2. PROTAC Protein Tyrosine Kinase/RTK
  3. PROTACs Bcr-Abl
  4. Azo-PROTAC-4C-cis

Azo-PROTAC-4C-cis is a BCR-ABL PROTAC degrader, and its degradation efficiency of BCR-ABL is much lower than that of its trans isomer Azo-PROTAC-4C-trans (HY-180983). Azo-PROTAC-4C-cis is the product of the conformational transformation of Azo-PROTAC-4C-trans under ultraviolet (UV) light irradiation. Azo-PROTAC-4C-cis can be converted into highly active Azo-PROTAC-4C-trans under visible light, thereby initiating protein degradation. Azo-PROTAC-4C-cis can be used for the study of myeloid leukemia.
(Pink: Target Protein Ligand-Linker Conjugates ligand (HY-107447); Blue: Ligands for E3 Ligase and Cereblon ligand (HY-14658); Black: linker).

For research use only. We do not sell to patients.

Azo-PROTAC-4C-cis

Azo-PROTAC-4C-cis Chemical Structure

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Azo-PROTAC-4C-cis Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Abl Bcr-Abl

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Description

Azo-PROTAC-4C-cis is a BCR-ABL PROTAC degrader, and its degradation efficiency of BCR-ABL is much lower than that of its trans isomer Azo-PROTAC-4C-trans (HY-180983). Azo-PROTAC-4C-cis is the product of the conformational transformation of Azo-PROTAC-4C-trans under ultraviolet (UV) light irradiation. Azo-PROTAC-4C-cis can be converted into highly active Azo-PROTAC-4C-trans under visible light, thereby initiating protein degradation. Azo-PROTAC-4C-cis can be used for the study of myeloid leukemia[1]. (Pink: Target Protein Ligand-Linker Conjugates ligand (HY-107447); Blue: Ligands for E3 Ligase and Cereblon ligand (HY-14658); Black: linker).

IC50 & Target[1]

Bcr-Abl

 

Cereblon

 

Molecular Weight

995.50

Formula

C50H47ClN12O7S
SMILES

O=C(C1=C2C=CC=C1NC(C3=CC=C(/N=N\C4=CC=C(OCCCCN5CCN(C6=CC(NC7=NC=C(C(NC8=C(C)C=CC=C8Cl)=O)S7)=NC(C)=N6)CC5)C=C4)C=C3)=O)N(C(CC9)C(NC9=O)=O)C2=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Azo-PROTAC-4C-cis Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Azo-PROTAC-4C-cisPROTACsBcr-AblAzo-PROTACprotein degradationphotoswitchableBCR-ABLcis-trans isomerizationlight controlubiquitin-proteasome systemreversible knockdownInhibitorinhibitorinhibit

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