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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
9 Results for "
reductive cleavage
" in MedChemExpress (MCE) Product Catalog:
Products (9)
9 Results for "reductive cleavage" in MCE Product Catalog:
Cat. No.: HY-P2661
CAS No.: 78832-65-2
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Synonyms: Elastase Inhibitor III
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Cat. No.: HY-115590
CAS No.: 1902983-63-4
JP-11646 is a pan-PIM inhibitor with increased potency against PIM2 (IC50 = 0.5 nM). JP11646 is freely reversible and ATP non-competitive. JP-11646 results in a decrease of PIM1, 2, and 3 mRNA. JP-11646 can effectively inhibit cell viability in small cell lung cancer (SCLC) and large cell neuroendocrine carcinomas of the lung (LCNEC). JP-11646 can cause a decrease in p-4EBP-1 protein, increasing the cleavage of caspases while decreasing caspase-3. JP-11646 induces apoptosis or necroptosis in cells. JP-11646 leads to reductions in MYC paralogs. JP-11646 can be used for the study of SCLC, LCNEC, human acute leukemia (AML), multiple myeloma (MM), and triple-negative breast cancer (TNBC) .
Synonyms: VU0285655-1
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BML-280 (VU0285655-1) is a potent and selective phospholipase D2 (PLD2) inhibitor. BML-280 has the ability to prevent caspase-3 cleavage and reduction in cell viability induced by high glucose. BML-280 can be used for rheumatoid arthritis research .
Cat. No.: HY-174302
CAS No.: 3103925-33-0
PIM-1/HDAC-IN-2 is a robust PIM/HDAC inhibitor (IC50 = 0.11 μM in MV4-11cells), which exerts a synergistic antiproliferative effect through a dual mechanism of inhibiting PIM1 kinase and selectively inhibiting HDAC6. PIM-1/HDAC-IN-2 induces cell apoptosis. PIM-1/HDAC-IN-2 remarkably induces the cleavage of PARP, thereby initiating the arrest of the cell cycle in G1 phase and a reduction in S phase. PIM-1/HDAC-IN-2 demonstrates significant anticancer efficacyin the MV4-11 xenograft model without notable toxicity[1].
Cat. No.: HY-137802
CAS No.: 53199-56-7
Synonyms: S-Adenosyl-L-homocysteine sulfone
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SAHO2 is the sulfone form of the methyl donor S-(5'-adenosyl)-L-methionine chloride (SAM) and serves as a substrate for radical SAM enzymes .
Cat. No.: HY-W009458
CAS No.: 3318-43-2
Synonyms: 3-IP sodium
Cat. No.: HY-W078592
CAS No.: 2642-80-0
Synonyms: 1,1-Bis(p-chlorophenyl)-2-chloroethane
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1-Chloro-4-benzene (1,1-Bis (p-chlorophenyl)-2-chloroethane) (Compound DDMS) is the dechlorination reduction product of DDT (insecticide) and DDD .
Cat. No.: HY-P2661A
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
