KIO-301 chloride (hydrochloride)

Cat. No.: HY-161092A Purity: 99.61%: FAQs
Data Sheet SDS COA Handling Instructions

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KIO-301 chloride hydrochloride is an azobenzene photoswitchable compound that blocks voltage-gated ion channels, including hyperpolarization-activated cyclic nucleotide gating (HCN, during exposure to visible light) ) and voltage-gated potassium channels (voltage-gated potassium channels).

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KIO-301 chloride (hydrochloride) Chemical Structure

Size	Price	Stock	Quantity
5 mg	USD 180	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 290	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 580	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 930	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1485	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of KIO-301 chloride (hydrochloride):

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Biological Activity
Purity & Documentation
References
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Description	KIO-301 chloride hydrochloride is an azobenzene photoswitchable compound that blocks voltage-gated ion channels, including hyperpolarization-activated cyclic nucleotide gating (HCN, during exposure to visible light) ) and voltage-gated potassium channels (voltage-gated potassium channels)^[1].
Molecular Weight	544.56
Formula	C₂₉H₃₉Cl₂N₅O
Appearance	Solid
Color	Brown to black
SMILES	[H]Cl.O=C(C[N+](CC)(CC)CC)NC(C=C1)=CC=C1/N=N/C2=CC=C(N(CC3=CC=CC=C3)CC)C=C2.[Cl-]
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	4°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Purity & Documentation	Purity: 99.61% Select Batch: Data Sheet (269 KB) SDS (252 KB) COA (251 KB) HNMR (251 KB) RP-HPLC (116 KB) LCMS (126 KB) Handling Instructions (2659 KB)
References	[1]. Eric Daniels, et al. An Intravitreal 'Photoswitch' Molecule (KIO-301) for Reanimation in Retinitis Pigmentosa: a first-in-human trial. Investigative Ophthalmology & Visual Science June 2023, Vol.64, 5444.