Sapropterin
Based on 3 publication(s) in Google Scholar
Sapropterin Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) is an orally active cofactor of phenylalanine hydroxylase (PAH) that effectively reduces blood phenylalanine concentrations. Sapropterin can be used in research on phenylketonuria (PKU). Sapropterin can aggravate experimental autoimmune encephalomyelitis (EAE).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 62989-33-7
- Formel: C9H15N5O3
- Molecular Weight:241.25
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Sapropterin
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Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
PAH |
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SJL/J (female, 10-12-week-old, primary progressive and PLP-induced-relapsing-remitting EAE)[2]
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Dosage:100 mg/kg/day
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Administration:oral; daily; 22 days
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Result:Reached higher maximum clinical EAE scores and showed a significant increase in the area under the curve (AUC) of EAE scores.
Elevated plasma levels of long-chain ceramides (C14Cer, C16Cer, C18Cer, C20Cer, C18GluCer, C24:1GluCer).
Reduced plasma linolenic acid (FA18:3) levels and increased plasma levels of the endocannabinoid 1+2AG.
Showed no significant effect on peripheral T-cell proliferation or subpopulations in the spleen, but increased infiltration of CD4+ and CD8+ T-cells in the spinal cord.
Chemical Information
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CAS. Nr. 62989-33-7
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Molecular Weight 241.25
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Formel C9H15N5O3
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SMILES
O=C1C2=C(NC(N)=N1)NC[C@](N2)([H])[C@@H](O)[C@@H](O)C
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Synonyms
(6R)-BH4; (6R)-Tetrahydro-L-biopterin
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (3)
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Journal Impact Factor
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Most Recent
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Mol Cell
PTPS Facilitates Compartmentalized LTBP1 S-Nitrosylation and Promotes Tumor Growth under Hypoxia. [Abstract]2020 Jan 2;77(1):95-107.e5. PMID: 31628042 -
Immunol Invest
2025 Nov;54(8):1542-1560. PMID: 41031680 -
Reinheit & Dokumentation
Verweise
[1]. Levy H L, et al. Efficacy of sapropterin dihydrochloride (tetrahydrobiopterin, 6R-BH4) for reduction of phenylalanine concentration in patients with phenylketonuria: a phase III randomised placebo-controlled study[J]. The Lancet, 2007, 370(9586): 504-510. [Content Brief]
[2]. Schmitz K, et al. Sapropterin (BH4) Aggravates Autoimmune Encephalomyelitis in Mice. Neurotherapeutics. 2021;18(3):1862-1879. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Sapropterin Related Classifications
HY-A0124 Related Classifications
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