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pathogen+infection

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aminoacyl-tRNA Synthetase (3) Bacterial (4) Drug Metabolite (1) Endogenous Metabolite (1) Fungal (1) Interleukin Related (2) MAP4K (1) Phytohormone (2) Toll-like Receptor (TLR) (1)
By Research Areas:	Cancer (1) Infection (9) Inflammation/Immunology (1)

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Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N11420

Coronatine	Bacterial Phytohormone	Others
Coronatine is a plant growth regulator that mimicks the jasmonic acid-isoleucine conjugate (JA-Ile), targets the jasmonic acid receptor COI1, activates the jasmonic acid signaling pathway, thereby inhibiting salicylic acid (SA)-dependent defense responses. Coronatine antagonizes the stomatal closure, induces plant cell necrosis and chlorosis, interfers with plant hormone balance, thereby promoting pathogen infection .

HY-12479A

Epetraborole hydrochloride 2 Publications Verification GSK2251052 hydrochloride	Bacterial Aminoacyl-tRNA Synthetase	Infection
Epetraborole (GSK2251052) hydrochloride is a novel leucyl-tRNA synthetase (LeuRS) inhibitor (IC₅₀=0.31 μM), thereby inhibiting protein synthesis. Epetraborole hydrochloride can be used in multidrug-resistant gram-negative pathogens infection research .

HY-W585952

Salicylic acid 2-O-β-D-glucoside SA-2-O-β-D-glucoside	Drug Metabolite	Infection
Salicylic acid 2-O-β-D-glucoside (SA-2-O-β-D-glucoside) is the glucose-conjugated product of Salicylic Acid (HY-B0167) in plants. Salicylic acid 2-O-β-D-glucoside belongs to an inactive storage form. Salicylic acid 2-O-β-D-glucoside can be used in studies of plant pathogen infection .

HY-144093

HPK1/GLK-IN-1	MAP4K	Infection
HPK1/GLK-IN-1 is a HPK1 and GLK inhibitor. HPK1/GLK-IN-1 (compound 38) potently inhibits GLK with an IC₅₀ of  33 nM . HPK1-IN-26 can be used for the research of animal pathogen infection .

HY-153073

TLR7 agonist 8	Toll-like Receptor (TLR) Interleukin Related	Infection Inflammation/Immunology Cancer
TLR7 agonist 8 is a TLR7 agonist with an EC₅₀ of 0.12 nM for TLR7 and an EC₅₀ of 0.76 nM for IL-6 induction. TLR7 agonist 8 can be used for research on diseases such as fibrosis, inflammatory diseases, cancer, or pathogen infections .

HY-12479

Epetraborole GSK-2251052; AN 3365	Bacterial Aminoacyl-tRNA Synthetase	Infection
Epetraborole (GSK2251052) is a leucyl-tRNA synthetase (LeuRS) inhibitor (*IC₅₀=0.31 μM), thereby inhibiting protein synthesis. Epetraborole can be used in multidrug-resistant gram-negative pathogens infection* research .**

HY-P10400A

AtPep1 TFA	Phytohormone	Infection
AtPep1 TFA is an endogenous inducer of innate immune responses. AtPep1 TFA can be isolated from Arabidopsis thaliana leaves. AtPep1 TFA activates the transcription of defensin (PDF1.2), the expression of PROPEP1, the synthesis of hydrogen peroxide (H₂O₂) near leaf veins, and the alkalization of Arabidopsis suspension cell culture medium. AtPep1 TFA induces the expression of genes encoding defensins and PR-1. AtPep1 TFA is applicable to studies related to Pythium irregulare infection and pathogen infection .

HY-12479B

Epetraborole (R-mandelate) GSK-2251052 (R-mandelate); AN 3365 (R-mandelate)	Bacterial Aminoacyl-tRNA Synthetase	Infection
Epetraborole R-mandelate is a novel leucyl-tRNA synthetase (LeuRS) inhibitor (*IC₅₀=0.31 μM), thereby inhibiting protein synthesis. Epetraborole R-mandelate can be used in multidrug-resistant gram-negative pathogens infection* research .**

HY-W718206

Cer (t18:0/26:0)	Endogenous Metabolite Interleukin Related	Infection
Cer (t18:0/26:0) is a ceramide that can be used as an active ingredient in IL-8 production promoters and neutrophil activators. Cer (t18:0/26:0) can be used for pathogen infection research .

HY-179411

Antifungal agent 139	Fungal	Infection
Antifungal agent 139 (Compound li) is an antifungal agent that exhibits antifungal activity against Colletotrichum gloeosporioides by inhibiting CgSfu1 and CgRidA. Antifungal agent 139 completely inhibits mycelial growth, spore germination, and appressorium formation, with an EC₅₀ of 18 μg/mL. Antifungal agent 139 can completely block the pathogen's infection of host plants (such as linden trees, cypress trees). Antifungal agent 139 can be used for research on anthrax .

