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Cat. No.: HY-158161

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SLC6A19-IN-1

SLC6A19-IN-1 is a potent and highly selective inhibitor and transport corrector of human SLC6A19 (IC₅₀=47 nM). Furthermore, at a concentration of 35 μM, SLC6A19-IN-1 exhibits no activity against SLC1A5, SLC7A5, or SLC6A8. SLC6A19-IN-1 is applicable to research on phenylketonuria (PKU) and hyperphenylalaninemia. SLC6A19-IN-1 is also suitable for studies related to various metabolic disorders, including tyrosinemia, maple syrup urine disease, urea cycle disorders, and hyperammonemia.

For research use only. We do not sell to patients.

CAS No.: 3032920-98-9
Formula: C₂₀H₂₁F₃N₆O₂
Molecular Weight:434.41

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

SLC6A19-IN-1 Chemical Structure

CAS No.: 3032920-98-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

SLC6A19^[1]

In Vitro

SLC6A19-IN-1 (compound 16) blocks SLC6A19, thereby reducing intestinal absorption and renal reabsorption of phenylalanine, and lowering phenylalanine levels in the blood. Moreover, the high selectivity of SLC6A19-IN-1 greatly reduces the risk of side effects caused by off-target effects, such as avoiding interference with cell growth (SLC1A5 / SLC7A5) or impairment of brain function (SLC6A8)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3032920-98-9
Molecular Weight 434.41
Formula C₂₀H₂₁F₃N₆O₂
SMILES

O=C(NCCC1(CC1)N)N2C[C@](C3=NC(C4=CC=C(C=C4)C#N)=NO3)(CC2)C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wobst HJ, et al. SLC6A19 inhibition facilitates urinary neutral amino acid excretion and lowers plasma phenylalanine. JCI Insight. 2024;9(21):e182876. Published 2024 Nov 8. [Content Brief]

[2]. Ryan HA, et al. Treating pku with correctors of mammalian slc6a19 function. WO2024059005A1. 2023-09-11.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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