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phosphatidylinositol 3,4,5-trisphosphate

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By Targets:	Biochemical Assay Reagents (1) Drug Derivative (1) Endogenous Metabolite (1) Isotope-Labeled Compounds (1) Phospholipase (1) PI3K (2) PKC (1) Reference Standards (1)
By Research Areas:	Cancer (3) Inflammation/Immunology (1)

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Isotope-Labeled Compounds

Antibodies

Targets Recommended: PI4K PIKfyve PI4P5K

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103224

PIT-1	PI3K	Cancer
PIT-1 is a selective PIP3 (phosphatidylinositol 3,4,5-trisphosphate) antagonist. PIT-1 inhibits cancer cell survival and induces apoptosis by inhibition of PIP3 dependent PI3K / Akt signaling. PIT-1 exhibits antitumor activity in vivo .

HY-114457

Phosphatidylinositol 4,5-bisphosphate L-alpha-phosphatidylinositol-4,5-bisphosphate; (PtdIns)-(4,5)-P2	Phospholipase	Inflammation/Immunology
Phosphatidylinositol 4,5-bisphosphate (L-alpha-Phosphatidylinositol-4,5-bisphosphate) is a plasma membrane lipid that is enriched in the cytoplasmic leaflet of the plasma membrane. Phosphatidylinositol 4,5-bisphosphate serves as a substrate for phospholipase C and class I PI3K, generating diacylglycerol, inositol (1,4,5)-trisphosphate, and phosphatidylinositol (3,4,5)-trisphosphate. Phosphatidylinositol 4,5-bisphosphate contributes to lamellipodial protrusion, directional cell migration, focal adhesion lipid generation, and trafficking of the GABA_A receptor. Phosphatidylinositol 4,5-bisphosphate can be used in research related to acute lung injury and pulmonary edema .

HY-148971A

PtdIns-(345)-P3 (12-dipalmitoyl) sodium phosphatidylinositol tris-3,4,5-phosphate, 1,2-dipalmitoyl sodium	Drug Derivative	Others
PtdIns-(345)-P3 (12-dipalmitoyl) sodium (Phosphatidylinositol tris-3,4,5-phosphate, 1,2-dipalmitoyl sodium) is a phosphatidylinositol 3,4,5-trisphosphate (PIP3) analog. PtdIns-(345)-P3 (12-dipalmitoyl) sodium can be incorporated in liposomes establish a backdrop of membrane phospholipids that closely mirrors in vivo conditions .

HY-146946S

*D-Myo-phosphatidylinositol* 3,4,5-trisphosphate diC16-d5**	Isotope-Labeled Compounds	Others
D-Myo-phosphatidylinositol 3,4,5-trisphosphate diC16-d₅ is deuterium labeled D-Myo-phosphatidylinositol 3,4,5-trisphosphate diC16.

HY-W127317

Inositol 1,3,4,5-tetraphosphate	Biochemical Assay Reagents	Others
Inositol 1,3,4,5-tetraphosphate is the head group of PIP3 (phosphatidylinositol 3,4,5-trisphosphate) .

HY-103224R

PIT-1 (Standard)	Reference Standards PI3K	Cancer
PIT-1 (Standard) is the analytical standard of PIT-1. This product is intended for research and analytical applications. PIT-1 is a selective PIP3 (phosphatidylinositol 3,4,5-trisphosphate) antagonist. PIT-1 inhibits cancer cell survival and induces apoptosis by inhibition of PIP3 dependent PI3K / Akt signaling. PIT-1 exhibits antitumor activity in vivo .

HY-179543

PtdIns-(3,4,5)-P3-(1-stearoyl, 2-arachidonoyl) sodium	Endogenous Metabolite	Others
PtdIns-(3,4,5)-P3-(1-stearoyl, 2-arachidonoyl) sodium is a specific molecular form of phosphatidylinositol-3,4,5-trisphosphate (PIP3). PIP3 is the core lipid messenger in the tyrosine kinase pathway, regulating cell proliferation, survival and metabolism by recruiting effector proteins. Its abnormality is associated with cancer. PtdIns-(3,4,5)-P3-(1-stearoyl, 2-arachidonoyl) sodium can be used for studying lipid signal transduction .

