2. PROTAC
  3. PROTACs
  4. Dovitinib-RIBOTAC

Dovitinib RIBOTAC is a targeted RNA degrader that cleaves pre-miR-21 with enhanced potency and selectivity.

For research use only. We do not sell to patients.

Dovitinib-RIBOTAC Chemical Structure

Dovitinib-RIBOTAC Chemical Structure

CAS No. : 2759351-68-1

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1 mg USD 400 In-stock
5 mg USD 1280 In-stock
10 mg USD 2050 In-stock
25 mg USD 4250 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Dovitinib-RIBOTAC:

Dovitinib-RIBOTAC Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

Dovitinib RIBOTAC is a targeted RNA degrader that cleaves pre-miR-21 with enhanced potency and selectivity.

IC50 & Target

Cereblon

 

Molecular Weight

1006.11

Formula

C51H56FN9O10S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C(C2=NC3=CC(N4CCN(CCNC(NCCOCCOCCOCCOC5=C(O)C=C(/C=C6C(C(C(OCC)=O)=C(NC7=CC=CC=C7)S/6)=O)C=C5)=O)CC4)=CC=C3N2)=C(N)C8=C(C=CC=C8F)N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 130 mg/mL (129.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9939 mL 4.9696 mL 9.9393 mL
5 mM 0.1988 mL 0.9939 mL 1.9879 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9939 mL 4.9696 mL 9.9393 mL 24.8482 mL
5 mM 0.1988 mL 0.9939 mL 1.9879 mL 4.9696 mL
10 mM 0.0994 mL 0.4970 mL 0.9939 mL 2.4848 mL
15 mM 0.0663 mL 0.3313 mL 0.6626 mL 1.6565 mL
20 mM 0.0497 mL 0.2485 mL 0.4970 mL 1.2424 mL
25 mM 0.0398 mL 0.1988 mL 0.3976 mL 0.9939 mL
30 mM 0.0331 mL 0.1657 mL 0.3313 mL 0.8283 mL
40 mM 0.0248 mL 0.1242 mL 0.2485 mL 0.6212 mL
50 mM 0.0199 mL 0.0994 mL 0.1988 mL 0.4970 mL
60 mM 0.0166 mL 0.0828 mL 0.1657 mL 0.4141 mL
80 mM 0.0124 mL 0.0621 mL 0.1242 mL 0.3106 mL
100 mM 0.0099 mL 0.0497 mL 0.0994 mL 0.2485 mL
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Dovitinib-RIBOTAC Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dovitinib-RIBOTAC2759351-68-1PROTACsInhibitorinhibitorinhibit

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