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  5. Sapropterin dihydrochloride

Sapropterin dihydrochloride  (Synonyms: (6R)-BH4 dihydrochloride; (6R)-Tetrahydro-L-biopterin dihydrochloride)

Cat. No.: HY-A0124A Purity: 99.82%
COA Handling Instructions

Sapropterin ((6R)-BH4) dihydrochloride is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin dihydrochloride can be used in study of phenylketonuria (PKU).

For research use only. We do not sell to patients.

Sapropterin dihydrochloride Chemical Structure

Sapropterin dihydrochloride Chemical Structure

CAS No. : 69056-38-8

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Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 66 In-stock
Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Solid
5 mg USD 38 In-stock
10 mg USD 60 In-stock
50 mg USD 96 In-stock
100 mg USD 168 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Sapropterin dihydrochloride:

Sapropterin dihydrochloride Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Sapropterin dihydrochloride

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Description

Sapropterin ((6R)-BH4) dihydrochloride is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin dihydrochloride can be used in study of phenylketonuria (PKU)[1].

Clinical Trial
Molecular Weight

314.17

Appearance

Solid

Formula

C9H17Cl2N5O3
CAS No.
SMILES

O=C1N=C(N)NC2=C1N[C@@H]([C@@H](O)[C@@H](O)C)CN2.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 200 mg/mL (636.60 mM)

H2O : 100 mg/mL (318.30 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1830 mL 15.9150 mL 31.8299 mL
5 mM 0.6366 mL 3.1830 mL 6.3660 mL
10 mM 0.3183 mL 1.5915 mL 3.1830 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (318.30 mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.82%

COA (251 KB) HNMR (255 KB) LCMS (265 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Sapropterin69056-38-8(6R)-BH4(6R)-Tetrahydro-L-biopterinOthersPKUPAHphenylalanine hydroxylaseInhibitorinhibitorinhibit

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