1. Alkaloid

Sapropterin dihydrochloride (Synonyms: 6R-BH4 dihydrochloride; 6R-Tetrahydro-L-biopterin dihydrochloride)

Cat. No.: HY-A0124A Purity: 99.97%
Handling Instructions

Sapropterin dihydrochloride is a synthetic form of BH4 that is approved for the treatment of BH4 responsive PKU.

For research use only. We do not sell to patients.

Sapropterin dihydrochloride Chemical Structure

Sapropterin dihydrochloride Chemical Structure

CAS No. : 69056-38-8

Size Price Stock Quantity
10 mM * 1 mL in Water USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 96 In-stock
Estimated Time of Arrival: December 31
100 mg USD 168 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Sapropterin dihydrochloride is a synthetic form of BH4 that is approved for the treatment of BH4 responsive PKU. (1) Sapropterin dihydrochloride can stimulate TH and TPH activities leading to improved dopamine and serotonin synthesis despite persistently elevated brain phenylalanine. (2) Sapropterin dihydrochloride is used to lower blood phenylalanine levels in tetrahydrobiopterin-responsive phenylketonuria in conjunction with a phenylalanine-restricted diet.

Clinical Trial
Solvent & Solubility
In Vitro: 

H2O : ≥ 34 mg/mL (108.22 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1830 mL 15.9150 mL 31.8299 mL
5 mM 0.6366 mL 3.1830 mL 6.3660 mL
10 mM 0.3183 mL 1.5915 mL 3.1830 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

314.17

Formula

C₉H₁₇Cl₂N₅O₃

CAS No.

69056-38-8

SMILES

O=C1N=C(N)NC2=C1N[[email protected]@H]([[email protected]@H](O)[[email protected]@H](O)C)CN2.[H]Cl.[H]Cl

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.97%

  • Molarity Calculator

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Sapropterin dihydrochloride
Cat. No.:
HY-A0124A
Quantity:

Sapropterin dihydrochloride

Cat. No.: HY-A0124A