Cat. No.	Product Name

HY-L926

Cysteine Protease Focused Covalent Library	2,113 compounds
Cysteine proteases (CPs), a key enzyme family regulating physiological metabolism and mediating pathological processes (e.g., abnormal bone resorption, tumour invasion, and pathogen infection), represent a core therapeutic target for disease intervention via the development of specific inhibitors. Currently reported CP covalent inhibitors encompass diverse structural types, including epoxides, aziridine, and activated double bonds (vinyl sulphones, α,β-unsaturated ketones), providing clear structural references for the development of novel CP covalent inhibitors. This compound library contains multiple warheads that specifically target cysteine proteases, serving as a powerful tool for the efficient discovery of novel covalent inhibitors against this enzyme family.

Cysteine Protease Focused Covalent Library

2,113 compounds

Cysteine proteases (CPs), a key enzyme family regulating physiological metabolism and mediating pathological processes (e.g., abnormal bone resorption, tumour invasion, and pathogen infection), represent a core therapeutic target for disease intervention via the development of specific inhibitors. Currently reported CP covalent inhibitors encompass diverse structural types, including epoxides, aziridine, and activated double bonds (vinyl sulphones, α,β-unsaturated ketones), providing clear structural references for the development of novel CP covalent inhibitors.

This compound library contains multiple warheads that specifically target cysteine proteases, serving as a powerful tool for the efficient discovery of novel covalent inhibitors against this enzyme family.

HY-L925

Cysteine Protease Focused Library	9,188 compounds
Cysteine proteases (CPs), a key enzyme family regulating physiological metabolism and mediating pathological processes (such as abnormal bone resorption, tumour invasion, and pathogen infection), represent a core therapeutic target for developing specific inhibitors in disease intervention. Currently reported CP inhibitors primarily achieve their inhibitory function by precisely binding to CP active pockets (e.g., S1-S4 non-primed regions or S1'-S2' primed regions) and forming covalent/non-covalent interactions with the active site cysteine residues, providing clear structural references for the development of novel inhibitors. This compound library, designed based on the core strategy of "similarity-based known active structures", contains over 200 cysteine protease inhibitors. Leveraging AI-driven molecular screening technology, it retains the critical pharmacological and shape features of reported CP inhibitors, serving as a specialized tool for efficiently discovering novel cysteine protease inhibitors.

Cysteine Protease Focused Library

9,188 compounds

Cysteine proteases (CPs), a key enzyme family regulating physiological metabolism and mediating pathological processes (such as abnormal bone resorption, tumour invasion, and pathogen infection), represent a core therapeutic target for developing specific inhibitors in disease intervention. Currently reported CP inhibitors primarily achieve their inhibitory function by precisely binding to CP active pockets (e.g., S1-S4 non-primed regions or S1'-S2' primed regions) and forming covalent/non-covalent interactions with the active site cysteine residues, providing clear structural references for the development of novel inhibitors.

This compound library, designed based on the core strategy of "similarity-based known active structures", contains over 200 cysteine protease inhibitors. Leveraging AI-driven molecular screening technology, it retains the critical pharmacological and shape features of reported CP inhibitors, serving as a specialized tool for efficiently discovering novel cysteine protease inhibitors.

Cat. No.	Product Name	Target	Research Area

HY-P10400A

AtPep1 TFA	Phytohormone	Infection
AtPep1 TFA is an endogenous inducer of innate immune responses. AtPep1 TFA can be isolated from Arabidopsis thaliana leaves. AtPep1 TFA activates the transcription of defensin (PDF1.2), the expression of PROPEP1, the synthesis of hydrogen peroxide (H₂O₂) near leaf veins, and the alkalization of Arabidopsis suspension cell culture medium. AtPep1 TFA induces the expression of genes encoding defensins and PR-1. AtPep1 TFA is applicable to studies related to Pythium irregulare infection and pathogen infection .

Coronatine	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Disease Research Fields Source Classification Agricultural Research	Bacterial Phytohormone
Coronatine is a plant growth regulator that mimicks the jasmonic acid-isoleucine conjugate (JA-Ile), targets the jasmonic acid receptor COI1, activates the jasmonic acid signaling pathway, thereby inhibiting salicylic acid (SA)-dependent defense responses. Coronatine antagonizes the stomatal closure, induces plant cell necrosis and chlorosis, interfers with plant hormone balance, thereby promoting pathogen infection .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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