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Results for "

phenylketonuria

" in MedChemExpress (MCE) Product Catalog:

標的別:	Amino acid Transporter (6) Bacterial (1) Biochemical Assay Reagents (2) CD38 (1) Drug Metabolite (2) Endogenous Metabolite (8) Endothelin Receptor (1) Fungal (5) Isotope-Labeled Compounds (2) Reference Standards (3)
研究分野別:	Cancer (1) Cardiovascular Disease (1) Infection (8) Inflammation/Immunology (3) Metabolic Disease (17)

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製品番号	製品名	Target	研究分野	構造式

HY-A0124A

Sapropterin dihydrochloride 2 Publications Verification (6R)-BH4 dihydrochloride; (6R)-Tetrahydro-L-biopterin dihydrochloride	Endogenous Metabolite	Infection Metabolic Disease Inflammation/Immunology
Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) dihydrochloride is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin dihydrochloride can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin dihydrochloride can aggravate experimental autoimmune encephalomyelitis (EAE) .

HY-156682

JNT-517	Amino acid Transporter	Metabolic Disease
JNT-517 is an orally active, selective SLC6A19 allosteric inhibitor with an IC₅₀ of 47 nM for human SLC6A19. JNT-517 can be used for the study of phenylketonuria (PKU) .

HY-30220

(S)-2-Hydroxy-3-phenylpropanoic acid L-(-)-3-Phenyllactic Acid	Endogenous Metabolite Fungal	Infection Metabolic Disease
(S)-2-Hydroxy-3-phenylpropanoic acid is the L-configuration of 2-Hydroxy-3-phenylpropanoic acid, and its level is closely related to some diseases, such as phenylketonuria .

HY-W015590

2-Hydroxyphenylacetic acid	Drug Metabolite Fungal	Infection Metabolic Disease
2-Hydroxyphenylacetic acid is a metabolite of Phenylalanine and Tyrosine, as well as a product of the biotransformation of Phenylacetonitrile by marine fungi. 2-Hydroxyphenylacetic acid acts as a potential biomarker for food. 2-Hydroxyphenylacetic acid slightly induces the expression of green fluorescent protein. 2-Hydroxyphenylacetic acid is used in the research of phenylketonuria and related hyperphenylalaninemia .

HY-A0124

Sapropterin (6R)-BH4; (6R)-Tetrahydro-L-biopterin	Endogenous Metabolite	Infection Metabolic Disease Inflammation/Immunology
Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin can aggravate experimental autoimmune encephalomyelitis (EAE) .

HY-A0124AR

Sapropterin dihydrochloride (Standard) (6R)-BH4 dihydrochloride (Standard); (6R)-Tetrahydro-L-biopterin dihydrochloride (Standard)	Endogenous Metabolite Reference Standards	Infection Metabolic Disease Inflammation/Immunology
Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) dihydrochloride (Standard) is the analytical standard of Sapropterin dihydrochloride (HY-A0124A) . This product is intended for research and analytical applications. Sapropterin dihydrochloride is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin dihydrochloride can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin dihydrochloride can aggravate experimental autoimmune encephalomyelitis (EAE) .

HY-162864

JX237	Amino acid Transporter	Metabolic Disease
JX237 is an inhibitor of the epithelial neutral amino acid transporter B ⁰AT1 (SLC6A19) with an IC₅₀ value of 31 nM. SLC6A19 is the main transporter for the absorption of neutral amino acids in the intestines and their reabsorption in the kidneys. By inhibiting B ⁰AT1, JX237 can be used for the study of disorders of amino acid metabolism .

HY-158161

SLC6A19-IN-1	Amino acid Transporter	Metabolic Disease
SLC6A19-IN-1 is a potent and highly selective inhibitor and transport corrector of human SLC6A19 (IC₅₀=47 nM). Furthermore, at a concentration of 35 μM, SLC6A19-IN-1 exhibits no activity against SLC1A5, SLC7A5, or SLC6A8. SLC6A19-IN-1 is applicable to research on phenylketonuria (PKU) and hyperphenylalaninemia. SLC6A19-IN-1 is also suitable for studies related to various metabolic disorders, including tyrosinemia, maple syrup urine disease, urea cycle disorders, and hyperammonemia .

