Sodium bicarbonate, meets analytical specification of Ph. Eur., BP, USP, FCC, E500  (Synonyms: Sodium hydrogen carbonate, meets analytical specification of Ph. Eur., BP, USP, FCC, E500)

Sodium bicarbonate, meets analytical specification of Ph. Eur., BP, USP, FCC, E500 is an inorganic salt that is neutral to slightly alkaline and easily decomposes when exposed to moisture in the air. Sodium bicarbonate can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate is widely used in the fields of food, medicine, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort^{[1][2][3][4][5][6]}.

Sodium bicarbonate (0.06-0.12 M; 48 h) significantly inhibits the growth of bacteria such as Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Saccharomyces cerevisiae^[2].
Sodium bicarbonate (14-44 mM; 20 h) enhances iNOS protein expression and NO production in LPS/IFNγ-stimulated J774.1/JA-4 and RAW264.7 macrophages in a concentration-dependent manner by regulating intracellular and extracellular pH. At 44 mM, NO production increased by 2.7 times^[3].
Sodium bicarbonate (0.3 M; 6 d) inhibits breast cancer cell migration and enhances the toxicity of doxorubicin to triple-negative breast cancer cells by increasing the pH of the tumor microenvironment to 7.39, reducing cell viability to 12%^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sodium bicarbonate (200 mM; add in water, oral daily; 30-60 days) significantly reduces the number of lung, intestinal and diaphragmatic metastases and improves mouse survival in a severe combined immunodeficient (SCID) beige mice MDA-MB-231 adenocarcinoma model^[4][5].
Sodium bicarbonate (0.25 g/kg; oral gavage; single dose) reduces alcohol intake by 20% and significantly reduces alcohol preference by 20% in mice^[6].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

84.01

NaHCO₃

144-55-8

O=[C]OO[NaH]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Forsythe SM, et al. Sodium bicarbonate for the treatment of lactic acidosis. Chest. 2000 Jan;117(1):260-7.  [Content Brief]

  [2]. Corral L G, et al. Antimicrobial activity of sodium bicarbonate: A research note. Journal of food science, 1988, 53(3): 981-982.

  [3]. Kawakami T, et al. Sodium bicarbonate regulates nitric oxide production in mouse macrophage cell lines stimulated with lipopolysaccharide and interferon γ. Nitric Oxide. 2018 Sep 1;79:45-50.  [Content Brief]

  [4]. Robey IF, et al. Bicarbonate increases tumor pH and inhibits spontaneous metastases. Cancer Res. 2009 Mar 15;69(6):2260-8.  [Content Brief]

  [5]. Wang Y, et al. Sodium bicarbonate, an inorganic salt and a potential active agent for cancer therapy. Chinese Chemical Letters, 2021, 32(12): 3687-3695.

  [6]. Lin J, et al. Sodium Bicarbonate Decreases Alcohol Consumption in Mice. Int J Mol Sci. 2024 May 3;25(9):5006.  [Content Brief]