Gibberellins

Gibberellins (GAs) are diterpene phytohormones that modulate plant growth, development, and life-cycle progression across flowering plants^[1]. Mechanistically, bioactive GA binds GIBBERELLIN INSENSITIVE DWARF1 (GID1) and de-represses GA signaling by promoting DELLA degradation through the ubiquitin-proteasome pathway^[1]^[2]. Because DELLA proteins act as master growth repressors and signaling hubs, the GA-GID1-DELLA module connects endogenous developmental programs with environmental cues that regulate GA metabolism, GA content, and DELLA levels^[1]. In immune-related experimental models, DELLA stabilization contributes to flg22-induced growth inhibition and alters salicylic acid and jasmonic acid signaling, thereby changing resistance to necrotrophic and biotrophic pathogens in Arabidopsis^[3]. Compared with related GA receptor isoforms, GID1a has a primary role in stem elongation and fertility, whereas GID1b contributes more strongly than GID1c to non-proteolytic GA signaling because it shows higher affinity for GA and DELLA proteins^[4]. For experimental applications, GA biosynthesis inhibitors and growth retardants such as uniconazole-P reduce shoot growth by inhibiting GA biosynthesis, but uniconazole-P also strongly inhibits ABA catabolism, so inhibitor-based GA studies should control for ABA-related effects^[5].

References:

[1]. Sun TP. The molecular mechanism and evolution of the GA-GID1-DELLA signaling module in plants. Curr Biol. 2011 May 10;21(9):R338-45. doi: 10.1016/j.cub.2011.02.036. PMID: 21549956. et al. The molecular mechanism and evolution of the GA-GID1-DELLA signaling module in plants. Curr Biol. 2011 May 10;21(9):R338-45. [Content Brief]

[2]. Hirano K, et al. GID1-mediated gibberellin signaling in plants. Trends Plant Sci. 2008 Apr;13(4):192-9. [Content Brief]

[3]. Navarro L, et al. DELLAs control plant immune responses by modulating the balance of jasmonic acid and salicylic acid signaling. Curr Biol. 2008 May 6;18(9):650-5. [Content Brief]

[4]. Hauvermale AL, et al. The roles of the GA receptors GID1a, GID1b, and GID1c in sly1-independent GA signaling. Plant Signal Behav. 2014;9(2):e28030. [Content Brief]

[5]. Saito S, et al. A plant growth retardant, uniconazole, is a potent inhibitor of ABA catabolism in Arabidopsis. Biosci Biotechnol Biochem. 2006 Jul;70(7):1731-9. [Content Brief]

Gibberellins Inhibitor (1)

Gibberellins Related Products (1):

Cat. No.	Product Name	Effect	Purity

HY-N15579

Fujenal	Inhibitor
Fujenal is a kaurene-type diterpenoid found in Gibberella fujikuroi. Fujenal shows moderate inhibition against HeLa tumor cells and acts as a gibberellin biosynthesis inhibitor. Fujenal is promising for research of plant growth regulators and antitumor agents.

Name
Email *

	Sorry, but the email address you supplied was invalid.