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pyrazole+derivative

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By Targets:	Bacterial (3) Biochemical Assay Reagents (1) Calcium Channel (1) Drug Derivative (1) Drug Intermediate (1) iGluR (2) Isotope-Labeled Compounds (2) Kallikrein (2) Parasite (3) Potassium Channel (1) Reference Standards (2) TRP Channel (1)
By Research Areas:	Cardiovascular Disease (3) Infection (4) Inflammation/Immunology (6) Metabolic Disease (2)

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Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-76228

1H-pyrazole Pyrazole	Parasite iGluR	Infection
1H-pyrazole (Pyrazole) is a five-membered heterocyclic compound, and its derivatives are orally effective antimalarial and antileishmanial agents with the potential to modulate targets such as alcohol dehydrogenase and NMDA receptors. 1H-pyrazole derivatives exhibit inhibitory effects on Plasmodium berghei in infected mice and on promastigotes of Leishmania aethiopica, respectively. 1H-pyrazole can be used in research related to malaria and leishmaniasis .

HY-19408

Pyr10 3 Publications Verification	TRP Channel	Others
Pyr10 is a pyrazole derivative and a selective TRP cation 3 (TRPC3) inhibitor. Pyr10 inhibits Ca ²⁺ influx in carbachol-stimulated TRPC3-transfected HEK293 cells with an IC₅₀ of 0.72 μM (IC₅₀ of 13.08 μM for store operated Ca ²⁺ entry in BRL-2H3 cells). Pyr10 has the ability to distinguish between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1)/Orai1 channels .

HY-B1137

Ramifenazone Isopropylaminoantipyrine	Bacterial	Inflammation/Immunology
Ramifenazone (Isopropylaminoantipyrine) is a pyrazole derivative and acts as a non-steroidal anti-inflammatory agent (NSAID). Ramifenazone has analgesic, antipyretic, anti-inflammatory and antimicrobial activities .

HY-145568

Feniralstat KVD-824	Kallikrein	Cardiovascular Disease Metabolic Disease
Feniralstat (compound 30), a pyrazole derivative, is a potent kallikrein inhibitor with an IC₅₀ of 6.7 nM for Human plasma kallikrein (pKal). Feniralstat has no inhibition on Human KLKl, Human FXIa, Human Factor Xlla (all IC₅₀>40 μM) .

HY-145568A

Feniralstat hydrochloride	Kallikrein	Cardiovascular Disease Metabolic Disease
Feniralstat (compound 30) hydrochloride, a pyrazole derivative, is a potent kallikrein inhibitor with an IC₅₀ of 6.7 nM for Human plasma kallikrein (pKal). Feniralstat has no inhibition on Human KLKl, Human FXIa, Human Factor Xlla (all IC₅₀>40 μM) .

HY-W779244

*1H-Pyrazole-3,4,5-d3*	Isotope-Labeled Compounds Biochemical Assay Reagents Drug Intermediate	Infection
1H-Pyrazole-3,4,5-d₃ is the deuterium labeled 1H-pyrazole (HY-76228). 1H-pyrazole is a nitrogen-containing heterocyclic compound composed of a five-membered ring and two nitrogen atoms. 1H-pyrazole is an intermediate in organic synthesis. 1H-pyrazole coordinates with metal ions. 1H-pyrazole derivatives have antibacterial, anti-inflammatory, anti-malarial, and anti-leishmanial activities .

HY-128546

Flupranone	Drug Derivative	Cardiovascular Disease Inflammation/Immunology
Flupranone is a pyrazole derivatives with antiinflammatory and antihypertensive properties .

HY-173618

LQFM020	Calcium Channel Potassium Channel	Inflammation/Immunology
LQFM020 is an orally active pyrazole derivative. LQFM020 inhibits Ca ⁺ and activates K ⁺ and NO/cGMP channels to inhibit vasoconstriction. LQFM020 has anti-inflammatory and anti-analgesic activities .

HY-B1137S

Ramifenazone-d7	Isotope-Labeled Compounds Bacterial	Inflammation/Immunology
Ramifenazone-d₇ is the deuterium labeled Ramifenazone. Ramifenazone (Isopropylaminoantipyrine) is a pyrazole derivative and acts as a non-steroidal anti-inflammatory agent (NSAID). Ramifenazone has analgesic, antipyretic, anti-inflammatory and antimicrobial activities .

