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photoswitchable

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By Targets:	Bcr-Abl (2) Biochemical Assay Reagents (3) CXCR (1) Drug Intermediate (1) Fluorescent Dye (1) HCN Channel (2) Histamine Receptor (1) Kinesin (1) LPL Receptor (1) NAMPT (1) Potassium Channel (1) PROTACs (2) Sodium Channel (4) TRP Channel (4)
By Research Areas:	Cancer (4) Cardiovascular Disease (2) Inflammation/Immunology (2) Metabolic Disease (3) Neurological Disease (3)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W106234

4-(Phenyldiazenyl)benzoic acid	TRP Channel	Others
4-(Phenyldiazenyl)benzoic acid is a photosensitive and photoswitchable TRPA1 agonist that can be used as pharmacological tools for study of pain signaling.

HY-163445

NAMPT activator-6	NAMPT	Cancer
NAMPT activator-6 is a NAMPT activator, a regulatory molecule for the optical control system of NAMPT and NAD+. NAMPT activator-6 can be used to design efficient photoswitchable proteolysis-targeting chimeras (PS-PROTACs) to achieve up-down reversible regulation of NAMPT and NAD+ in a light-dependent manner and reduce the toxicity associated with inhibitor-based PS-PROTACs. PS-PROTAC can be used to achieve antitumor activity, NAMPT, and NAD+ modulation in vivo via optical manipulation .

HY-161092A

KIO-301 chloride hydrochloride	HCN Channel Potassium Channel	Neurological Disease
KIO-301 chloride hydrochloride is an azobenzene photoswitchable compound that blocks voltage-gated ion channels, including hyperpolarization-activated cyclic nucleotide gating (HCN, during exposure to visible light) ) and voltage-gated potassium channels (voltage-gated potassium channels) .

HY-110358

QAQ dichloride	Sodium Channel	Inflammation/Immunology
QAQ dichloride, a photoswitchable voltage-gated Na_v and K_v channels blocker, blocks channels in its trans form (of the azobenzene photoswitch), but not in its cis form. QAQ dichloride is membrane-impermeant and only infiltrates pain-sensing neurons that express endogenous import channels. QAQ dichloride acts as a light-sensitive analgesic and can be used for studying of signaling mechanisms in acute and chronic pain .

HY-N15794

AzoLPA ammonium	LPL Receptor	Neurological Disease
AzoLPA ammonium is a photoswitchable lipid that activates the Lysophosphatidic acid 1-5 (LPA1-5) receptors’ signaling .

HY-160209

KIO-301	HCN Channel	Cardiovascular Disease
KIO-301 is a photoswitchable HCN channel blocker, and can be used as the vitreous “light switch” molecule that reactivates retinitis pigmentosa .

HY-N15799

trans-AzCA4	Biochemical Assay Reagents	Others
trans-AzCA4 is a photoswitchable lipid .

HY-N15782

18:0-PhoDAG	TRP Channel	Neurological Disease
18:0-PhoDAG is a photoswitchable diacylglycerol (DAG) that allows rapid photoactivation of these DAG-sensitive TRP channels .

HY-110209

AC4	TRP Channel	Others
AC4 is a trans antagonist upon voltageactivation of TRPV1 and as cis antagonist of TRPV1 currents upon stimulation with Capsaicin (HY-10448). AC4 demonstrates that a photoswitchable antagonist and an agonist can be used in concert .

HY-126748

VUF14862	Histamine Receptor	Others
VUF14862 is a stable and fatigue-resistant photoswitchable GPCR antagonist targeting the histamine H3 receptor (H3R) pathway. VUF14862 binds to H3R with >10-fold increased affinity upon 360 nm irradiation. VUF14862 can be used for spatiotemporal studies of H3R signaling .

HY-139904

TRPA1 Antagonist 3	TRP Channel	Others
TRPA1 Antagonist 3 is a photoswitchable TRPA1 agonist that enables optical control of the TRPA1 channel.

HY-N15783

Photoswitchable sphingosine	Biochemical Assay Reagents	Others
Photoswitchable Sphingosine is a photoswitchable lipid. Photoswitchable sphingosine can be used to study the translation of optical stimuli into a reversible cellular response .

HY-126424

OptoDArG	Fluorescent Dye	Others
OptoDArG is a photoswitchable probe that has the activity to recognize lipid-gated pores by controlling TRPC3 channels and can be used as a tool to study the lipid sensing mechanism of TRPC channels.

HY-N15781

Trans-faazo-4	Biochemical Assay Reagents	Metabolic Disease
Trans-FAAzo-4 is a photo-switchable fatty acid analogue used in photo-pharmacology. Trans-FAAzo-4 is able to alter membrane lateral pressure and thus control opening and closing of mechanosensitive ion channels .

