JN-170
JN-170 is a potent and highly selective inhibitor and transport corrector of human SLC6A19 (IC50=47 nM). Furthermore, at a concentration of 35 μM, JN-170 exhibits no activity against SLC1A5, SLC7A5, or SLC6A8. JN-170 is applicable to research on phenylketonuria (PKU) and hyperphenylalaninemia. JN-170 is also suitable for studies related to various metabolic disorders, including tyrosinemia, maple syrup urine disease, urea cycle disorders, and hyperammonemia.
For research use only. We do not sell to patients.
- CAS No.: 3032920-98-9
- Formula: C20H21F3N6O2
- Molecular Weight:434.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
SLC6A19[1]
In Vitro
JN-170 (compound 16) blocks SLC6A19, thereby reducing intestinal absorption and renal reabsorption of phenylalanine, and lowering phenylalanine levels in the blood. Moreover, the high selectivity of JN-170 greatly reduces the risk of side effects caused by off-target effects, such as avoiding interference with cell growth (SLC1A5 / SLC7A5) or impairment of brain function (SLC6A8)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 3032920-98-9
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Molecular Weight 434.41
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Formula C20H21F3N6O2
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SMILES
O=C(NCCC1(CC1)N)N2C[C@](C3=NC(C4=CC=C(C=C4)C#N)=NO3)(CC2)C(F)(F)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JN-170 Related Classifications
HY-158161 Related Classifications
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