JN-170
JN-170 is a potent and highly selective inhibitor and transport corrector of human SLC6A19 (IC50=47 nM). Furthermore, at a concentration of 35 μM, JN-170 exhibits no activity against SLC1A5, SLC7A5, or SLC6A8. JN-170 is applicable to research on phenylketonuria (PKU) and hyperphenylalaninemia. JN-170 is also suitable for studies related to various metabolic disorders, including tyrosinemia, maple syrup urine disease, urea cycle disorders, and hyperammonemia.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 3032920-98-9
- 分子式: C20H21F3N6O2
- 分子量:434.41
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
SLC6A19[1]
JN-170 (compound 16) blocks SLC6A19, thereby reducing intestinal absorption and renal reabsorption of phenylalanine, and lowering phenylalanine levels in the blood. Moreover, the high selectivity of JN-170 greatly reduces the risk of side effects caused by off-target effects, such as avoiding interference with cell growth (SLC1A5 / SLC7A5) or impairment of brain function (SLC6A8)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 3032920-98-9
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分子量 434.41
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分子式 C20H21F3N6O2
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SMILES
O=C(NCCC1(CC1)N)N2C[C@](C3=NC(C4=CC=C(C=C4)C#N)=NO3)(CC2)C(F)(F)F
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
JN-170 関連分類
HY-158161 関連分類
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