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respiratory condition

" in MedChemExpress (MCE) Product Catalog:

3

Inhibitors & Agonists

1

Peptides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-101180
    C2 Ceramide
    2 Publications Verification

    Ceramide 2

    		 Phosphatase Mitochondrial Metabolism Apoptosis Autophagy Metabolic Disease Endocrinology
    C2 Ceramide (Ceramide 2) is the main lipid of the stratum corneum and a protein phosphatase 1 (PP1) activator. C2 Ceramide activates PP2A and ceramide-activated protein phosphatase (CAPP). C2 Ceramide induces cells differentiation, autophagy and apoptosis, inhibits mitochondrial respiratory chain complex III. C2 Ceramide is also a skin conditioning agent that protects the epidermal barrier from water loss .
    C2 Ceramide
  • HY-19870C
    Setmelanotide monoacetate
    5+ Cited Publications

    RM-493 monoacetate; BIM-22493 monoacetate; IRC-022493 monoacetate

    		 Melanocortin Receptor Calmodulin AMPK Cardiovascular Disease Metabolic Disease Inflammation/Immunology
    Setmelanotide monoacetate (RM-493 monoacetate) is a blood-brain barrier-permeable, selective MC4R agonist with a Ki value of 2.1 nM for hMC4R. Setmelanotide monoacetate activates the CaMKK2/AMPK signaling pathway. Setmelanotide monoacetate mediates body weight homeostasis, feeding regulation and energy expenditure modulation; it reduces food intake, induces weight loss, decreases obesity severity, increases daytime activity and energy expenditure, lowers levels of leptin, triglycerides, fasting insulin and diastolic blood pressure, improves insulin sensitivity, glucose tolerance and fatty liver condition, and reverses respiratory depression. Setmelanotide monoacetate is applicable to research related to obesity, hyperinsulinemia, fatty liver and respiratory depression .
    Setmelanotide monoacetate
  • HY-185073
    STAT6-IN-11

    		STAT Inflammation/Immunology
    STAT6-IN-11 (example 3) is a STAT6 inhibitor with an EC50 of 6 nM. STAT6-IN-11 inhibits CCL17 secretion in peripheral human whole blood, stimulated through the IL-13-IL- 13 receptor/IL-4 receptor pathway, with an IC50 of 83 nM. STAT6-IN-11 can be used for the study of dermatological condition or a respiratory condition .
    STAT6-IN-11

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