2. Immunology/Inflammation
  3. Complement System
  4. Sutimlimab

Sutimlimab  (Synonyms: BIVV009; IPN-009; TNT009)

Cat. No.: HY-P99050 Pureza: 98.81%
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Sutimlimab is a humanized monoclonal IgG4 antibody. Sutimlimab inhibits complement protein component 1, s subcomponent (C1s). Sutimlimab blocks C3 and C4 activation. Sutimlimab can be used for the research of cold agglutinin disease and complement-mediated hemolytic uremic syndrome.

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No. CAS : 2049079-64-1

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Sutimlimab Related Antibodies

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Descripciòn

Sutimlimab is a humanized monoclonal IgG4 antibody. Sutimlimab inhibits complement protein component 1, s subcomponent (C1s). Sutimlimab blocks C3 and C4 activation. Sutimlimab can be used for the research of cold agglutinin disease and complement-mediated hemolytic uremic syndrome[1][2][3].

Isotype

Human IgG4 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

C1s
In Vitro

Sutimlimab (30 μg/mL) can significantly protect CD46KO cells from complement-mediated cell death, with a relative 1-hour luminescence recovery rate of 73%[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sutimlimab Related Antibodies
Ensayo clínico
Gene ID

716  [NCBI]

Accession
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Peso molecular

144.8 kDa

No. CAS
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Sutimlimab]
Envío

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG4 kappa
Biological Activity
  • Immobilized C1s/Complement component C1s Protein, Human can bind Sutimlimab. The EC50 for this effect is 16.31 ng/mL.
  • Flow Cytometry analysis of A549 cells labelling C1s (red) with Sutimlimab (anti-C1s) (HY-P99050). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG4 kappa (HY-P99003, blue) was used as the isotype control.
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Referencias
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Sutimlimab Related Classifications

  • Calculadora de molaridad

  • Calculadora de dilución

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sutimlimab2049079-64-1BIVV009 IPN-009 TNT009BIVV 009BIVV-009IPN009IPN 009IPN-009TNT009TNT 009TNT-009Complement Systemcomplement protein component 1s subcomponentC1s inhibitorcold agglutinin diseaseInhibitorinhibitorinhibit

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Nombre del producto:
Sutimlimab
Cat. No.:
HY-P99050
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