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pyridine ligand

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By Targets:	E3 Ligase Ligand-Linker Conjugates (1) Androgen Receptor (1) Biochemical Assay Reagents (3) Drug Intermediate (2) Environmental Pollutants (2) Liposome (1) MOFs (1)
By Research Areas:	Cancer (2)
Oligonucleotides:	Phospholipids (1)

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Biochemical Assay Reagents

Peptides

Natural
Products

Oligonucleotides

Targets Recommended: Target Protein Ligand-Linker Conjugates E3 Ligase Ligand-Linker Conjugates PD-1/PD-L1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y1024

Pyridine-2,6-dicarboxylic acid 2,6-pyridinedicarboxylic acid	Environmental Pollutants MOFs	Others
Pyridine-2,6-dicarboxylic acid is a dicarboxylic acid containing a pyridine ring with unique chemical properties that make it an important ingredient in a variety of industrial processes. Pyridine-2,6-dicarboxylic acid is commonly used as a ligand for metal ions, a building block in the synthesis of pharmaceuticals and organic compounds, and a precursor in the production of pigments and dyes.

HY-112766

DPyPE	Liposome	Others
DPyPE is a neutral phosphatidylethanolamine lipid composed of a polyisoprene alkyl chain with two pyridine-containing phosphine ligands. DPyPE is mainly used in liposome formulations and to enhance the efficiency of gene delivery in vitro and in vivo. For example, DPyPE can be mixed with cationic lipids such as VC1052 (HY-156616) (in a 1:1 ratio) to form the vaccine adjuvant Vaxfectin (HY-142998). DPyPE assists VC1052 in binding to negatively charged pDNA to form a uniform liposome complex by regulating the fluidity and stability of the liposome membrane .

HY-W007648

Methyl 3-aminopropanoate hydrochloride β-Alanine methyl ester hydrochloride	Drug Intermediate Biochemical Assay Reagents	Others
Methyl 3-aminopropanoate (β-Alanine methyl ester) hydrochloride is a compound prepared by esterification of Β-Alanine (I). Methyl 3-aminopropanoate hydrochloride can be used in the synthesis of bidentate pyridine-acid ligand. Methyl 3-aminopropionate hydrochloride can be used for proteomics research .

HY-148340

24RBPyBC	Biochemical Assay Reagents	Others
24RBPyBC is a dinucleating macrocyclic ligand, it contains phenolate pyridine, bipyridine, and amino groups form dinuclear Fe(II) and Fe(III) complexes .

HY-163222

4-Methylanisole-dihydrouracil-imidazo[1,2-a]pyridine-piperidine-NH-Boc	E3 Ligase Ligand-Linker Conjugates	Cancer
4-Methylanisole-dihydrouracil-imidazo[1,2-a]pyridine-piperidine-NH-Boc is a conjugate of E3 ubiquitin ligase ligand-Linker, which can be used to synthesize complete PROTACs molecules.

HY-176068

3-Cl-Pyridine-amide-acrylaldehyde-piperazine	Androgen Receptor	Cancer
3-Cl-Pyridine-amide-acrylaldehyde-piperazine is a synthetic intermediate of LO-4-25 (HY-176067). LO-4-25 is an androgen receptor (AR) DNA binding domain ligand linked via a linker to the truncated fumaramide handle. LO-4-25 shows robust degradation of both AR and AR-V7 in 22Rv1 cells .

HY-W131404

Boc-Aeg-OEt	Biochemical Assay Reagents	Others
Boc-Aeg-OEt is an aminoethylglycine monomer based on a Boc- and ethyl ester-protected AEG backbone, with substitution by a pyridine ligand. Boc-Aeg-OEt reduces steric hindrance in a series of dipeptide synthesis reactions, and has higher solubility in common solvents than the Fmoc-aeg-OtBu backbone .

HY-W075796

Copper(I) thiocyanate	Environmental Pollutants Drug Intermediate	Others
Copper (I) thiocyanate is a monovalent copper pseudohalide that exists in two crystalline forms, α and β, both containing bridging thiocyanate groups. Copper (I) thiocyanate can form coordination complexes with ligands such as triphenylphosphine and pyridine .

Cat. No.	Product Name	Type

HY-Y1024

Pyridine-2,6-dicarboxylic acid 2,6-pyridinedicarboxylic acid	Biochemical Assay Reagents
Pyridine-2,6-dicarboxylic acid is a dicarboxylic acid containing a pyridine ring with unique chemical properties that make it an important ingredient in a variety of industrial processes. Pyridine-2,6-dicarboxylic acid is commonly used as a ligand for metal ions, a building block in the synthesis of pharmaceuticals and organic compounds, and a precursor in the production of pigments and dyes.

Pyridine-2,6-dicarboxylic acid

2,6-pyridinedicarboxylic acid

Biochemical Assay Reagents

Pyridine-2,6-dicarboxylic acid is a dicarboxylic acid containing a pyridine ring with unique chemical properties that make it an important ingredient in a variety of industrial processes. Pyridine-2,6-dicarboxylic acid is commonly used as a ligand for metal ions, a building block in the synthesis of pharmaceuticals and organic compounds, and a precursor in the production of pigments and dyes.

Cat. No.	Product Name	Target	Research Area

HY-W131404

Boc-Aeg-OEt	Biochemical Assay Reagents	Others
Boc-Aeg-OEt is an aminoethylglycine monomer based on a Boc- and ethyl ester-protected AEG backbone, with substitution by a pyridine ligand. Boc-Aeg-OEt reduces steric hindrance in a series of dipeptide synthesis reactions, and has higher solubility in common solvents than the Fmoc-aeg-OtBu backbone .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-Y1024

Pyridine-2,6-dicarboxylic acid 2,6-pyridinedicarboxylic acid	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source Classification	Environmental Pollutants MOFs
Pyridine-2,6-dicarboxylic acid is a dicarboxylic acid containing a pyridine ring with unique chemical properties that make it an important ingredient in a variety of industrial processes. Pyridine-2,6-dicarboxylic acid is commonly used as a ligand for metal ions, a building block in the synthesis of pharmaceuticals and organic compounds, and a precursor in the production of pigments and dyes.

Cat. No.	Product Name		Classification

HY-112766

DPyPE		Phospholipids
DPyPE is a neutral phosphatidylethanolamine lipid composed of a polyisoprene alkyl chain with two pyridine-containing phosphine ligands. DPyPE is mainly used in liposome formulations and to enhance the efficiency of gene delivery in vitro and in vivo. For example, DPyPE can be mixed with cationic lipids such as VC1052 (HY-156616) (in a 1:1 ratio) to form the vaccine adjuvant Vaxfectin (HY-142998). DPyPE assists VC1052 in binding to negatively charged pDNA to form a uniform liposome complex by regulating the fluidity and stability of the liposome membrane .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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pyridine ligand

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

NaturalProducts

Oligonucleotides

Natural
Products