HY-161897

CENP-E-IN-2	Kinesin	Cancer
CENP-E-IN-2 (compound 3) is a photoswitchable CENP-E inhibitor, with the pIC₅₀ of 6.82 without light illumination and 5.85 with 365 nm light illumination. CENP-E-IN-2 has antitumor activity .

HY-161414

trans-VUF25471	CXCR	Others
trans-VUF25471 (Compound trans-3e) is a photoswitchable ACKR3 agonist. trans-VUF25471 binds and activates ACKR3 at 10-fold lower concentrations compared to its cis-isomer .

HY-125667

PA1 Photoamiloride-1	Sodium Channel	Metabolic Disease
PA1 is a photoswitchable epithelial sodium channel (ENaC) blocker. PA1 can switch to cis-PA1 at 400nm and trans-PA1 at 500nm. PA1 inhibits δ/αENaC, αβγENaC, and δβγENaC, with IC₅₀ values of 4.3nM, 90 nM, and 390 nM, respectively .

HY-110358A

QAQ	Sodium Channel	Inflammation/Immunology
QAQ dichloride dichloride, a photoswitchable voltage-gated Na_v and K_v channels blocker, blocks channels in its trans form (of the azobenzene photoswitch), but not in its cis form. QAQ dichloride dichloride is membrane-impermeant and only infiltrates pain-sensing neurons that express endogenous import channels. QAQ dichloride dichloride acts as a light-sensitive analgesic and can be used for studying of signaling mechanisms in acute and chronic pain .

HY-D3438

Photoswitchable PM8

HY-N16250

Azo SM	Others	Metabolic Disease
Azo SM is a photoswitchable lipid.

HY-B1255

Cintriamide Cintramide	Drug Intermediate	Others
Cintriamide (Cintramide) (Compound 5) is a key intermediate for the synthesis of photoswitchable epothilone-based microtubule stabiliser .

HY-182334

azo-Q2a	Sodium Channel	Cardiovascular Disease
azo-Q2a is a photoswitchable Na_V1.5 inhibitor. azo-Q2a exists as the trans isomer with low activity in the dark or under 480 nm illumination, and exists as the cis isomer with higher inhibitory potency under 365 nm illumination. azo-Q2a reduces the heart rate of living zebrafish larvae in a light-dependent manner. azo-Q2a can be used for the study of arrhythmias .

HY-180983

Azo-PROTAC-4C-trans	PROTACs Bcr-Abl	Cancer
Azo-PROTAC-4C-trans is a BCR-ABL PROTAC degrader that can efficiently degrade the BCR-ABL fusion protein and ABL protein. Azo-PROTAC-4C-trans exhibits potent selective anti-proliferative activity against K562 cells. Azo-PROTAC-4C-trans allows real-time, reversible regulation of its activity via UV (to inactivate it) /visible light (to activate it) irradiation. Azo-PROTAC-4C-trans can be used for the study of myeloid leukemia .

HY-180985

Azo-PROTAC-4C-cis	PROTACs Bcr-Abl	Cancer
Azo-PROTAC-4C-cis is a BCR-ABL PROTAC degrader, and its degradation efficiency of BCR-ABL is much lower than that of its trans isomer Azo-PROTAC-4C-trans (HY-180983). Azo-PROTAC-4C-cis is the product of the conformational transformation of Azo-PROTAC-4C-trans under ultraviolet (UV) light irradiation. Azo-PROTAC-4C-cis can be converted into highly active Azo-PROTAC-4C-trans under visible light, thereby initiating protein degradation. Azo-PROTAC-4C-cis can be used for the study of myeloid leukemia .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N15794

AzoLPA ammonium	Lipid	LPL Receptor
AzoLPA ammonium is a photoswitchable lipid that activates the Lysophosphatidic acid 1-5 (LPA1-5) receptors’ signaling .

HY-N15799

trans-AzCA4	Lipid	Biochemical Assay Reagents
trans-AzCA4 is a photoswitchable lipid .

HY-N15782

18:0-PhoDAG	Lipid	TRP Channel
18:0-PhoDAG is a photoswitchable diacylglycerol (DAG) that allows rapid photoactivation of these DAG-sensitive TRP channels .

HY-N15783

Photoswitchable sphingosine	Lipid	Biochemical Assay Reagents
Photoswitchable Sphingosine is a photoswitchable lipid. Photoswitchable sphingosine can be used to study the translation of optical stimuli into a reversible cellular response .

HY-N15781

Trans-faazo-4	Lipid	Biochemical Assay Reagents
Trans-FAAzo-4 is a photo-switchable fatty acid analogue used in photo-pharmacology. Trans-FAAzo-4 is able to alter membrane lateral pressure and thus control opening and closing of mechanosensitive ion channels .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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photoswitchable

Inhibitors & Agonists

Fluorescent Dyes

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Natural
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