Dovitinib-RIBOTAC TFA
Based on 1 Customer Validation
Dovitinib RIBOTAC TFA is an RNA-targeting RIBOTAC degrader that can specifically bind to and degrade pre-miR-21. Dovitinib RIBOTAC TFA can inhibit the metastasis of breast cancer and has anti-tumor activity.
For research use only. We do not sell to patients.
- Purity: 98.35%
- CAS No.: 2759351-69-2
- Formula: C53H57F4N9O12S
- Molecular Weight:1120.13
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
More
Biological Activity
Dovitinib RIBOTAC (0.2-5 μM) TFA can significantly reduce the level of mature miR-21 and inhibit the invasive ability of MDA-MB-231 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231
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Concentration:0.2, 1 and 5 μM
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Incubation Time:/
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Result:Significantly reduced the level of miR-21-5p.
Dovitinib RIBOTAC (56 mg/kg; 腹腔注射; 隔天一次; 42 天) TFA 在 Alport 综合征小鼠模型中具有改善作用，可稳定尿白蛋白浓度，降低肾脏中成熟和前体 miR-21 水平，提高 PPARα 蛋白水平[1]。
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:MDA-MB-231-Luc cells treated female NOD/SCID mice[1]
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Dosage:56 mg/kg
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Administration:Intraperitoneal injection; every other day; 30 days
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Result:Inhibited breast cancer metastasis.
Decreased the number of lung nodules.
Significantly diminished miR-21 and pre-miR-21 expression.
Derepressed PDCD4 expression while having no effect on ERK or pERK levels.
Chemical Information
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CAS No. 2759351-69-2
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Appearance Solid
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Molecular Weight 1120.13
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Formula C53H57F4N9O12S
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Color Light yellow to yellow
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SMILES
O=C1C(C2=NC3=CC(N4CCN(CCNC(NCCOCCOCCOCCOC5=C(O)C=C(/C=C6C(C(C(OCC)=O)=C(NC7=CC=CC=C7)S/6)=O)C=C5)=O)CC4)=CC=C3N2)=C(N)C8=C(C=CC=C8F)N1.OC(C(F)(F)F)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 100 mg/mL (89.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.8928 mL | 4.4638 mL | 8.9275 mL | 22.3188 mL |
| 5 mM | 0.1786 mL | 0.8928 mL | 1.7855 mL | 4.4638 mL | |
| 10 mM | 0.0893 mL | 0.4464 mL | 0.8928 mL | 2.2319 mL | |
| 15 mM | 0.0595 mL | 0.2976 mL | 0.5952 mL | 1.4879 mL | |
| 20 mM | 0.0446 mL | 0.2232 mL | 0.4464 mL | 1.1159 mL | |
| 25 mM | 0.0357 mL | 0.1786 mL | 0.3571 mL | 0.8928 mL | |
| 30 mM | 0.0298 mL | 0.1488 mL | 0.2976 mL | 0.7440 mL | |
| 40 mM | 0.0223 mL | 0.1116 mL | 0.2232 mL | 0.5580 mL | |
| 50 mM | 0.0179 mL | 0.0893 mL | 0.1786 mL | 0.4464 mL | |
| 60 mM | 0.0149 mL | 0.0744 mL | 0.1488 mL | 0.3720 mL | |
| 80 mM | 0.0112 mL | 0.0558 mL | 0.1116 mL | 0.2790 mL |
Dovitinib-RIBOTAC TFA Related Classifications
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