HY-P2964

Phenylalanine dehydrogenase	Endogenous Metabolite	Metabolic Disease
Phenylalanine dehydrogenase is an NAD ⁺-dependent oxidoreductase targeting L-phenylalanine. Phenylalanine dehydrogenase catalyzes deamination to phenylpyruvate and NADH as part of amino acid metabolism regulation. Phenylalanine dehydrogenase is promising for research of phenylketonuria (PKU) .

HY-P10563

Noraramtide BHV-1100	CD38	Cancer
Noraramtide (BHV-1100) is an antibody recruitment molecule. Noraramtide can specifically bind to CD38 molecules to recruit natural killer (NK) cells. Noraramtide enhances the ability of NK cells to kill tumor cells through antibody-dependent cellular cytotoxicity (ADCC). This mechanism allows NK cells to more effectively recognize and eliminate tumor cells while avoiding mutual killing between NK cells. Noraramtide can be used for the study of autologous cancer immunity .

HY-144856S1

Sapropterin-d3 (6R)-BH4-d₃; (6R)-Tetrahydro-L-biopterin-d₃	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Sapropterin-d₃ ((6R)-BH4-d₃) is deuterium labeled Sapropterin. Sapropterin ((6R)-BH4) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU) .

HY-P3350

LS-BF1	Bacterial	Infection
LS-BF1 is a stable and low toxic cationic antimicrobial peptide. LS-BF1 displays broad spectrum of antibacterial activity, including the challenging ESKAPE pathogens, by cell membrane disruptive mechanism. LS-BF1 shows good in vivo efficacy for elimination of bacteria in a mouse infection model[1].

HY-179107

SLC6A19-IN-3	Amino acid Transporter	Metabolic Disease
SLC6A19-IN-3 (Compound 83-P1-P2) is a potent, selective and orally active SLC6A19 inhibitor with an IC₅₀ of 28 nM. SLC6A19-IN-3 can block SLC6A19-mediated transmembrane transport of phenylalanine, reducing intestinal absorption of phenylalanine from food and renal tubular reabsorption of phenylalanine. SLC6A19-IN-3 can be used for the research of metabolic disease, such as phenylketonuria .

HY-P2951

Phenylalanine ammonia-lyase	Biochemical Assay Reagents	Metabolic Disease
Phenylalanine ammonia-lyase is a non-mammalian enzyme converting phenylalanine into trans-cinnamic acid and ammonia. Phenylalanine ammonia-lyase can be used in the research of phenylketonuria .

HY-176873

SLC6A19-IN-2	Amino acid Transporter	Metabolic Disease
SLC6A19-IN-2 (Example 4) is a potent SLC6A19 inhibitor with an IC₅₀ of 14 nM. SLC6A19-IN-2 can be used for the study of metabolic diseases such as nonalcoholic steatohepatitis (NASH), nonalcoholic fatty liver disease (NAFLD) and phenylketonuria (PKU) .

HY-105168

TAK 044	Endothelin Receptor	Cardiovascular Disease
TAK 044 is an antagonist of Endothelin Receptor. TAK 044 strongly inhibits ET-induced deterioration in various animal models. TAK 044 can be used in study ET-related diseases such as acute myocardial infarction,acute renal failure, acute hepatic malfunction, and subarachnoid hemorrhage .

HY-W015590R

2-Hydroxyphenylacetic acid (Standard)	Reference Standards Drug Metabolite Fungal	Infection Metabolic Disease
2-Hydroxyphenylacetic acid (Standard) is an analytical standard for 2-Hydroxyphenylacetic acid (HY-W015590). This product is intended for research and analytical applications. 2-Hydroxyphenylacetic acid is a metabolite of Phenylalanine and Tyrosine, and is also a product of the biotransformation of Phenylacetonitrile by marine fungi. 2-Hydroxyphenylacetic acid can be used as a potential biomarker for food. 2-Hydroxyphenylacetic acid can be used in the study of phenylketonuria and related hyperphenylalaninemias .

