1. Metabolic Enzyme/Protease
  2. FXR
  3. Tauro-β-muricholic acid sodium

Tauro-β-muricholic acid sodium (Synonyms: T-βMCA sodium)

Cat. No.: HY-135103 Purity: >95.0%
Handling Instructions

Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite, is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC50 of 40 μM.

For research use only. We do not sell to patients.

Tauro-β-muricholic acid sodium Chemical Structure

Tauro-β-muricholic acid sodium Chemical Structure

CAS No. : 145022-92-0

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Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Tauro-β-muricholic Acid sodium (T-βMCA sodium), a endogenous metabolite, is a competitive and reversible farnesoid X receptor (FXR) antagonist, with an IC50 of 40 μM[1][2][3].

IC50 & Target

IC50: 40 μM (FXR)[1]

In Vitro

T-βMCA sodium inhibits FXR reporter activity in the CRC cell line HT29 (EC50 ~10 μM)[3].
T-βMCA sodium dose-dependently increases WNT signaling in HT29 and HCT116 cells[3].
T-βMCA sodium induces proliferation and DNA damage in Lgr5+ cells[3].

In Vivo

T-βMCA sodium (400 mg/kg; i.g.; twice a week; for 6 weeks) can effectively recapitulate the ability of HFD to promote CRC progression[3].
T-βMCA sodium treatment also significantly increases levels of serum cytokines, including IFN-γ, IL-6, and IL-17[3].

Animal Model: APCmin/+ mice[3]
Dosage: 400 mg/kg
Administration: Oral gavage; twice a week; for 6 weeks
Result: Markedly decreased intestinal integrity and accelerated tumor growth in the intestine and colon.
Molecular Weight

537.68

Formula

C₂₆H₄₄NNaO₇S

CAS No.

145022-92-0

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (18.60 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8598 mL 9.2992 mL 18.5984 mL
5 mM 0.3720 mL 1.8598 mL 3.7197 mL
10 mM 0.1860 mL 0.9299 mL 1.8598 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: >95.0%

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Keywords:

Tauro-β-muricholic acidT-βMCAFXRNR1H4BileacidcolorectalcancerCRCInhibitorinhibitorinhibit

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Tauro-β-muricholic acid sodium
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