Dovitinib-RIBOTAC
Based on 1 Customer Validation
Dovitinib RIBOTAC is an RNA-targeting RIBOTAC degrader that can specifically bind to and degrade pre-miR-21. Dovitinib RIBOTAC can inhibit the metastasis of breast cancer and has anti-tumor activity.
For research use only. We do not sell to patients.
- Purity: 99.31%
- CAS No.: 2759351-68-1
- Formula: C51H56FN9O10S
- Molecular Weight:1006.11
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Storage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
More
Biological Activity
Dovitinib RIBOTAC (0.2-5 μM) can significantly reduce the level of mature miR-21 and inhibit the invasive ability of MDA-MB-231 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231
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Concentration:0.2, 1 and 5 μM
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Incubation Time:/
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Result:Significantly reduced the level of miR-21-5p.
Dovitinib RIBOTAC (56 mg/kg; intraperitoneal injection; every other day; 42 days) has an ameliorative effect in a mouse model of Alport Syndrome. It can stabilize the urine albumin concentration, reduce the levels of mature and precursor miR-21 in the kidneys, and increase the PPARα protein level[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:MDA-MB-231-Luc cells treated female NOD/SCID mice[1]
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Dosage:56 mg/kg
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Administration:Intraperitoneal injection; every other day; 30 days
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Result:Inhibited breast cancer metastasis.
Decreased the number of lung nodules.
Significantly diminished miR-21 and pre-miR-21 expression.
Derepressed PDCD4 expression while having no effect on ERK or pERK levels.
Chemical Information
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CAS No. 2759351-68-1
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Appearance Solid
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Molecular Weight 1006.11
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Formula C51H56FN9O10S
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Color Light yellow to yellow
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SMILES
O=C1C(C2=NC3=CC(N4CCN(CCNC(NCCOCCOCCOCCOC5=C(O)C=C(/C=C6C(C(C(OCC)=O)=C(NC7=CC=CC=C7)S/6)=O)C=C5)=O)CC4)=CC=C3N2)=C(N)C8=C(C=CC=C8F)N1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 130 mg/mL (129.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9939 mL | 4.9696 mL | 9.9393 mL | 24.8482 mL |
| 5 mM | 0.1988 mL | 0.9939 mL | 1.9879 mL | 4.9696 mL | |
| 10 mM | 0.0994 mL | 0.4970 mL | 0.9939 mL | 2.4848 mL | |
| 15 mM | 0.0663 mL | 0.3313 mL | 0.6626 mL | 1.6565 mL | |
| 20 mM | 0.0497 mL | 0.2485 mL | 0.4970 mL | 1.2424 mL | |
| 25 mM | 0.0398 mL | 0.1988 mL | 0.3976 mL | 0.9939 mL | |
| 30 mM | 0.0331 mL | 0.1657 mL | 0.3313 mL | 0.8283 mL | |
| 40 mM | 0.0248 mL | 0.1242 mL | 0.2485 mL | 0.6212 mL | |
| 50 mM | 0.0199 mL | 0.0994 mL | 0.1988 mL | 0.4970 mL | |
| 60 mM | 0.0166 mL | 0.0828 mL | 0.1657 mL | 0.4141 mL | |
| 80 mM | 0.0124 mL | 0.0621 mL | 0.1242 mL | 0.3106 mL | |
| 100 mM | 0.0099 mL | 0.0497 mL | 0.0994 mL | 0.2485 mL |
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