Azo-PROTAC-4C-cis
Azo-PROTAC-4C-cis is a BCR-ABL PROTAC degrader, and its degradation efficiency of BCR-ABL is much lower than that of its trans isomer Azo-PROTAC-4C-trans (HY-180983). Azo-PROTAC-4C-cis is the product of the conformational transformation of Azo-PROTAC-4C-trans under ultraviolet (UV) light irradiation. Azo-PROTAC-4C-cis can be converted into highly active Azo-PROTAC-4C-trans under visible light, thereby initiating protein degradation. Azo-PROTAC-4C-cis can be used for the study of myeloid leukemia.
(Pink: Bcr-Abl ligand (HY-107447); Blue: Cereblon ligand (HY-14658); Black: linker).
For research use only. We do not sell to patients.
- Formula: C50H47ClN12O7S
- Molecular Weight:995.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Bcr-Abl |
Cereblon |
Chemical Information
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Molecular Weight 995.50
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Formula C50H47ClN12O7S
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SMILES
O=C(C1=C2C=CC=C1NC(C3=CC=C(/N=N\C4=CC=C(OCCCCN5CCN(C6=CC(NC7=NC=C(C(NC8=C(C)C=CC=C8Cl)=O)S7)=NC(C)=N6)CC5)C=C4)C=C3)=O)N(C(CC9)C(NC9=O)=O)C2=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Azo-PROTAC-4C-cis Related Classifications
HY-180985 Related Classifications
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