2. Metabolic Enzyme/Protease
  3. Lipoxygenase
  4. Setileuton

Setileuton (MK-0633) is an inhibitor for 5-lipoxygenase, that inhibits the oxidation of arachidonic acid by recombinant human 5-LO, and the production of LTB4 in calcium ionophore-stimulated human whole blood, with IC50 of 3.9 and 52 nM, respectively.

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Setileuton

Setileuton Chemische Struktur

CAS. Nr. : 910656-27-8

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Beschreibung

Setileuton (MK-0633) is an inhibitor for 5-lipoxygenase, that inhibits the oxidation of arachidonic acid by recombinant human 5-LO, and the production of LTB4 in calcium ionophore-stimulated human whole blood, with IC50 of 3.9 and 52 nM, respectively[1].

In Vivo

Setileuton (5 mg/kg, i.v.; or 20 mg/kg, p.o., single dose) exhibits good pharmacokinetic profils with a half-time T1/2 of 3.3 h, and a bioavailability of 66% in rat model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Klinische Studie
Molekulargewicht

463.38

Formel

C22H17F4N3O4
CAS. Nr.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C=C(C2=CC=C(C=C2)F)C3=CC=C(CNC4=NN=C([C@](CC)(O)C(F)(F)F)O4)C=C3O1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Reinheit & Dokumentation
Verweise
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Setileuton Related Classifications

  • Molaritätsrechner

  • Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Setileuton910656-27-8MK-0633MK0633MK 0633LipoxygenaseLOXchronic obstructive pulmonary diseaseleukotrieneLTB4Inhibitorinhibitorinhibit

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