HY-30220R

(S)-2-Hydroxy-3-phenylpropanoic acid (Standard) L-(-)-3-Phenyllactic Acid (Standard)	Endogenous Metabolite Fungal Reference Standards	Infection Metabolic Disease
(S)-2-Hydroxy-3-phenylpropanoic acid (Standard) is the analytical standard of (S)-2-Hydroxy-3-phenylpropanoic acid. This product is intended for research and analytical applications. (S)-2-Hydroxy-3-phenylpropanoic acid is the L-configuration of 2-Hydroxy-3-phenylpropanoic acid, and its level is closely related to some diseases, such as phenylketonuria .

HY-W753181

(S)-2-Hydroxy-3-phenylpropanoic acid-13C9 L-(-)-3-Phenyllactic Acid-¹³C₉	Isotope-Labeled Compounds Fungal Endogenous Metabolite	Metabolic Disease
(S)-2-Hydroxy-3-phenylpropanoic acid- ¹³C₉ (L-(-)-3-Phenyllactic Acid- ¹³C₉) is the ¹³C-labeled (S)-2-Hydroxy-3-phenylpropanoic acid (HY-30220). (S)-2-Hydroxy-3-phenylpropanoic acid is the L-configuration of 2-Hydroxy-3-phenylpropanoic acid, and its level is closely related to some diseases, such as phenylketonuria .

HY-179581

SLC6A19-IN-4	Amino acid Transporter	Metabolic Disease
SLC6A19-IN-4 is an allosteric-competitive and orally active B ⁰AT1 inhibitor. SLC6A19-IN-4 inhibits both human and mouse B ⁰AT1 with IC₅₀ values of 513 nM and 295 nM, respectively. SLC6A19-IN-4 exhibits excellent metabolic stability. SLC6A19-IN-4 significantly increases urinary phenylalanine (Phe) excretion and reduces plasma Phe levels through dual inhibition of B ⁰AT1 in both the intestine (reducing absorption) and kidney (promoting excretion) in vivo. SLC6A19-IN-4 can be used for phenylketonuria (PKU) and other disorders involving SLC6-family transporters research .

HY-P4948

Coumarin-Phalloidin	Biochemical Assay Reagents	Others
Coumarin-phalloidin is a kind of phalloidin labeled with Coumarin (HY-N0709). Coumarin-phalloidin is a new type of actin probe that can be used for triple immunofluorescence microscopic observation of the cell skeleton .

製品番号	製品名

HY-L189

Amino Acid Metabolism Compound Library	335 compounds
Amino acids, as one of the most fundamental organic compounds in living organisms, serve not only as the basic building blocks of proteins but also but also undertake the functions of energy supply, neurotransmitter synthesis, and maintenance of internal environment stability.Amino acid metabolic enzymes are a class of enzymes involved in the metabolic processes of amino acids, catalyzing their synthesis, breakdown, transformation, and interactions with other metabolic pathways. Abnormalities in amino acid metabolic enzymes can lead to various metabolic diseases, such as phenylketonuria and hyperammonemia, etc. Therefore, actively exploring and regulating the processes of amino acid metabolism is crucial for the development of drugs related to these diseases. MCE designs a unique collection of 335 small molecules target amino acid metabolizing enzymes, which is an important tool for studying studying amino acid metabolism processes or metabolism-related drug development.

Amino Acid Metabolism Compound Library

335 compounds

Amino acids, as one of the most fundamental organic compounds in living organisms, serve not only as the basic building blocks of proteins but also but also undertake the functions of energy supply, neurotransmitter synthesis, and maintenance of internal environment stability.Amino acid metabolic enzymes are a class of enzymes involved in the metabolic processes of amino acids, catalyzing their synthesis, breakdown, transformation, and interactions with other metabolic pathways. Abnormalities in amino acid metabolic enzymes can lead to various metabolic diseases, such as phenylketonuria and hyperammonemia, etc. Therefore, actively exploring and regulating the processes of amino acid metabolism is crucial for the development of drugs related to these diseases.

MCE designs a unique collection of 335 small molecules target amino acid metabolizing enzymes, which is an important tool for studying studying amino acid metabolism processes or metabolism-related drug development.

製品番号	製品名	Target	研究分野