TLR7 agonist 8

Cat. No.: HY-153073: Data Sheet Handling Instructions
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TLR7 agonist 8 is a TLR7 agonist with an EC₅₀ of 0.12 nM for TLR7 and an EC₅₀ of 0.76 nM for IL-6 induction. TLR7 agonist 8 can be used for research on diseases such as fibrosis, inflammatory diseases, cancer, or pathogen infections.

For research use only. We do not sell to patients.

TLR7 agonist 8 Chemical Structure

CAS No. : 2380231-81-0

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View All Isoforms

TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

View All Interleukin Related Isoform Specific Products:

View All Isoforms

IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

TLR7

0.12 nM (EC₅₀)

IL-6

0.76 nM (EC₅₀)

In Vitro

TLR7 agonist 8 (Compound IIb-34) potently activates TLR7 in HEK Blue cells with an EC₅₀ of 0.12 nM^[1].
TLR7 agonist 8 potently induces IL-6 with an EC₅₀ of 0.76 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

512.60

Formula

C₂₉H₃₂N₆O₃

CAS No.

2380231-81-0

SMILES

OC(N1C2=NC(OCC/C=C\CC3=CC(C1)=CC=C3C4=CC=C(C=C4)CNC5CCOCC5)=N6)=NC2=C6N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Purandare AV, et al. Macrocyclic toll-like receptor 7 (tlr7) agonists. United States, WO2019209811 A. 2019-10-31.

TLR7 agonist 8 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TLR7 agonist 82380231-81-0Toll-like Receptor (TLR)Interleukin RelatedILTLR7Toll-like receptor 7HEK Blue cellsinterleukin 6Inhibitorinhibitorinhibit

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