2. Epigenetics
  3. MicroRNA
  4. Cobomarsen

Cobomarsen  (Synonyms: MRG-106)

Cat. No.: HY-132601 Purity: 92.58%
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Cobomarsen (MRG-106) is an oligonucleotide inhibitor of miR-155. Cobomarsen inhibits multiple gene pathways associated with cell survival (including JAK/STAT, MAPK/ERK and PI3K/AKT). Cobomarsen can be used for the research of B-cell lymphoma.

For research use only. We do not sell to patients.

RNA, (P-thio)((2'-O,4'-C-methylene)m5C-dA-(2'-O,4'-C-methylene)m5C-dG-dA- (2'-O,4'-C-methylene)m5U-(2'-O,4'-C-methylene)m5U-dA-(2'-O,4'-Cmethylene)G-dC-(2'-O,4'-C-methylene)A-(2'-O,4'-C-methylene)m5U-(2'-O,4'-Cmethylene)m5U-(2'-O,4'-C-methylene)A)

Cobomarsen Chemical Structure

CAS No. : 1848257-52-2

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1 mg USD 408 In-stock
5 mg USD 959 In-stock
10 mg USD 1540 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Cobomarsen Related Antibodies

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Description

Cobomarsen (MRG-106) is an oligonucleotide inhibitor of miR-155. Cobomarsen inhibits multiple gene pathways associated with cell survival (including JAK/STAT, MAPK/ERK and PI3K/AKT). Cobomarsen can be used for the research of B-cell lymphoma[1][2].

In Vitro

Cobomarsen (10 μM; 48-96 h) reduces cell proliferation and induces apoptosis in U2932, OCI-LY3, and RCK8 cells[2].
Cobomarsen (10 μM; 72 h) significantly increases the expression of the four direct targets in the cell lines that overexpress miR-155[1].
Cobomarsen (10 μM; 12 days) reduces cellular proliferation and induces apoptosis in MF and HTLV-1+ CTCL cells[1].
Cobomarsen (10-50 μM; 7 days) reduces phosphorylation of the downstream signalling proteins AKT, ERK1/2, and STAT-3 in primary human activated T cells or MF cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cobomarsen Related Antibodies

Cell Proliferation Assay[2]

Cell Line: U2932, OCI-LY3 and RCK8 cells
Concentration: 10 μM
Incubation Time: 48, 72, 96 hours
Result: Concentration-dependently inhibited cell phosphorylation.

Apoptosis Analysis[2]

Cell Line: U2932, OCI-LY3 and RCK8 cells
Concentration: 10 μM
Incubation Time: 96 hours
Result: Triggered a significant induction of late apoptosis in all cell lines.
In Vivo

Cobomarsen (1 mg/kg; i.v. on days 0, 2, 4, and 7) inhibits tumor growth in mice carrying U2932 cells xenografts[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Five-to-six weeks old female NSG mice injected with U2932 cells
Dosage: 1 mg/kg
Administration: I.v. on days 0, 2, 4, and 7
Result: Reduced tumor growth most significantly at day 7 and day 10.
Clinical Trial
Molecular Weight

4736.00

CAS No.
Appearance

Solid

Color

White to off-white

Sequence

RNA, (P-thio)((2'-O,4'-C-methylene)m5C-dA-(2'-O,4'-C-methylene)m5C-dG-dA- (2'-O,4'-C-methylene)m5U-(2'-O,4'-C-methylene)m5U-dA-(2'-O,4'-Cmethylene)G-dC-(2'-O,4'-C-methylene)A-(2'-O,4'-C-methylene)m5U-(2'-O,4'-Cmethylene)m5U-(2'-O,4'-C-methylene)A)
SMILES

[Cobomarsen]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (21.11 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2111 mL 1.0557 mL 2.1115 mL
5 mM 0.0422 mL 0.2111 mL 0.4223 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.2111 mL 1.0557 mL 2.1115 mL 5.2787 mL
5 mM 0.0422 mL 0.2111 mL 0.4223 mL 1.0557 mL
10 mM 0.0211 mL 0.1056 mL 0.2111 mL 0.5279 mL
15 mM 0.0141 mL 0.0704 mL 0.1408 mL 0.3519 mL
20 mM 0.0106 mL 0.0528 mL 0.1056 mL 0.2639 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Cobomarsen Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cobomarsen1848257-52-2MRG-106MRG106MRG 106MicroRNAmiRNAoligonucleotidemiR-155JAK/STATMAPK/ERKPI3K/AKTB-celllymphomaInhibitorinhibitorinhibit

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