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phosphoribosyl

" in MedChemExpress (MCE) Product Catalog:

By Targets:	NAMPT (2) DNA/RNA Synthesis (1) Endogenous Metabolite (2)
By Research Areas:	Cancer (3) Metabolic Disease (2)

6

Inhibitors & Agonists

2

Natural
Products

2

Recombinant Proteins

Targets Recommended: NAMPT

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Phosphoribosyl pyrophosphate pentasodium PRPP pentasodium	Endogenous Metabolite	Others
Phosphoribosyl pyrophosphate (PRPP) pentasodium is an important metabolite required in the biosynthesis of purine and pyrimidine nucleotides, the amino acids histidine and tryptophan, and the cofactors NAD and NADP .

Teglarinad chloride GMX1777; EB-1627	NAMPT	Cancer
Teglarinad chloride (GMX1777) is a proagent of GMX1778 (a nicotinamide phosphoribosyl transferase inhibitor). Teglarinad chloride exhibits antitumor activity in mice can be attributed to inhibition of NAMPT. Teglarinad chloride also enhances radiation efficacy, mediated by interference with DNA repair and antiangiogenesis .

Orotidine 5′-monophosphate trisodium Orotidine monophosphate trisodium; Orotidylic acid trisodium	Endogenous Metabolite DNA/RNA Synthesis	Metabolic Disease
Orotidine 5'-monophosphate trisodium is a pyrimidine nucleotide. Orotidine 5'-monophosphate trisodium is synthesized via the de novo synthesis pathway for DNA synthesis in a large number of microorganisms including M. tuberculosis, S. cerevisiae, S. typhimurium and P. falciparum to name a few. The synthesis of orotidine 5'-monophosphate trisodium uses phosphoribosyl pyrophosphate (PRPP) and orotic acid (OA) as the substrates catalyzed by orotate phosphoribosyltransferase (OPRT) .

GNE-618	NAMPT	Cancer
GNE-618 is a potent, orally active *nicotinamide phosphoribosyl* transferase (NAMPT) inhibitor with an IC₅₀** of 6 nM. GNE-618 depletes NAD levels and induces tumor cell death. Anti-tumor activity .

HY-W070294

8-Azahypoxanthine

Others Cancer

8-Azahypoxanthine is an inhibitor of hypoxanthine-guanine phosphoribosyl transferase (HGPRT). 8-Azahypoxanthine has antitumor activity .

Potassium oxonate 3 Publications Verification Potassium azaorotate; Potassium otastat; Oteracil potassium	Others	Metabolic Disease
Potassium oxonate is an inhibitor of uricase, inhibits the phosphorylation of 5-FU to 5-fluorouridine-5'-monophosphate catalyzed by pyrimidine phosphoribosyl-transferase in a different manner from allopurinol in cell-free extracts and intact cells in vitro.

Species:	Human (2)
Tag:	His (2) SUMO (1)
Source:	HEK293 (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

	PRPS2 Protein, Human (HEK293, His) Ribose-Phosphate Pyrophosphokinase 2; PPRibP; phosphoribosyl Pyrophosphate Synthase II; PRS-II; PRPS2	Human	HEK293
	The PRPS2 protein plays a key role in catalyzing the synthesis of phosphoribosyl pyrophosphate (PRPP), a key intermediate in nucleotide synthesis. By promoting the conversion of ribose 5-phosphate and ATP to PRPP, PRPS2 contributes to the availability of PRPP in various cellular processes, including de novo biosynthesis of purine and pyrimidine nucleotides. PRPS2 Protein, Human (HEK293, His) is the recombinant human-derived PRPS2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PRPS2 Protein, Human (HEK293, His) is 317 a.a., with molecular weight of ~37.0 kDa.

	PRPS1 Protein, Human (His-SUMO) PRPS1; phosphoribosyl pyrophosphate synthetase 1; deafness, X linked 2, perceptive, congenital , DFN2; ribose-phosphate pyrophosphokinase 1; CMTX5; DFNX1; PRS I; ribose phosphate diphosphokinase 1	Human	E. coli
	The PRPS1 protein plays a crucial role in catalyzing the synthesis of phosphoribosyl pyrophosphate (PRPP), a key intermediate in nucleotide synthesis. By promoting the conversion of ribose 5-phosphate and ATP to PRPP, PRPS1 contributes to the availability of PRPP in various cellular processes, including de novo biosynthesis of purine and pyrimidine nucleotides. PRPS1 Protein, Human (His-SUMO) is the recombinant human-derived PRPS1 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of PRPS1 Protein, Human (His-SUMO) is 317 a.a., with molecular weight of 50.7 kDa.

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