HY-170358

Antileishmanial agent-31	Parasite	Infection
Antileishmanial agent-31 (Compound p1) is a pyrazole derivative. Antileishmanial agent-31 has anti-leishmania activity with an IC₅₀ of 35.53 μg/mL. In addition, Antileishmanial agent-31 has high stability. Antileishmanial agent-31 can be used for anti-leishmaniasis research .

HY-76228R

*1H-pyrazole* (Standard)** Pyrazole (Standard)	Reference Standards Parasite iGluR	Infection Inflammation/Immunology
1H-pyrazole (Standard) is the analytical standard of 1H-pyrazole. This product is intended for research and analytical applications. 1H-pyrazole (Pyrazole) is a five-membered heterocyclic compound, and its derivatives are orally effective antimalarial and antileishmanial agents with the potential to modulate targets such as alcohol dehydrogenase and NMDA receptors. 1H-pyrazole derivatives exhibit inhibitory effects on Plasmodium berghei in infected mice and on promastigotes of Leishmania aethiopica, respectively. 1H-pyrazole can be used in research related to malaria and leishmaniasis .

HY-B1137R

Ramifenazone (Standard) Isopropylaminoantipyrine (Standard)	Reference Standards Bacterial	Inflammation/Immunology
Ramifenazone (Standard) is the analytical standard of Ramifenazone. This product is intended for research and analytical applications. Ramifenazone (Isopropylaminoantipyrine) is a pyrazole derivative and acts as a non-steroidal anti-inflammatory agent (NSAID). Ramifenazone has analgesic, antipyretic, anti-inflammatory and antimicrobial activities .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-76228

1H-pyrazole Pyrazole	Alkaloids Structural Classification Classification of Application Fields Other Alkaloids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Parasite iGluR
1H-pyrazole (Pyrazole) is a five-membered heterocyclic compound, and its derivatives are orally effective antimalarial and antileishmanial agents with the potential to modulate targets such as alcohol dehydrogenase and NMDA receptors. 1H-pyrazole derivatives exhibit inhibitory effects on Plasmodium berghei in infected mice and on promastigotes of Leishmania aethiopica, respectively. 1H-pyrazole can be used in research related to malaria and leishmaniasis .

HY-76228R

*1H-pyrazole* (Standard)** Pyrazole (Standard)	Alkaloids Structural Classification Other Alkaloids Endogenous metabolite Source Classification	Reference Standards Parasite iGluR
1H-pyrazole (Standard) is the analytical standard of 1H-pyrazole. This product is intended for research and analytical applications. 1H-pyrazole (Pyrazole) is a five-membered heterocyclic compound, and its derivatives are orally effective antimalarial and antileishmanial agents with the potential to modulate targets such as alcohol dehydrogenase and NMDA receptors. 1H-pyrazole derivatives exhibit inhibitory effects on Plasmodium berghei in infected mice and on promastigotes of Leishmania aethiopica, respectively. 1H-pyrazole can be used in research related to malaria and leishmaniasis .

Cat. No.	Product Name	Chemical Structure

HY-W779244

*1H-Pyrazole-3,4,5-d3*
1H-Pyrazole-3,4,5-d₃ is the deuterium labeled 1H-pyrazole (HY-76228). 1H-pyrazole is a nitrogen-containing heterocyclic compound composed of a five-membered ring and two nitrogen atoms. 1H-pyrazole is an intermediate in organic synthesis. 1H-pyrazole coordinates with metal ions. 1H-pyrazole derivatives have antibacterial, anti-inflammatory, anti-malarial, and anti-leishmanial activities .

1H-Pyrazole-3,4,5-d3

1H-Pyrazole-3,4,5-d₃ is the deuterium labeled 1H-pyrazole (HY-76228). 1H-pyrazole is a nitrogen-containing heterocyclic compound composed of a five-membered ring and two nitrogen atoms. 1H-pyrazole is an intermediate in organic synthesis. 1H-pyrazole coordinates with metal ions. 1H-pyrazole derivatives have antibacterial, anti-inflammatory, anti-malarial, and anti-leishmanial activities .

HY-B1137S

Ramifenazone-d7
Ramifenazone-d₇ is the deuterium labeled Ramifenazone. Ramifenazone (Isopropylaminoantipyrine) is a pyrazole derivative and acts as a non-steroidal anti-inflammatory agent (NSAID). Ramifenazone has analgesic, antipyretic, anti-inflammatory and antimicrobial activities .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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pyrazole+derivative

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products