Brassinolide

Brassinolide is a plant growth-promoting steroid isolated from Brassica napus pollen and functions as the most active brassinosteroid in plant growth regulation^[1]^[2]. Mechanistically, brassinolide acts through the plasma-membrane receptor BRI1, which binds brassinolide through its extracellular domain and initiates brassinosteroid signaling^[3]^[4]. BRI1 associates with BAK1, and the BRI1/BAK1 receptor kinase pair activates downstream phosphorylation events that regulate BIN2, BZR1, and BES1 transcriptional control^[5]^[6]. In plant models, this pathway supports cell elongation, development, stress responses, and experimental analysis of brassinosteroid-dependent phenotypes^[6]^[7]. Compared with related receptor isoforms, BRL1 recognizes brassinolide through a conserved binding site, but subtle structural differences generate differential brassinolide recognition within the BRI1 receptor family^[8]. For research applications, brassinolide serves as an active pathway agonist, whereas brassinazole provides a triazole-type brassinosteroid biosynthesis inhibitor for dissecting brassinosteroid function in plants^[9].

References:

[1]. Kiros M, et al. Trends in HIV-1 pretreatment drug resistance and HIV-1 variant dynamics among antiretroviral therapy-naive Ethiopians from 2003 to 2018: a pooled sequence analysis. Virol J. 2023 Oct 25;20(1):243. [Content Brief]

[2]. Wang ZY, et al. BRI1 is a critical component of a plasma-membrane receptor for plant steroids. Nature. 2001 Mar 15;410(6826):380-3. [Content Brief]

[3]. Kinoshita T, et al. Binding of brassinosteroids to the extracellular domain of plant receptor kinase BRI1. Nature. 2005 Jan 13;433(7022):167-71. [Content Brief]

[4]. She J, et al. Structural insight into brassinosteroid perception by BRI1. Nature. 2011 Jun 12;474(7352):472-6. [Content Brief]

[5]. Nam KH, et al. BRI1/BAK1, a receptor kinase pair mediating brassinosteroid signaling. Cell. 2002 Jul 26;110(2):203-12. [Content Brief]

[6]. Wang ZY, et al. The brassinosteroid signal transduction pathway. Cell Res. 2006 May;16(5):427-34. [Content Brief]

[7]. Nolan TM, et al. Brassinosteroids: Multidimensional Regulators of Plant Growth, Development, and Stress Responses. Plant Cell. 2020 Feb;32(2):295-318. [Content Brief]

[8]. She J, et al. Structural basis for differential recognition of brassinolide by its receptors. Protein Cell. 2013 Jun;4(6):475-82. [Content Brief]

[9]. Asami T, et al. Characterization of brassinazole, a triazole-type brassinosteroid biosynthesis inhibitor. Plant Physiol. 2000 May;123(1):93-100. [Content Brief]

Brassinolide Related Products (1):

Cat. No.	Product Name	Effect	Purity

HY-19699

1-Naphthylacetamide
1-Naphthylacetamide is an orally active nonsteroidal anti-inflammatory agent (NAIA) and also an indole-type auxin plant growth regulator. 1-Naphthylacetamide inhibits inflammatory response-related pathways and modulates plant hormone signaling, exhibiting anti-inflammatory, local anesthetic, antispasmodic, analgesic, and diuretic activities. 1-Naphthylacetamide promotes plant cell expansion, differentiation, and fruit enlargement. Additionally, 1-Naphthylacetamide induces central nervous system (CNS) depression in mice, characterized by reduced spontaneous activity, decreased irritability, decreased muscle tone, and attenuated ear-cuff reflex, ipsilateral flexor reflex, and corneal reflex^[1][2].

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