Substance P (6-11) 

Substance P (6-11) is the C-terminal hexapeptideamide of Substance P (HY-P0201). Substance P (6-11) binds to NK-1 tachykinin receptor. Substance P (6-11) shows depolarization of motoneurons and a hypotensive effect^[1][2].

Substance P(6-11) stimulates [³H]-inositol monophosphate ([³H]-IP1) formation with an EC₅₀ value 4 nM in rat urinary bladder^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Substance P (6-11) (0.1-10 nM) inhibits insulin and glucagon secretion from the rat pancreas in a dose-dependent manner. In the canine pancreas, by contrast, Substance P (6-11) (1-10 nM), potentiates the release of insulin, glucagon, and somatostatin^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

740.91

C₃₆H₅₂N₈O₇S

51165-07-2

QFFGLM-NH2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Y Torrens, et al. Substance P(6-11) and natural tachykinins interact with septide-sensitive tachykinin receptors coupled to a phospholipase C in the rat urinary bladder. Neuropeptides. 1997 Jun;31(3):243-51.  [Content Brief]

  [2]. Y Chiba, et al. Effects of substance P and substance P-(6-11) on hormone release from isolated perfused pancreas: their opposite actions on rat and canine islets. Endocrinology. 1985 Nov;117(5):1996-2000.  [Content Brief]