HY-E70855

PKCζ Recombinant Human Active Protein Kinase	PKC	Cancer
PKCζ is a member of the atypical PKC subfamily and has been widely implicated in the regulation of cellular functions. The major activation pathway of PKCζ depends on phosphatidylinositol (PI)-3,4,5-trisphosphate (PIP(3)), which is mainly produced by PI-3 kinase. PKCζ Recombinant Human Active Protein Kinase is a recombinant PKCζ protein that can be used to study PKCζ-related functions .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-114457

Phosphatidylinositol 4,5-bisphosphate L-alpha-phosphatidylinositol-4,5-bisphosphate; (PtdIns)-(4,5)-P2	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Lipid Source Classification	Phospholipase
Phosphatidylinositol 4,5-bisphosphate (L-alpha-Phosphatidylinositol-4,5-bisphosphate) is a plasma membrane lipid that is enriched in the cytoplasmic leaflet of the plasma membrane. Phosphatidylinositol 4,5-bisphosphate serves as a substrate for phospholipase C and class I PI3K, generating diacylglycerol, inositol (1,4,5)-trisphosphate, and phosphatidylinositol (3,4,5)-trisphosphate. Phosphatidylinositol 4,5-bisphosphate contributes to lamellipodial protrusion, directional cell migration, focal adhesion lipid generation, and trafficking of the GABA_A receptor. Phosphatidylinositol 4,5-bisphosphate can be used in research related to acute lung injury and pulmonary edema .

HY-W127317

Inositol 1,3,4,5-tetraphosphate	Microorganisms Source Classification	Biochemical Assay Reagents
Inositol 1,3,4,5-tetraphosphate is the head group of PIP3 (phosphatidylinositol 3,4,5-trisphosphate) .

Cat. No.	Product Name	Chemical Structure

HY-146946S

*D-Myo-phosphatidylinositol* 3,4,5-trisphosphate diC16-d5**
D-Myo-phosphatidylinositol 3,4,5-trisphosphate diC16-d₅ is deuterium labeled D-Myo-phosphatidylinositol 3,4,5-trisphosphate diC16.

Host:	Mouse (1) Rabbit (2)
Reactivity:	Human (2) human (1)
Application:	IHC-P (2) ICC/IF (2) IF-Tissue (1) IP (3) WB (3) FC (1) ELISA (1)
Isotype:	IgG (2) IgG2b (1)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (2) Recombinant (2)
Modification:	Phosphorylated (1) Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P810076

	SKIP Antibody (YA9420) EC:3.1.3.36, EC:3.1.3.56, EC:3.1.3.86, Inositol polyphosphate 5-phosphatase K, phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase	WB, ICC/IF, IF-Tissue, IHC-P, IP, ELISA	human
	SKIP Antibody (YA9420) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to SKIP.

HY-P83087

	SHIP1 Antibody (YA2832) INPP5D; SHIP; SHIP1; phosphatidylinositol 3; 4; 5-trisphosphate 5-phosphatase 1; Inositol polyphosphate-5-phosphatase of 145 kDa; SIP-145; SH2 domain-containing inositol 5'-phosphatase 1; SH2 domain-containing inositol phosphatase 1; SHIP-1	WB, IHC-P, IP, FC	Human
	SHIP1 Antibody (YA2832) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SHIP1.

HY-P83344

	Phospho-SHIP1 (Tyr1020) Antibody (YA3089) INPP5D; SHIP; SHIP1; phosphatidylinositol 3; 4; 5-trisphosphate 5-phosphatase 1; Inositol polyphosphate-5-phosphatase of 145 kDa; SIP-145; SH2 domain-containing inositol 5'-phosphatase 1; SH2 domain-containing inositol phosphatase 1; SHIP-1	WB, ICC/IF, IP	Human
	Phospho-SHIP1 (Tyr1020) Antibody (YA3089) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-SHIP1 (Tyr1020).

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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