AtPep1 TFA 

AtPep1 TFA is an endogenous inducer of innate immune responses. AtPep1 TFA can be isolated from Arabidopsis thaliana leaves. AtPep1 TFA activates the transcription of defensin (PDF1.2), the expression of PROPEP1, the synthesis of hydrogen peroxide (H₂O₂) near leaf veins, and the alkalization of Arabidopsis suspension cell culture medium. AtPep1 TFA induces the expression of genes encoding defensins and PR-1. AtPep1 TFA is applicable to studies related to Pythium irregulare infection and pathogen infection^[1][2].

AtPep1 TFA (20 min) induces medium alkalization in suspension-cultured Arabidopsis thaliana cells, with a half-maximal activity of approximately 0.25 nM^[1].
AtPep1 (TFA) (10 nM; 2 h) induces the expression of PROPEP1 and PDF1.2 genes in detached leaves of *Arabidopsis thaliana* (Columbia ecotype). This response depends on functional jasmonic acid and ethylene pathways, and is partially dependent on NADPH oxidase activity^[1].
AtPep1 (TFA) (10 nM; 2 h) induces vein-associated H₂O₂ accumulation in detached leaves of *Arabidopsis thaliana* (Columbia ecotype)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2491.81 (free base)

C₁₀₄H₁₈₃N₃₉O₃₂·xC₂HF₃O₂

Solid

White to off-white

Ala-Thr-Lys-Val-Lys-Ala-Lys-Gln-Arg-Gly-Lys-Glu-Lys-Val-Ser-Ser-Gly-Arg-Pro-Gly-Gln-His-Asn

ATKVKAKQRGKEKVSSGRPGQHN

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Huffaker A, et al. An endogenous peptide signal in Arabidopsis activates components of the innate immune response. Proc Natl Acad Sci U S A. 2006;103(26):10098-10103.  [Content Brief]

  [2]. Pearce G, et al. Structure-activity studies of AtPep1, a plant peptide signal involved in the innate immune response. Peptides. 2008;29(12):2083-2089.