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Results for "

miR155

" in MedChemExpress (MCE) Product Catalog:

By Targets:	MicroRNA (15) Apoptosis (1) c-Myc (1) DNA Alkylator/Crosslinker (1) PROTACs (1) Small Interfering RNA (siRNA) (1) Transthyretin (TTR) (1)
By Research Areas:	Cancer (18)
Oligonucleotides:	miRNA mimics (3) miRNA antagomirs (3) miRNA agomirs (3) MicroRNAs (12) miRNA inhibitors (3) Antisense Oligonucleotides (3)

Inhibitors & Agonists

Peptides

Oligonucleotides

Targets Recommended: MicroRNA

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153713

MYC-RIBOTAC 1 Publications Verification	PROTACs c-Myc Apoptosis	Cancer
MYC-RIBOTAC is a nucleic acid-targeting degrader (ribonuclease-targeting chimera, RIBOTAC) that targets the MYC internal ribosome entry site (IRES). MYC-RIBOTAC contains a MYC mRNA binding component and a small molecule that recruits and locally activates RNAse L1. MYC-RIBOTAC reduces MYC mRNA and protein expression levels, induces cell apoptosis, and can be used for antitumor research . MYC-RIBOTAC consists of pre-miR-155 binder Anticancer agent 167 (HY-156839), RNA binder NCI-B16 (HY-156215), and Linker Amino-PEG4-alcohol (HY-W008005).

HY-R00316

*hsa-miR-155-5p mimic* 1 Publications Verification	MicroRNA	Cancer
hsa-miR-155-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-155-5p mimic hsa-miR-155-5p mimic

HY-132601A

Cobomarsen sodium MRG-106 sodium	MicroRNA	Cancer
Cobomarsen sodium is an oligonucleotide inhibitor of *miR-155. Cobomarsen sodium inhibits multiple gene pathways associated with cell survival (including JAK/STAT, MAPK/ERK* and PI3K/AKT). Cobomarsen sodium can be used for the research of B-cell lymphoma .

HY-RI02691A

*mmu-miR-155-5p antagomir*	MicroRNA	Cancer
mmu-miR-155-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-155-5p antagomir mmu-miR-155-5p antagomir

HY-R02691

*mmu-miR-155-5p mimic*	MicroRNA	Cancer
mmu-miR-155-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

mmu-miR-155-5p mimic mmu-miR-155-5p mimic

HY-RI00316

*hsa-miR-155-5p inhibitor*	MicroRNA	Cancer
hsa-miR-155-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-155-5p inhibitor hsa-miR-155-5p inhibitor

HY-RI02691

*mmu-miR-155-5p inhibitor*	MicroRNA	Cancer
mmu-miR-155-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

mmu-miR-155-5p inhibitor mmu-miR-155-5p inhibitor

HY-132601

Cobomarsen MRG-106	MicroRNA	Cancer
Cobomarsen (MRG-106) is an oligonucleotide inhibitor of *miR-155. Cobomarsen inhibits multiple gene pathways associated with cell survival (including JAK/STAT, MAPK/ERK* and PI3K/AKT). Cobomarsen can be used for the research of B-cell lymphoma .

HY-RI00316A

*hsa-miR-155-5p antagomir*	MicroRNA	Cancer
hsa-miR-155-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-155-5p antagomir hsa-miR-155-5p antagomir

HY-R02691A

*mmu-miR-155-5p agomir*	MicroRNA	Cancer
mmu-miR-155-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

mmu-miR-155-5p agomir mmu-miR-155-5p agomir

HY-132601C

Cobomarsen scrambled control	Small Interfering RNA (siRNA)	Cancer
Cobomarsen scrambled control is the negative control form of Cobomarsen (HY-132601), with the sequence: ACAUCAUAGUGACU. The modification method is the same as that of Cobomarsen. Cobomarsen sodium is an oligonucleotide inhibitor of miR-155 and can be used in the research of B-cell lymphoma.

HY-R00315

*hsa-miR-155-3p mimic*	MicroRNA	Cancer
hsa-miR-155-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-155-3p mimic hsa-miR-155-3p mimic

HY-RI00315

*hsa-miR-155-3p inhibitor*	MicroRNA	Cancer
hsa-miR-155-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-155-3p inhibitor hsa-miR-155-3p inhibitor

HY-R00316A

*hsa-miR-155-5p agomir*	MicroRNA	Cancer
hsa-miR-155-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-155-5p agomir hsa-miR-155-5p agomir

HY-RI00315A

*hsa-miR-155-3p antagomir*	MicroRNA	Cancer
hsa-miR-155-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-155-3p antagomir hsa-miR-155-3p antagomir

HY-P11698

Guanidino-G-Clamp-PNA	DNA Alkylator/Crosslinker Transthyretin (TTR)	Cancer
Guanidino-G-Clamp-PNA is a highly efficient sequence-specific RNA binder and gene silencer. Guanidino-G-Clamp-PNA precisely targets such targets as *miR-155* or transthyretin (TTR) mRNA through base pairing: the former regulates tumor-related signaling pathways by reducing microRNA activity, while the latter inhibits the translation of harmful proteins via steric hindrance. Guanidino-G-Clamp-PNA effectively stabilizes DNA/RNA duplexes, induces cancer cell apoptosis, and suppresses tumor growth. In addition, Guanidino-G-Clamp-PNA can be conjugated with targeting ligands to improve tissue-specific delivery and reduce in vivo adverse reactions, and it can also enhance the splicing regulation efficacy of other oligonucleotide platforms (such as PMO) when integrated into them. Guanidino-G-Clamp-PNA is applicable to the research of various diseases including diffuse large B-cell lymphoma and hereditary transthyretin-related amyloidosis .

HY-R00315A

*hsa-miR-155-3p agomir*	MicroRNA	Cancer
hsa-miR-155-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-155-3p agomir hsa-miR-155-3p agomir

HY-179344

Benzazepinoquinoline-spermine	MicroRNA	Cancer
Benzazepinoquinoline-spermine (Compound PA-3) is an efficient pre-miR-372 complexing agent, and it can specifically inhibit its processing mediated by Dicer. Its IC₅₀ value is 0.58 μM. Benzazepinoquinoline-spermine has a strong affinity for pre-miR-372, with a K_D value of 0.11 μM. Benzazepinoquinoline-spermine also shows high activity against pre-miR-373 (IC₅₀ = 0.29 μM), but significantly reduced inhibitory activity against pre-miR-17, pre-miR-21, and pre-miR-155 (IC₅₀ being 0.84 μM, 1.43 μM, and 1.07 μM respectively). Benzazepinoquinoline-spermine can be used for cancer research .

Cat. No.	Product Name	Target	Research Area