2. GPCR/G Protein Neuronal Signaling Immunology/Inflammation
  3. Histamine Receptor
  4. ST-1006 Maleate

ST-1006 maleate is a potent histamine H4 receptor agonist with a pKi value of 7.94. ST-1006 maleate has anti-inflammatory effect.

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ST-1006 Maleate

ST-1006 Maleate 화학구조

CAS No. : 1196994-12-3

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ST-1006 Maleate Related Antibodies

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제품 설명

ST-1006 maleate is a potent histamine H4 receptor agonist with a pKi value of 7.94. ST-1006 maleate has anti-inflammatory effect[1][2].

In Vitro

ST-1006 (10 μM) maleate is a potent inducer of basophil migration and induces migration of basophils[2].
ST-1006 (0-100 μM) maleate suppress FceRImediated basophil activation and reduces the CD63 and CD203c expression levels on FceRI-activated basophils[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ST-1006 Maleate Related Antibodies
In Vivo

ST-1006 (1-100 mg/kg; s.c.; Male CD-1 mice) maleate has anti-inflammatory effect and displays an antipruritic effect[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male CD-1 mice with pruritus (8-10 weeks and 25-30 g)[1]
Dosage: 1-100 mg/kg
Administration: Subcutaneous injection
Result: Had an antipruritic effect at the non-anti-inflammatory dose of 30 mg/kg.
분자량

599.42

화학식

C24H28Cl2N6O8
CAS No.
SMILES

OC(/C=C\C(O)=O)=O.ClC(C=CC=C1Cl)=C1CNC2=CC(N3CCN(CC3)C)=NC(N)=N2.OC(/C=C\C(O)=O)=O
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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ST-1006 Maleate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ST-10061196994-12-3ST1006ST 1006Histamine Receptoranti-inflammatoryantipruriticbasophilsFceRIInhibitorinhibitorinhibit

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상품명:
ST-1006 Maleate
Cat. No.:
HY-120541A
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