRNA	Cancer
mmu-miR-21a-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-21a-3p antagomir mmu-miR-21a-3p antagomir

HY-RI02844

mmu-miR-21c inhibitor	MicroRNA	Cancer
mmu-miR-21c inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-miR-21c inhibitor mmu-miR-21c inhibitor

HY-RI02842

mmu-miR-21a-3p inhibitor	MicroRNA	Cancer
mmu-miR-21a-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-miR-21a-3p inhibitor mmu-miR-21a-3p inhibitor

HY-RI02844A

mmu-miR-21c antagomir	MicroRNA	Cancer
mmu-miR-21c antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-21c antagomir mmu-miR-21c antagomir

HY-RI02843A

mmu-miR-21b antagomir	MicroRNA	Cancer
mmu-miR-21b antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-21b antagomir mmu-miR-21b antagomir

HY-179344

Benzazepinoquinoline-spermine	MicroRNA	Cancer
Benzazepinoquinoline-spermine (Compound PA-3) is an efficient pre-miR-372 complexing agent, and it can specifically inhibit its processing mediated by Dicer. Its IC₅₀ value is 0.58 μM. Benzazepinoquinoline-spermine has a strong affinity for pre-miR-372, with a K_D value of 0.11 μM. Benzazepinoquinoline-spermine also shows high activity against pre-miR-373 (IC₅₀ = 0.29 μM), but significantly reduced inhibitory activity against pre-miR-17, pre-miR-21, and pre-miR-155 (IC₅₀ being 0.84 μM, 1.43 μM, and 1.07 μM respectively). Benzazepinoquinoline-spermine can be used for cancer research .

Cat. No.	Product Name		Classification