JX237
Based on 1 Customer Validation
JX237 is an inhibitor of the epithelial neutral amino acid transporter B0AT1 (SLC6A19) with an IC50 value of 31 nM. SLC6A19 is the main transporter for the absorption of neutral amino acids in the intestines and their reabsorption in the kidneys. By inhibiting B0AT1, JX237 can be used for the study of disorders of amino acid metabolism.
For research use only. We do not sell to patients.
- Purity: 98.84%
- CAS No.: 1021125-90-5
- Formula: C11H15BrN2O
- Molecular Weight:271.15
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
JX237 inhibits B0AT1 (SLC6A19) with an IC50 of 280 nM in radioactive L-leucine uptake assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1021125-90-5
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Appearance Solid
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Molecular Weight 271.15
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Formula C11H15BrN2O
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Color Yellow to brown
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SMILES
BrC1=C(C)C=C(NCC(NCC)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 250 mg/mL (922.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6880 mL | 18.4400 mL | 36.8800 mL | 92.1999 mL |
| 5 mM | 0.7376 mL | 3.6880 mL | 7.3760 mL | 18.4400 mL | |
| 10 mM | 0.3688 mL | 1.8440 mL | 3.6880 mL | 9.2200 mL | |
| 15 mM | 0.2459 mL | 1.2293 mL | 2.4587 mL | 6.1467 mL | |
| 20 mM | 0.1844 mL | 0.9220 mL | 1.8440 mL | 4.6100 mL | |
| 25 mM | 0.1475 mL | 0.7376 mL | 1.4752 mL | 3.6880 mL | |
| 30 mM | 0.1229 mL | 0.6147 mL | 1.2293 mL | 3.0733 mL | |
| 40 mM | 0.0922 mL | 0.4610 mL | 0.9220 mL | 2.3050 mL | |
| 50 mM | 0.0738 mL | 0.3688 mL | 0.7376 mL | 1.8440 mL | |
| 60 mM | 0.0615 mL | 0.3073 mL | 0.6147 mL | 1.5367 mL | |
| 80 mM | 0.0461 mL | 0.2305 mL | 0.4610 mL | 1.1525 mL | |
| 100 mM | 0.0369 mL | 0.1844 mL | 0.3688 mL | 0.9220 mL |
JX237 Related Classifications
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