2. Vitamin D Related/Nuclear Receptor
  3. VD/VDR
  4. TEI-9648

TEI-9648, a Vitamin D3 Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9648 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3. TEI-9648 also inhibits HL-60 cell differentiation induced by of 1α,25(OH)2D3. TEI-9648 has the potential for bone metabolism research.

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TEI-9648

TEI-9648 Estructura química

No. CAS : 173388-21-1

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Based on 1 publication(s) in Google Scholar

Other Forms of TEI-9648:

TEI-9648 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE TEI-9648

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Descripciòn

TEI-9648, a Vitamin D3 Lactone analogue, is a potent and specific vitamin D receptor (VDR) antagonist. TEI-9648 inhibits VDR/VDRE-mediated genomic actions of 1α,25(OH)2D3. TEI-9648 also inhibits HL-60 cell differentiation induced by of 1α,25(OH)2D3. TEI-9648 has the potential for bone metabolism research[1][2].

Cellular Effect
Cell Line Type Value Description References
HL-60 IC50
6 nM
Compound: 3
Antagonist activity against 1-alpha,25-dihydroxy vitamin D3-induced HL60 cell differentiation by NBT reduction method
Antagonist activity against 1-alpha,25-dihydroxy vitamin D3-induced HL60 cell differentiation by NBT reduction method
[PMID: 17125259]
In Vitro

TEI-9648 (10-1000 nM) dose-dependently blocks the reciprocal changes of CD11b and CD71 expression associated with HL-60 cell differentiation induced by 1α,25(OH)2D3[1].
TEI-9648 has consistently weaker suppressive effect than TEI-9647[1].
TEI-9648 can not induce cell differentiation even after treatment at 1 μM in HL-60 cell[1].
TEI-9648 alone can not induce activation of NBT-reducing activity or α-NB esterase activity. In contrast, TEI-9648 markedly suppresses the up-regulation induced by 1α,25(OH)2D3 (0.1 nM) in HL-60 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TEI-9648 Related Antibodies
Peso molecular

426.59

Fòrmula

C27H38O4
No. CAS
Appearance

Solid

Color

Off-white to yellow

SMILES

O=C1O[C@H](C[C@H]([C@H]2CC[C@@]3([H])/C(CCC[C@]23C)=C/C=C4C([C@@H](O)C[C@H](O)C\4)=C)C)CC1=C
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvente y solubilidad
In Vitro: 

DMSO : 50 mg/mL (117.21 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3442 mL 11.7209 mL 23.4417 mL
5 mM 0.4688 mL 2.3442 mL 4.6883 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3442 mL 11.7209 mL 23.4417 mL 58.6043 mL
5 mM 0.4688 mL 2.3442 mL 4.6883 mL 11.7209 mL
10 mM 0.2344 mL 1.1721 mL 2.3442 mL 5.8604 mL
15 mM 0.1563 mL 0.7814 mL 1.5628 mL 3.9070 mL
20 mM 0.1172 mL 0.5860 mL 1.1721 mL 2.9302 mL
25 mM 0.0938 mL 0.4688 mL 0.9377 mL 2.3442 mL
30 mM 0.0781 mL 0.3907 mL 0.7814 mL 1.9535 mL
40 mM 0.0586 mL 0.2930 mL 0.5860 mL 1.4651 mL
50 mM 0.0469 mL 0.2344 mL 0.4688 mL 1.1721 mL
60 mM 0.0391 mL 0.1953 mL 0.3907 mL 0.9767 mL
80 mM 0.0293 mL 0.1465 mL 0.2930 mL 0.7326 mL
100 mM 0.0234 mL 0.1172 mL 0.2344 mL 0.5860 mL
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TEI-9648 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TEI-9648173388-21-1TEI9648TEI 9648VD/VDRVitamin DVitamin D receptorVitaminD31α,25-(OH)2D3bonemetabolismCD11bCD71HL-60differentiationInhibitorinhibitorinhibit

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Nombre del producto:
TEI-9648
Cat. No.:
HY-12398A
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