2. JAK/STAT Signaling Stem Cell/Wnt
  3. STAT
  4. STAT3-IN-7

STAT3-IN-7, an aryl sulfonamido azetidine compound, is an orally active STAT3 inhibitor. STAT3-IN-7 has anticancer activities (WO2021016333A1, H182).

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STAT3-IN-7

STAT3-IN-7 Estructura química

No. CAS : 2237955-91-6

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STAT3-IN-7 Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas STAT:

Ver todas las isoformas
STAT3 STAT5 STAT6 STAT1

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Descripciòn

STAT3-IN-7, an aryl sulfonamido azetidine compound, is an orally active STAT3 inhibitor. STAT3-IN-7 has anticancer activities (WO2021016333A1, H182)[1].

Cellular Effect
Cell Line Type Value Description References
MCF-10A EC50
4 3
Compound: 9f
Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability incubated for 72 hrs by CyQuant assay
Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability incubated for 72 hrs by CyQuant assay
[PMID: 33352047]
MCF-10A EC50
4 3
Compound: 9f
Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability incubated for 72 hrs by CyQuant assay
Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability incubated for 72 hrs by CyQuant assay
[PMID: 33352047]
MCF7 EC50
3.6 3
Compound: 9f
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by CyQuant assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by CyQuant assay
[PMID: 33352047]
MCF7 EC50
3.6 3
Compound: 9f
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by CyQuant assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by CyQuant assay
[PMID: 33352047]
MDA-MB-231 EC50
3.3 3
Compound: 9f
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by CyQuant assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by CyQuant assay
[PMID: 33352047]
MDA-MB-231 EC50
3.3 3
Compound: 9f
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by CyQuant assay
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by CyQuant assay
[PMID: 33352047]
MDA-MB-468 EC50
1.5 3
Compound: 9f
Antiproliferative activity against human MDA-MB-468 cells harbouring STAT3 assessed as reduction in cell viability incubated for 72 hrs by CyQuant assay
Antiproliferative activity against human MDA-MB-468 cells harbouring STAT3 assessed as reduction in cell viability incubated for 72 hrs by CyQuant assay
[PMID: 33352047]
MDA-MB-468 EC50
1.5 3
Compound: 9f
Antiproliferative activity against human MDA-MB-468 cells harbouring STAT3 assessed as reduction in cell viability incubated for 72 hrs by CyQuant assay
Antiproliferative activity against human MDA-MB-468 cells harbouring STAT3 assessed as reduction in cell viability incubated for 72 hrs by CyQuant assay
[PMID: 33352047]
Peso molecular

647.62

Fòrmula

C30H26F5N5O4S
No. CAS
SMILES

O=C1NC=NC2=C1C=CC(N(C([C@H]3CCN3S(=O)(C4=C(C(F)=C(C(F)=C4F)F)F)=O)=O)CC5=CC=C(C=N5)C6CCCCC6)=C2
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
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STAT3-IN-7 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STAT3-IN-72237955-91-6STATSTAT3 inhibitoranticancer activitiesorally activeInhibitorinhibitorinhibit

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STAT3-IN-7
Cat. No.:
HY-144870
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