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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
myelocytic
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "myelocytic" in MCE Product Catalog:
14
14 Publications Verification
Synonyms: Couroupitine B; Indigo red; Indigopurpurin
Target:
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Filanesib (ARRY-520) is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor, with an IC50 of 6 nM for human KSP. Filanesib induces cell death by apoptosis in vitro. Filanesib has potent anti-proliferative activity .
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Filanesib (ARRY-520) hydrochloride is a selective and noncompetitive kinesin spindle protein (KSP) inhibitor, with an IC50 of 6 nM for human KSP. Filanesib induces cell death by apoptosis in vitro. Filanesib has potent anti-proliferative activity .
Cat. No.: HY-N0117A
CAS No.: 906748-38-7
Synonyms: (Z)-Couroupitine B; (Z)-Indigo red; (Z)-Indigopurpurin
(Z)-Indirubin is an isomer of Indirubin (HY-N0117). Indirubin is a bis-indole alkaloid and has emarkable anticancer activity against chronic myelocytic leukemia .
Cat. No.: HY-177023
CAS No.: 103137-88-8
Target:
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Ap5dT is a cytosolic thymidine kinase and mitochondrial enzyme inhibitor with Kis of 0.12 μM and 0.50 μM, respectively. Ap5dT can be used for the study of acute myelocytic leukemia .
Synonyms: Couroupitine B (Standard); Indigo red (Standard); Indigopurpurin (Standard)
Category:
Target:
Cat. No.: HY-15187B
CAS No.: 1781834-99-8
Synonyms: ARRY-520 TFA
Filanesib TFA (ARRY-520 TFA) is a selective kinesin spindle protein (KSP) inhibitor, with an IC50 of 6 nM for human KSP. Filanesib TFA induces cell death by apoptosis in vitro. Filanesib TFA has potent anti-proliferative activity .
Cat. No.: HY-W739369
CAS No.: 15130-04-8
Target:
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Cyanocobalamin-e-methylamide is a Vitamin B12 (HY-B0315) analogue. Cyanocobalamin-e-methylamide exerts a plasma blocking effect on 57Co-cyanocobalamin. Cyanocobalamin-e-methylamide can be used for the research of chronic myelocytic leukaemia .
Cat. No.: HY-181800
SHP2-IN-47 is a selective and potent SHP2 inhibitor with an IC50 of 0.80 μM. SHP2-IN-47 exhibits potent inhibitory activity against SHP2 E76K (IC50 = 0.37 μM). SHP2-IN-47 functionally inhibits protein tyrosine phosphatase domains and downregulates SHP2-mediated phosphorylation of AKT and ERK. SHP2-IN-47 induces apoptosis and suppresses proliferation of cancer cells. SHP2-IN-47 can be used for the research of cancer, such as acute myelocytic leukemia .
Cat. No.: HY-184760
CAS No.: 3022872-60-9
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Tubulin polymerization-IN-93 is a β-tubulin polymerization inhibitor. Tubulin polymerization-IN-93 disrupts the microtubule network structure. Tubulin polymerization-IN-93 activates the spindle assembly checkpoint and promotes Mitotic catastrophe. Tubulin polymerization-IN-93 activates the mitochondrial Apoptotic pathway. Tubulin polymerization-IN-93 exhibits anticancer activity against acute myeloid leukemia .
Cat. No.: HY-187636
CAS No.: 18921-70-5
Research Areas:
Methasquin is an antifolate dihydrofolate reductase inhibitor (antifolate dihydrofolate reductase) with an IC50 of 1.3 nM against dihydrofolate reductase derived from human leukemia cells. Methasquin binds to dihydrofolate reductase, depletes tetrahydrofolate derivatives, disrupts thymidylate synthesis and inhibits DNA synthesis. Methasquin can be used in leukemia-related research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
